Difference of LH and FSH secretory characteristics and degree of concordance between postmenopausal and aging women

Genazzani, Alessandro D.; Sgarbi, L.; Montanini, V.; Hartmann, Beda; Surico, N; Biolcati, Andrea; Volpe, Annibale; Genazzani, Andrea R.

doi:10.1016/s0378-5122(96)01088-2

Cited by 19 publications

(9 citation statements)

References 16 publications

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“…In postmenopausal women, an initial increase in LH as well as FSH levels occurs during the early years after menopause. This is, however, followed by a decrease caused by a blunted response to GnRH stimulation as menopause progresses (6,7). Our findings seem not to reflect a change parallel to what is seen in postmenopausal women, however, because the decrease in gonadotropin levels in the men had already begun in the early years after RT.…”

Section: Discussioncontrasting

confidence: 49%

Testosterone Production is Better Preserved After 16 than 20 Gray Irradiation Treatment Against Testicular Carcinoma In Situ Cells

Bang

Petersen

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussioncontrasting

confidence: 49%

Testosterone Production is Better Preserved After 16 than 20 Gray Irradiation Treatment Against Testicular Carcinoma In Situ Cells

Bang

Petersen

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…In conclusion, there appears to be an inverse association between alcoholism and the incidence of ovarian cancer, concentrated among women younger than 60 years. This deficit is compatible with the reduced levels of FSH and LH among alcoholic women younger than 60 years 10, 11. The decrease of ovarian cancer among alcoholic women in Sweden contrasts with the increase of breast cancer in the same cohort of women,21 but these results cannot be explained in terms of competition of outcomes because rates, as contrasted to risks, do not generally compete 13.…”

Section: Discussionmentioning

confidence: 80%

“…Follicle‐stimulating hormone (FSH) and luteinizing hormone (LH) increase substantially during the peri‐menopausal period but tend to decline during old age 10. Alcoholic women, however, have substantially reduced levels of FSH and LH, considerably more striking than the high levels of estrogens that also characterize them 11.…”

mentioning

confidence: 99%

Incidence of ovarian cancer among alcoholic women: A cohort study in Sweden

Λάγιου

Wedrén

et al. 2001

Int. J. Cancer

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Linkage of nationwide databases in Sweden allowed us to evaluate the incidence of ovarian cancer among 36,856 women diagnosed with alcoholism between 1965 and 1994. Mean duration of follow‐up was 9.6 years, for a total of 317,518 person‐years at risk. The expected number of cases of ovarian cancer was calculated by multiplying the number of person‐years by 5‐year age group and calendar year‐specific incidence rates of ovarian cancer in Sweden. The effect measure was the standardized incidence ratio (SIR), with 95% confidence intervals (CIs). Our results indicate an overall deficit of cases of ovarian cancer of about 14% among women with a diagnosis of alcoholism. This deficit is particularly strong and statistically significant among alcoholic women younger than 60 years (SIR = 0.76, 95% CI 0.58–1.00). This deficit is compatible with the reported reduction of gonadotrophin levels among alcoholic women younger than 60 years and with the hypothesis invoking these gonadotrophins in the etiology of ovarian cancer. © 2001 Wiley‐Liss, Inc.

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“…Past studies have shown that aged postmenopausal women (40 years after onset of menopause) have a reduced response of LH and FSH when compared to younger postmenopausal women (~10 years after onset of menopause) following acute injection of GnRH, [42]. Also, aged postmenopausal women (≥15 years after the onset of menopause) have been shown to have significantly lower levels of both gonadotropins when compared to women within 2–5 years after the onset of menopause [43]. This effect of aging could explain the differences observed between VCD-treated follicle-depleted and acyclic aged mice.…”

Section: Discussionmentioning

confidence: 99%

Steroidogenic Capacity of Residual Ovarian Tissue in 4-Vinylcyclohexene Diepoxide-Treated Mice1

Rivera

Christian

Marion

et al. 2009

Biology of Reproduction

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Menopause is an important public health issue because of its association with a number of disorders. Androgens produced by residual ovarian tissue after menopause could impact the development of these disorders. However, it has been unclear whether the post-menopausal ovary retains steroidogenic capacity. Thus, an ovary-intact mouse model for menopause which uses the occupational chemical 4-vinylcyclohexene diepoxide (VCD) was used to characterize the expression of steroidogenic genes in residual ovarian tissue of follicle-depleted mice. Female B6C3F1 mice (28d) were dosed daily for 20d with vehicle or VCD (160 mg/kg/day) to induce ovarian failure. Ovaries were collected on d181 and analyzed for mRNA and protein. Acyclic aged mice were used as controls for natural ovarian senescence. Relative to cycling controls, expression of mRNA encoding steroidogenic acute regulatory protein (Star), cholesterol side chain cleavage (Cyp11a1), 3β-hydroxysteroid dehydrogenase (Hsd3b), 17α-hydroxylase (Cyp17a1), scavenger receptor class B, type 1 (Scarb1), low density lipoprotein receptor (Ldlr) and luteinizing hormone receptor (Lhcgr) was enriched in VCD-treated ovaries. In acyclic aged ovaries mRNA for only Cyp17a1 and Lhcgr was greater than controls. Compared to cycling controls, ovaries from VCD-treated and aged mice had similar levels of HSD3B, CYP17A1 and LHCGR protein. The pattern of protein immunofluorescence staining for HSD3B in follicle-depleted (VCD-treated) ovaries was homogeneous while that for CYP17A1 was only seen in residual interstitial cells. Circulating levels of FSH and LH were increased, and androstenedione levels were detectable following follicle depletion in VCD-treated mice. These findings support that residual ovarian tissue in VCD-treated mice retains androgenic capacity.

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Difference of LH and FSH secretory characteristics and degree of concordance between postmenopausal and aging women

Cited by 19 publications

References 16 publications

Testosterone Production is Better Preserved After 16 than 20 Gray Irradiation Treatment Against Testicular Carcinoma In Situ Cells

Testosterone Production is Better Preserved After 16 than 20 Gray Irradiation Treatment Against Testicular Carcinoma In Situ Cells

Incidence of ovarian cancer among alcoholic women: A cohort study in Sweden

Steroidogenic Capacity of Residual Ovarian Tissue in 4-Vinylcyclohexene Diepoxide-Treated Mice1

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