Difference in the Actions of Nicotine and Tyramine on Isolated Atria

Biological Activity of Diazonium Compounds (Ii): Positive Ino- And Chronotropic Actions on Guinea Pig Atria of 4 (Or 5)-Diazo-Imidazole-5 (Or 4)-Carboxamide

“…The thorax was opened and the heart was rapidly removed. Atria were freed of ventricular muscle, fat and connective tissue and were suspended in Tyrode solution aerated with a mixture of 95% 02 and 5% CO, at 30°C (19). The amplitude and rate of spontaneous atrial contraction were recorded on a smoked drum via a tension balance.…”