Difference in the response to isoproterenol between asymmetric septal hypertrophy and symmetric hypertrophy in patients with hypertrophic cardiomyopathy

Iida, Keiji; Sugishita, Yasuro; Matsuda, Mitsuo; Yamaguchi, Tetsu; Ajisaka, Ryuichi; Matsumoto, Ryuma; Fujita, Tsuneo; Yukisada, Kimihiko; Ito, Iwao

doi:10.1002/clc.4960090103

Cited by 17 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…None of the patients with a significant gradient (>50 mm Hg) had a LVETI value <423 ms, and only 1 of the patients without a significant gradient had a LVETI >423 ms. The parallel increase of pressure gradient and LVETI in the patients in whom isoproterenol was infused sug gested that LVET is a reliable index which can identify patients with a gradient at rest and during pharmacolog ical intervention [28,35,36], A comparison of the current study with previous observations reveals considerable discrepancies. Stefadouros et al [37] found a correlation between pressure gradient and LVET in patients with hypertrophic cardio myopathy, but they found a better correlation with the PEP/LVET ratio.…”

Section: Control Groupcontrasting

confidence: 50%

Hypertrophic Cardiomyopathy: Noninvasive Identification of Patients with Significant Pressure Gradient

Boudoulas¹,

Mantzouratos²,

Geleris³

et al. 1987

Am J Noninvas Cardiol

View full text Add to dashboard Cite

In 49 patients with hypertrophic cardiomyopathy, systolic time interval measurements, echocardiograms, and catheterization were performed within 48 h. Eighteen patients were without left ventricular outflow tract pressure gradient (LV-PG), 16 had mild to moderate LV-PG (l-< 50 mm Hg), and 15 had significant LV-PG (> 50 mm Hg). A high degree of correlation was found between heart rate corrected left ventricular ejection time (LVETI) and LV-PG (r = 0.87). LVETI in patients with hypertrophic cardiomyopathy, but no LV-PG, was shorter than normal (389 ± 17 vs. 413 ± 13 ms; p < 0.01). All patients with significant LV-PG (> 50 mm Hg) had LVETI > 423 ms, and only 1 patient without significant LV-PG had LVETI >423 ms (100% sensitivity, 97% specificity). In 4 patients in whom LVETI and LV-PG were measured before and during isoproterenol infusion, changes in both parameters were parallel. No other échocardiographie (including systolic anterior motion of mitral valve) or systolic time interval measurements reliably identified patients with significant LV-PG. Thus, in patients with hypertrophic cardiomyopathy (1) LVETI is shorter than normal in the absence of LV-PG, and (2) the measurement of LVETI reliably identifies patients with significant LV-PG at rest and during adrenergic stimulation.

show abstract

Section: Control Groupcontrasting

confidence: 50%

Hypertrophic Cardiomyopathy: Noninvasive Identification of Patients with Significant Pressure Gradient

Boudoulas¹,

Mantzouratos²,

Geleris³

et al. 1987

Am J Noninvas Cardiol

View full text Add to dashboard Cite

show abstract

“…FS and pVs were larger in patients with HCM than in NC at rest and during exercise in the present study. Several studies reported hypercontractile condition of HCM (Bonow er af., 1981;Braunwald et al, 1964;Iida et al, 1986;Williams et al, 1973). In view of systolic performance, exercise capacity and cardiac reserve to exercise can be thought to be excellent in patients with HCM, as shown in our previous paper (Sugishita er al., 1983).…”

Section: Discussionmentioning

confidence: 99%

“…The technique has been described previously (Iida et al, 1983(Iida et al, , 1986Matsuda et al, 1983). From the digitized data, the following values were calculated and printed out: (1) the left ventricular enddiastolic dimension (EDD) which was determined at the time of the R wave of the electmcardiogram and the end-systolic dimension (ESD) which was determined at the time of onset of the second heart sound on the phonocardiogram.…”

Section: Digitized Echocardiographic Analysismentioning

confidence: 99%

Impaired left ventricular rapid filling during exercise in patients with hypertrophic cardiomyopathy

Iida

Yukisada

Sugishita

et al. 1987

Clinical Cardiology

Self Cite

View full text Add to dashboard Cite

Summary: The influence of exercise on left ventricular diastolic filling was evaluated in 14 patients with hypertrophic cardiomyopathy (HCM) and 14 normal controls (NC) by dynamic exercise echocardiography . Using X-Y digitizer and computer, normalized peak rate of change of the left ventricular dimension during systole (pVs) and the rapid filling phase (pVd) were determined from the left ventricular echocardiograms at rest and during exercise when heart rate reached 100 beatshin.At rest and during exercise, pVs was significantly higher in HCM (3.2*0.4/s at rest, 4.3*1.4/s during exercise) than in NC (2.4f0.5h at rest, 3 . 0 f 0 . 4~ during exercise) (p

show abstract

“…ISP Echocardiography The ISP test was performed in the afternoon in all 22 patients using a previously described technique. [11][12][13][14][15] Briefly, the patient lay in the supine position in a darkened room, and ISP was infused for 5 min through an antecubital vein at doses of 0.01 and 0.02 g•kg -1 •min -1 using a calibrated infusion pump. During ISP infusion, the electrocardiogram was monitored continuously.…”

Section: Echocardiographic Studiesmentioning

confidence: 99%

Using Isoproterenol Stress Echocardiography to Predict the Response to Carvedilol in Patients With Dilated Cardiomyopathy

et al. 2001

View full text Add to dashboard Cite

Trials have demonstrated that carvedilol can produce hemodynamic, symptomatic, and prognostic improvements in dilated cardiomyopathy (DCM), but some DCM patients have deteriorated after carvedilol, developing congestive heart failure. The present study investigated the use of isoproterenol (ISP) stress echocardiography to select those patients with DCM who would respond to carvedilol. ISP was infused intravenously in 22 patients with DCM and they were classified into 2 groups based on the left ventricular systolic response: good response to ISP [change in fractional shortening (FS) with ISP > 0.05, n=13] and poor response to ISP (change < or = 0.05, n=9). In the good response group, FS significantly increased from 0.12+/-0.04 to 0.17+/-0.08 (mean+/-SD, p<0.05) with carvedilol, and 7 patients improved symptomatically (New York Heart Association class). However, in the poor response group, no significant difference was observed between FS at baseline and that at the end of follow-up. Moreover, only 1 patient in the poor response group improved symptomatically. ISP stress echocardiography can assist in selecting patients with DCM who will respond positively to carvedilol.

show abstract

Difference in the response to isoproterenol between asymmetric septal hypertrophy and symmetric hypertrophy in patients with hypertrophic cardiomyopathy

Cited by 17 publications

References 23 publications

Hypertrophic Cardiomyopathy: Noninvasive Identification of Patients with Significant Pressure Gradient

Hypertrophic Cardiomyopathy: Noninvasive Identification of Patients with Significant Pressure Gradient

Impaired left ventricular rapid filling during exercise in patients with hypertrophic cardiomyopathy

Using Isoproterenol Stress Echocardiography to Predict the Response to Carvedilol in Patients With Dilated Cardiomyopathy

Contact Info

Product

Resources

About