Differences and similarities among circadian characteristics of plasma renin activity in healthy young women in Japan and the United States

Kawasaki, Terukazu; Ueno, Masashi; Uezono, Keiko; Matsuoka, Masao; Omae, Teruo; Halberg, Franz; Wendt, H.; Taggett-Anderson, Mary Ann; Haus, Erhard

doi:10.1016/0002-9343(80)90177-1

Cited by 29 publications

(20 citation statements)

References 12 publications

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“…Mesor values in this study by Kawasaki et al [ 1980] for plasma renin activity (PRA) were lower in Japan than in the USA: they averaged (mean ± SE) 1.64 ± 0.14 as compared to 2.39 ± 0.23 ng/ml/h (p < 0.01). A statistically significant dif ference in dietary salt intake was also indicated by differences in the urinary excretion of sodium and chloride (p < 0.005) by the Japanese and North American women studied.…”

Section: Introductioncontrasting

confidence: 55%

“…groups compared after a rather short span of reduced Na intake show marked differences in average PRA at some time points but not during the span associated with actual Na intake, notably following the second and third meals (which were the only meals providing Na). In an earlier study by Kawasaki et al [1980] two populations living on different Na intake, pre sumably for a very long time, exhibited clearly different mean PRA values at all time points examined. Since ethnicity, climate and, perhaps, habits related to posture also differed, the differences cannot necessarily and exclu sively be attributed only to the effect of Na intake.…”

Section: Resultsmentioning

confidence: 72%

“…The observed increase in circadian mesor is in agreement with results from a recent study on women of different eth nicity, indicating that different habits of salting foods may contribute to geographic (though not necessarily ethnic) differences in circadian char acteristics of the PRA rhythm. It has been demonstrated that users of a saltier diet (Japanese women) exhibit a lower PRA mesor than agematched individuals (Minnesotan women) who eat less salt [Kawasaki et al, 1980]. Several investigations [Halberg, 1974;Halbcrg et al, 1976; have shown that the timing of meals constitutes one of the conditions which modify the circadian system.…”

Section: Discussionmentioning

confidence: 99%

“…This is the more important, since we have recently found correlations between the circan nual amplitude of aldosterone and the risk of developing diseases associated with a high blood pressure [Radke et al, 1980;Halberg et al. 1981], This point will have to be examined by applying the approach here documented along the scales of a year and of a day, to overcome the limitations of this study, which was not controlled as to the stage of rhythms at the time of salt manipulation [Halberget al, 1965;, When the limited original values here presented in table III can be complemented by more extensive sampling along several time scales, timespecific normal values, so-called chronodesms [Halberg et al, 1977 can be computed, in keeping with a start made for PA, PC and PRA under usual conditions elsewhere [Halberg et al" 1981;Kawasaki et al, 1980].…”

Section: Discussionmentioning

confidence: 99%

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Circadian Rhythms of Plasma Renin, Aldosterone and Cortisol on Habitual and Low Dietary Sodium Intake

et al. 1981

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To examine the effects of reducing sodium intake upon the renin-angioten-sin-aldosterone system (RAAS), 5 healthy men and 5 healthy women, 17-37 years old, living under standardized conditions, were sampled around the clock, once on habitual and once on restricted sodium intake. Plasma renin activity (PRA), aldosterone (PA) and cortisol (PC) were determined by radioimmunoassay. All three variables were found to exhibit a statistically significant circadian rhythm, both on habitual and restricted salt intake. After salt restriction, an increase in midline-estimating statistic of rhythm (mesor) of PRA and PA, but not of PC, was observed. The acrophase (an estimate of the time of high values) for PC lagged behind that for PRA and PA. This difference in acrophase was of specially high statistical significance when subjects were on a sodium-restricted diet. These results demonstrate the importance of inferential statistical so-called rhythmometric methods: parameters such as the acrophase can also be used for the assessment of novel effects and for a quantification in time. The derivation of confidence intervals for each rhythm parameter allows one to verify that a given variable exhibits values bracketing an average not only between a higher and a lower, but also between an earlier and a later limit. Changes that may involve only the acrophase, such as a lead or lag, as here noted, are then detected and are of factual as well as methodological interest.

