Difference in non‐weight‐bearing effects on bone mineral density between trunk and peripheral fat mass in women with polycystic ovary syndrome

Yanazume, Yumi; Kawamura, Yukie; Kuwahata, A.; Yonehara, Yukie; Matsuo, Takashi; Iwamoto, Ichiro; Douchi, Tsutomu

doi:10.1111/j.1447-0756.2009.01133.x

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Women with menstrual dysfunction related to polycystic ovarian syndrome seem to have increased areal BMD and possibly also higher bone material quality (63). Moreover, differences in regional body composition (increased central adiposity and truncal mass) may contribute to site-specific BMD increases in participants with polycystic ovarian syndrome (64). The heavier population in the study by Waller et al (30) and screening criteria may account for the decreased ability of this study to show differences in bone change by the presence or absence of ovulatory disturbances.…”

Section: Discussionmentioning

confidence: 99%

Negative Spinal Bone Mineral Density Changes and Subclinical Ovulatory Disturbances—Prospective Data in Healthy Premenopausal Women With Regular Menstrual Cycles

Li¹,

Hitchcock²,

Barr³

et al. 2013

Epidemiologic Reviews

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Subclinical ovulatory disturbances (anovulation or short luteal phases within normal-length menstrual cycles) indicate lower progesterone-to-estrogen levels. Given that progesterone plays a bone formation role, subclinical ovulatory disturbances may be associated with bone loss or less than expected bone gain. Our purpose was to perform a meta-analysis of prospective studies in healthy premenopausal women to determine the overall relationship of subclinical ovulatory disturbances to change in bone mineral density. Two reviewers independently identified from serial literature searches 6 studies meeting inclusion criteria: a 2-year study in 114 young adult women, 2006-2009, Vancouver, Canada; a 2-year study in 189 premenopausal women, 2000-2005, Toronto, Canada; a single-cycle study in 14 young women, 1996-1997, Melbourne, Australia; an 18-month study in 53 women, 1990-1995, Santa Clara, California; a 4-year study in 27 women, 1988-1995, Vancouver, Canada; and a 1-year study in 66 women, 1985-1988, Vancouver, Canada. This meta-analysis included a combined sample size of 473 observations in 436 premenopausal women studied over 1-4 years and aged 14-47 years. The percentage of women with ovulatory disturbances varied significantly from 13% to 82%. Women with more frequent ovulatory disturbances had more negative percentage changes in spine bone mineral density (weighted mean difference = -0.86; P = 0.040) for random-effects analysis. There was significant heterogeneity among these 6 studies (I(2) = 80%). In summary, these data show that regularly menstruating women with more frequent ovulatory disturbances experience more negative changes in bone (approximately -0.9% per year). These cycles with silent estrogen/progesterone imbalance may be clinically important.

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Section: Discussionmentioning

confidence: 99%

Negative Spinal Bone Mineral Density Changes and Subclinical Ovulatory Disturbances—Prospective Data in Healthy Premenopausal Women With Regular Menstrual Cycles

Li¹,

Hitchcock²,

Barr³

et al. 2013

Epidemiologic Reviews

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show abstract

“…In men, testosterone treatment increased lean body mass [44] and BMD [45]. In PCOS, testosterone levels correlated significantly with muscle mass [46,47], and regional muscle mass correlated significantly with respective regional BMD [46,47]. Taken together, data suggest that increased central fat, increased lean body mass and hyperinsulinemia may be predictors of high BMD in PCOS.…”

Section: Body Composition Insulin Resistance and Bmdmentioning

confidence: 64%

Bone mineral density and vitamin D in PCOS and hirsutism

Glintborg

Hermann

Andersen

2013

Expert Review of Endocrinology & Metabolism

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Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in reproductive-aged women. The majority of hirsute patients are diagnosed with PCOS. Hyperandrogenemia, central obesity and insulin resistance may protect patients with PCOS from osteoporosis, whereas increased cortisol levels, low growth hormone and amenorrhea may be associated with decreased bone mineral density (BMD). Recent studies suggested that insulin resistance in PCOS is associated with decreased vitamin D levels that could not be explained by obesity alone. Vitamin D treatment may therefore have positive effects on insulin sensitivity and perhaps also hyperandrogenemia in patients with PCOS. In the present article, we review the evidence of changed BMD, bone mineral turnover and vitamin D status in PCOS and hirsutism compared with healthy women and the effects of medical intervention on BMD in PCOS.

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Effects of distinct Polycystic Ovary Syndrome phenotypes on bone health

et al. 2023

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Polycystic Ovary Syndrome (PCOS) is a highly prevalent and heterogenous endocrinopathy affecting 5-18% of women. Although its cardinal features include androgen excess, ovulatory dysfunction, and/or polycystic ovarian morphology, women often display related metabolic manifestations, including hyperinsulinaemia, insulin resistance, and obesity. Emerging data reveal that the hormonal alterations associated with PCOS also impact bone metabolism. However, inconsistent evidence exists as to whether PCOS is a bone-protective or bone-hindering disorder with an accumulating body of clinical data indicating that hyperandrogenism, hyperinsulinaemia, insulin resistance, and obesity may have a relative protective influence on bone, whereas chronic low-grade inflammation and vitamin D deficiency may adversely affect bone health. Herein, we provide a comprehensive assessment of the endocrine and metabolic manifestations associated with PCOS and their relative effects on bone metabolism. We focus principally on clinical studies in women investigating their contribution to the alterations in bone turnover markers, bone mineral density, and ultimately fracture risk in PCOS. A thorough understanding in this regard will indicate whether women with PCOS require enhanced surveillance of bone health in routine clinical practice.

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Difference in non‐weight‐bearing effects on bone mineral density between trunk and peripheral fat mass in women with polycystic ovary syndrome

Abstract: Trunk fat mass, despite the smaller amount, is more associated with arm BMD than peripheral fat mass is through its non-weight-bearing effects.

Cited by 3 publications

References 27 publications

Negative Spinal Bone Mineral Density Changes and Subclinical Ovulatory Disturbances—Prospective Data in Healthy Premenopausal Women With Regular Menstrual Cycles

Negative Spinal Bone Mineral Density Changes and Subclinical Ovulatory Disturbances—Prospective Data in Healthy Premenopausal Women With Regular Menstrual Cycles

Bone mineral density and vitamin D in PCOS and hirsutism

Effects of distinct Polycystic Ovary Syndrome phenotypes on bone health

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