2000
DOI: 10.1016/s0090-6980(00)00091-5
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Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients

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Cited by 18 publications
(10 citation statements)
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“…The relationship between urinary LTE 4 and 11DTXB 2 in the pathogenesis of asthma has been reported by several investigators; [2][3][4][5]8,11,13,20 because of the instability of CysLTs and TXA 2 , the end-products of the cascade were determined. However, most studies have been Fig.…”
Section: Discussionmentioning
confidence: 80%
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“…The relationship between urinary LTE 4 and 11DTXB 2 in the pathogenesis of asthma has been reported by several investigators; [2][3][4][5]8,11,13,20 because of the instability of CysLTs and TXA 2 , the end-products of the cascade were determined. However, most studies have been Fig.…”
Section: Discussionmentioning
confidence: 80%
“…Suzuki et al 2 reported that no significant relationship was observed between urinary LTE 4 and 11DTXB 2 in asthmatic patients. Oosaki et al 3 also examined the relationship in changes (%) between these two metabolites; however, they noted no significant difference.…”
Section: Discussionmentioning
confidence: 96%
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“…Leukotrienes are produced by mast cells, eosinophils, and other airway inflammatory cells and increase vascular permeability, constrict bronchial smooth muscle, and mediate bronchial hyperresponsiveness. 5 Levels of urinary LTE 4 , the stable metabolite of LTC 4 and LTD 4 , 6 7 are increased in children 8 and adults 9 with asthma compared with healthy controls and in asthmatics after bronchial challenge with antigen, 10 11 after oral challenge with aspirin in aspirin sensitive asthmatic subjects, 12 and during exercise induced bronchospasm. 13 The importance of leukotrienes in the pathology of asthma has been further demonstrated in large clinical trials with agents that block the actions of leukotrienes.…”
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confidence: 99%