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Section: Introductioncontrasting

confidence: 55%

Section: Resultsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Circadian Rhythms of Plasma Renin, Aldosterone and Cortisol on Habitual and Low Dietary Sodium Intake

et al. 1981

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“…A possible reason for this result is the activation of the renin-angiotensin system at night and early morning. [36][37][38][39][40] To confirm this, it will be necessary to measure the UACR in a future study using fractional urine by a method such as the collection of urine every 2 hours. Regarding our biomarker investigation, we propose that bedtime administration of a telmisartan/amlodipine combination may reduce the risk of AF recurrence in hypertensive patients with paroxysmal AF, and a larger-scale randomized controlled study with the primary endpoint of AF recurrence is thus needed.…”

Section: Discussionmentioning

confidence: 99%

Dose Timing of an Angiotensin II Receptor Blocker/Calcium Channel Blocker Combination in Hypertensive Patients With Paroxysmal Atrial Fibrillation

Kario

Uchiyama²,

Yoshida³

et al. 2016

J of Clinical Hypertension

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It has long been thought that there is a close association between hypertension and atrial fibrillation (AF). However, the efficacy of an angiotensin II receptor blocker for the prevention of organ damage in hypertensive individuals with AF is still controversial. The present study was a multicentered, prospective, randomized, open-label clinical trial investigating the differences in the effect of treatment with telmisartan/amlodipine combination tablets on blood pressure (BP) levels and BP variability between morning and bedtime administration in hypertensive patients with paroxysmal AF, using ambulatory BP monitoring (ABPM) and home BP. With this treatment, the patients' 24-hour BP, nighttime BP, preawake BP, and morning BP shown by ABPM were significantly reduced, and the antihypertensive effects were similar regardless of the timing of the drug administration. The standard deviation of day-by-day home systolic BP and the maximum home systolic BP were also significantly reduced, and these effects were similar regardless of the treatment timing. The N-terminal pro-brain natriuretic peptide level was significantly decreased only in the bedtime administration group. A larger study will demonstrate whether the bedtime administration of telmisartan/amlodipine combination tablets maximizes the risklowering effect against AF recurrence in paroxysmal AF hypertensive patients. J Clin Hypertens (Greenwich). 2016;18:1036-1044. ª 2016 Wiley Periodicals, Inc.A close association between hypertension and atrial fibrillation (AF) has long been suspected. The Framingham Heart Study 1 showed that hypertension was an independent risk factor for incident AF in a general population, and uncontrolled elevated blood pressure (BP) was associated with an increased risk of incident AF in patients treated for hypertension.2 Based on overseas clinical trials, the main etiology of AF is hypertension in approximately 60% of AF patients.3 In addition, the Suita Study, 4 a cohort study in Japan, showed that hypertension was associated with an increased risk of incident AF.It is also suspected that hypertension not only facilitates the onset and persistence of AF, but also raises the risk of a thromboembolism. Antihypertensive treatment is therefore considered essential for hypertensive individuals with AF to prevent recurrent AF, cerebral infarction, or heart failure. 5 In several countries, angiotensin II receptor blockers (ARBs) have attracted attention as a therapeutic drug for hypertensive individuals with AF.6-9 However, the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I) 10 comparing the effect of irbesartan on patients with AF (mainly persistent and permanent types) with that of placebo showed no differences between irbesartan and placebo for the recurrence of AF, indicating that ARBs did not suppress the recurrence of AF. Valsartan also did not reduce the recurrent AF rate in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Atrial Fibrillation (GISSI-AF...

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Role of Sodium and Other Dietary Factors in Hypertension

Langford¹

1984

Nephrology

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Differences and similarities among circadian characteristics of plasma renin activity in healthy young women in Japan and the United States

Cited by 29 publications

References 12 publications

Circadian Rhythms of Plasma Renin, Aldosterone and Cortisol on Habitual and Low Dietary Sodium Intake

Circadian Rhythms of Plasma Renin, Aldosterone and Cortisol on Habitual and Low Dietary Sodium Intake

Dose Timing of an Angiotensin II Receptor Blocker/Calcium Channel Blocker Combination in Hypertensive Patients With Paroxysmal Atrial Fibrillation

Role of Sodium and Other Dietary Factors in Hypertension

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