Difference of cancer core distribution between first and repeat biopsy: In patients diagnosed by extensive transperineal ultrasound guided template prostate biopsy

Furuno, T.; Demura, Takayoshi; Kaneta, Tatsuo; Gotoda, Hiroko; Muraoka, Shunji; Sato, Toshihiro; Nagamori, Satoshi; Shinohara, Nobuo; Koyanagi, Tomohiko

doi:10.1002/pros.10298

Cited by 62 publications

(45 citation statements)

References 20 publications

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“…Furuno et al 4 report using transperineal template-guided approach in the initial biopsy setting and achieved a 49% cancer detection rate using an average of only 18 cores. In this same study, the group reported a 26% yield in the repeat biopsy setting, with an average of 19 cores sampled.…”

Section: Discussionmentioning

confidence: 99%

“…TTMB was originally used at our institution only for men who had undergone at least one prior negative biopsy, but had persistently elevated prostate specific antigen (PSA) and/or a diagnosis of atypical small acinar proliferation or multifocal high-grade prostatic intraepithelial neoplasia on prior biopsy. Eventually, as other institutions began publishing on use of the transperineal approach for initial biopsy, 4,5 we began to offer TTMB to men as initial biopsy procedure for an elevated PSA. This study reports on 294 men who underwent TTMB as repeat biopsy and 79 men who had TTMB performed as initial biopsy.…”

Section: Methodsmentioning

confidence: 99%

“…For each biopsy core, the template coordinate and the offset from base were recorded. Biopsy regions included posterior prostate (3,4,12,13,21,22), posterior lateral (2,5,11,14,20,23), anterior lateral (1,6,9,10,15,16), anterior apex (19,24), and TZ (7,8,17,18) After completion of all sampling, patients underwent cystoscopic evaluation.…”

Section: Methodsmentioning

confidence: 99%

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Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

260

171

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Transrectal ultrasound (TRUS) biopsy can miss 20-30% of clinically significant cancers. We evaluate an alternative approach-transperineal template-guided mapping biopsy (TTMB) in the initial and repeat biopsy setting. From January 2005 through September 2008, 373 consecutive men underwent TTMB (294 men with X1 prior negative biopsy and 79 men as the initial biopsy). The location of each positive biopsy core, number of positive cores, and percent involvement of each core was recorded. Cancer detection rate for the initial biopsy was 75.9%. For men with 1, 2, and X3 prior negative biopsies detection rates were 55.5%, 41.7%, and 34.4%, respectively. In all, 55.5% of the cancers identified were Gleason X7. The majority of the cancers were multifocal. There was no significant change in the number of positive cores or Gleason score as the number of prior biopsies increased. The anterior and apical aspects of the prostate were among the most common cancer locations. TTMB provides a high rate of cancer detection as initial and repeat biopsy. TTMB was particularly effective at diagnosing anterior and apical cancer. TTMB may have particular application for men considering active surveillance, with prior negative TRUS biopsies, and those considering subtotal gland or other minimally invasive treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

260

171

View full text Add to dashboard Cite

show abstract

“…We have adapted the template grid technique for prostate biopsy to detect early-stage prostate carcinoma in men who have not undergone a previous biopsy, as well as those who had previous negative biopsies and remained at high risk for prostate carcinoma. 8 In the current study, we analyzed the distribution of carcinoma cores in the prostate with systematic ultrasound-guided transperineal template biopsy to demonstrate whether prostate carcinoma is distributed equally throughout the entire prostate.…”

mentioning

confidence: 99%

Differences in tumor core distribution between palpable and nonpalpable prostate tumors in patients diagnosed using extensive transperineal ultrasound‐guided template prostate biopsy

Demura

Hioka

Furuno

et al. 2005

Cancer

Self Cite

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BACKGROUNDThe authors performed extensive transperineal ultrasound‐guided template prostate biopsies to investigate carcinoma core distribution.METHODSBetween August 2000 and May 2004, 371 men underwent template biopsies. Three hundred twelve patients had not undergone a previous biopsy (first group) and 59 had undergone previous transrectal sextant biopsies (repeat group). Of the 312 patients in the first group, 236 had normal digital rectal examination (DRE) findings (DRE– first group) and 76 patients had an abnormal DRE (DRE+ first group). A mean of 20.1 biopsy cores (range, 9–38 cores) was taken from the entire prostate. The region > 2.0 cm from the rectal face of the prostate was defined as the anterior region and the remaining area was defined as the posterior region.RESULTSIn the DRE– first group, the carcinoma core rate (number of tumor cores/number of biopsy cores) in the anterior region (7.2%) did not differ from that of the posterior region (7.3%) (P = 0.9635). However, in the DRE+ first group, the carcinoma core rate in the posterior region (22.0%) was found to be higher than in the anterior region (13.2%) (P < 0.0001). In the repeat group, the carcinoma core rate in the posterior region (3.1%) was significantly (P = 0.0008) lower than that exhibited in the anterior region (7.2%).CONCLUSIONSThe results of the current study suggest that nonpalpable prostate carcinoma is distributed equally within the entire prostate, although palpable carcinoma is distributed mainly in the posterior region and many of the tumor foci in the anterior region may be missed by a transrectal sextant biopsy. The examination of radical prostatectomy specimens is required to prove these results. Cancer 2005. © 2005 American Cancer Society.

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“…Furuno et al demonstrated that on repeat biopsy in high risk patients, the anterior region of the prostate harbors cancers which cannot be detected with standard biopsy techniques. 5 Increasing the number of cores for larger prostates allows us to find prostate cancer foci that may be missed with standard techniques. Remzi et al developed a nomogram that incorporates prostate size and patient age to maximize the detection of prostate carcinoma in the prostate specific antigen (PSA) range of 2 to 10 ng/ml.…”

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confidence: 99%

Optimizing Prostate Biopsy Techniques

Kibel

2007

Journal of Urology

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Difference of cancer core distribution between first and repeat biopsy: In patients diagnosed by extensive transperineal ultrasound guided template prostate biopsy

Abstract: These results suggest that transrectal sextant biopsies miss more cancers in the anterior region than in the posterior. We believe template technique has an advantage to be able to detect cancer equally in the anterior and posterior.

Cited by 62 publications

References 20 publications

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Differences in tumor core distribution between palpable and nonpalpable prostate tumors in patients diagnosed using extensive transperineal ultrasound‐guided template prostate biopsy

Optimizing Prostate Biopsy Techniques

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