Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients

Urinary leukotriene E4 and 11-dehydro-thromboxane B2 excretion in children with bronchial asthma

“…The relationship between urinary LTE 4 and 11DTXB 2 in the pathogenesis of asthma has been reported by several investigators; [2][3][4][5]8,11,13,20 because of the instability of CysLTs and TXA 2 , the end-products of the cascade were determined. However, most studies have been Fig.…”

“…Suzuki et al 2 reported that no significant relationship was observed between urinary LTE 4 and 11DTXB 2 in asthmatic patients. Oosaki et al 3 also examined the relationship in changes (%) between these two metabolites; however, they noted no significant difference.…”

“…3 In the present study, urinary levels of LTE 4 and 11DTXB 2 were slightly higher than those reported previously. [2][3][4][5]8,11,13,20 Osamura et al had reported that urinary levels of 11DTXB 2 were significantly high between 1 and 3 years after birth and that they tended to decrease gradually with age thereafter. 21 Because all our subjects were children (1-15 years of age), this may explain why the urinary levels of 11DTXB 2 were slightly higher in the present study than those reported previously.…”

“…Moreover, increased production of CysLTs in asthmatic patients in vivo has been observed in several studies. [1][2][3][4][5]11,12 A potent bronchoconstrictor, TXA 2 is generated from arachidonic acid by cyclooxygenase. Enhanced TXA 2 release has also been reported in asthmatic patients after allergen challenge.…”

Oral gefitinib produces symptomatic and radiological benefit in advanced NSCLC

“…Leukotrienes are produced by mast cells, eosinophils, and other airway inflammatory cells and increase vascular permeability, constrict bronchial smooth muscle, and mediate bronchial hyperresponsiveness. 5 Levels of urinary LTE 4 , the stable metabolite of LTC 4 and LTD 4 , 6 7 are increased in children 8 and adults 9 with asthma compared with healthy controls and in asthmatics after bronchial challenge with antigen, 10 11 after oral challenge with aspirin in aspirin sensitive asthmatic subjects, 12 and during exercise induced bronchospasm. 13 The importance of leukotrienes in the pathology of asthma has been further demonstrated in large clinical trials with agents that block the actions of leukotrienes.…”