Difference in nitroglycerin dose-response in the venous and arterial beds

Imhof, P; Ott, B.; Frankhauser, Pascal; Chu, L.‐C.; Hodler, J

doi:10.1007/bf00874655

Cited by 156 publications

(67 citation statements)

References 10 publications

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“…We and other groups have previously shown arterial waveform analysis represents a particularly sensitive method to detect and monitor the hemodynamic action of organic nitrates in altering the geometry and distensibility of peripheral blood vessels. 4,20,21,31,32 The residual hemodynamic effect detected by this methodology could not be identified by monitoring changes in heart rate or blood pressure in response to nitrate administration. The discrepancy between our findings and those of Bassenge et al 4 may relate to differences in data acquisition and descriptive analysis of the morphological change in the pulse contour accompanying nitrate administration.…”

Section: Discussionmentioning

confidence: 99%

“…Blood pressure waveforms were digitized at 200 samples/second, and those with a correlation coefficient of Ͻ0.95 were discarded. A printout of an average waveform representative of the 30-second data set was analyzed quantitatively using a modification of the method described by Imhof et al 21 An A/B ratio was calculated by measuring peak and trough heights on the average waveform generated from the pulse waveform analysis. A was measured as the height of the systolic peak and B as the height of the trough preceding the dicrotic notch.…”

Section: Hemodynamic Measurementsmentioning

confidence: 99%

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Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance

et al. 2002

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Background-The therapeutic benefits that accompany the continuous administration of organic nitrates are attenuated by the development of tolerance to the compounds. Altered superoxide production and NO bioavailability have been implicated in contributing to the development of tolerance, an effect that may be ameliorated by the administration of antioxidants. Methods and Results-We studied the effect of 3 days of continuous transdermal administration of nitroglycerin (NTG) (10 mg/24 hours) on platelet free radical (NO and superoxide anion [O 2 ·Ϫ ] activity) with and without coadministration of supplemental ascorbate (2.4 g/24 hours). NAD(P)H oxidase activity, nitric oxide synthase (NOS) activity, and cyclic guanosine monophosphate (cGMP) content were also assessed. Radial artery pressure pulse waveforms were used to track the hemodynamic actions of NTG. Three days of NTG/placebo was associated with a significant increase in platelet NO and O 2 ·Ϫ production from 1.0Ϯ1.17 to 2.52Ϯ0.88 pmol/10 8 platelets and 13.2Ϯ4.8 to 72.5Ϯ34.4 pmol/10

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Section: Discussionmentioning

confidence: 99%

Section: Hemodynamic Measurementsmentioning

confidence: 99%

Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance

et al. 2002

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“…Introduction Nitroglycerin (NTG) causes both venous and arterial peripheral vasodilatation resulting in reductions in preload and afterload (Imhof et al, 1980). Continuous exposure to NTG leads to an attenuation of its haemodynamic effects, i.e.…”

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confidence: 99%

Parallel tolerance between platelet cyclic GMP and preload effects of nitroglycerin in anaesthetized mini‐pigs

Baines

Szwarc

Ball

1994

British J Pharmacology

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The effects of acute intravenous nitroglycerin (NTG) administration on platelet cyclic GMP in relation to changes in indices of preload (end-diastolic volume) and afterload (effective arterial elastance) were evaluated in the anaesthetized mini-pig, using pressure-volume analysis. NTG (1 -30 [ig kg-' min-', i.v.) elicited a dose-dependent fall in preload and afterload, and an increase in arterial blood platelet cyclic GMP. Repeated doses of NTG (30 pg kg-' min ') resulted in tolerance to the preload but not afterload effects. The increases in platelet cyclic GMP were also attenuated, being highly correlated with the preload changes. Therefore, platelet cyclic GMP appears to reflect NTG-induced venous tolerance, rather than arterial responsiveness. The measurement of platelet cyclic GMP may represent a simple approach for monitoring the degree of venous tolerance to NTG in animals or patients, facilitating further mechanistic investigations.

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“…Maximum plasma concentrations are reached within a few minutes after sublingual administration (7,16,22,50,63,102). The nitroglycerin concentrations in plasma rapidly decrease again, however.…”

Section: Sublingual Absorptionmentioning

confidence: 95%

“…Data in the literature differ widely (19). For example, in one study the plasma concentration of nitroglycerin after sublingual administration of 0.3 mg nitroglycerin was about 1 ng/ml (16), while in another it was less than 1 ng/ml after administration of 1.6 mg nitroglycerin (50). The bioavailability of nitroglycerin after sublingual administration is on average 36 % (79).…”

Section: Sublingual Absorptionmentioning

confidence: 99%

Nitroglycerin [BAT Value Documentation, 1998]

Bolt¹

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Biological Exposure Values for Occupational Toxicants and Carcinogens , Vol. 3 (1998) The article contains sections titled: Pharmacokinetics and Pharmacodynamics Kinetics Metabolism Dose‐dependency of the Effects of Nitroglycerin Pharmacodynamics Interaction Critical Toxicity Exposure and Effects Relationship between External and Internal Exposure Relationship between Internal Exposure and Effect Selection of the Indicators Nitroglycerin in Blood Glycerol‐1,2‐dinitrate and Glycerol‐1,3‐dinitrate in Blood Methodology Background Exposure Evaluation of the BAT Value Interpretation of the Data

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Difference in nitroglycerin dose-response in the venous and arterial beds

Cited by 156 publications

References 10 publications

Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance

Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance

Parallel tolerance between platelet cyclic GMP and preload effects of nitroglycerin in anaesthetized mini‐pigs

Nitroglycerin [BAT Value Documentation, 1998]

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