Difference in Mortality and Morbidity Between Extremely and Very Low Birth Weight Neonates

Lianou, Loukia; Petropoulou, Chrysa; Lipsou, Niki; Bouza, Helen

doi:10.1891/nn-2021-0015

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Важно заметить, что только для организаций 3 уровня масса тела при рождении менее 750 грамм оказалась статистически значимым предиктором потребности коррекции проводимой терапии (ОШ=3,1 95 %ДИ [1,[3][4][5][6][7]5], р = 0,013). Пациенты с экстремально низкой массой тела имеют максимальную в сравнении с другими новорожденными заболеваемость и смертность [17,18]. В организациях первого уровня, независимо от массы тела и гестационного возраста новорожденного, наблюдается максимальная потребность в коррекции проводимой интенсивной терапии, то есть в повышении уровня помощи.…”

Section: Discussionunclassified

Predicting the need for pre-transport adjustments in neonatal intensive care depending on the level of initial medical organization

Mukhametshin,

Kovtun,

Davydova

et al. 2023

Урал. мед. журнал

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Introduction. The need for intensive care adjustments to be made by the transport team at the originating medical organization remains an important element of pre-transport preparation, being an indirect indicator that the level of care does not match the needs of the patient. The aim of the study is to identify factors associated with the need for therapy adjustments depending on the level of initial medical organization. Materials and methods. The one-stage, cross-sectional study included the data of visits of the neonatal transport team of the resuscitation and consultative centre of the Regional Children’s Clinical Hospital (Ekaterinburg) in the period 01. 07. 2014–31. 12. 2018 (n = 2029). The sample was divided into groups: the first group – patients from level 1 organizations (22.8 %, n = 462), the second group – patients from level 2 organizations without paediatric intensive care units (34.9 %, n = 709), the third group – patients from level 2 organizations with paediatric intensive care units (32.5 %, n = 659), the fourth group – patients from level 3 institutions (9.8 %, n = 199). Results. The need for therapy adjustment at baseline was dependent on the level of the institution, with a maximum in level 1 organizations and a minimum in level 3 organizations. The odds ratio of need for therapy correction for level 1 organizations compared to level 2 organizations with paediatric intensive care units was 1.4, 95 % CI [1.2–1.7], p = 0.002, and compared to level 3 organizations was 1.6, 95 % CI [1.2–2.3], p = 0.003. Multivariate analysis identified the following factors associated with the need to adjust therapy at the original facility: for level 1 facilities, respiratory support, dopamine administration; for level 2 facilities without paediatric intensive care units, respiratory support, dopamine and epinephrine infusion, sedation; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; and for level 3 facilities with paediatric intensive care units, respiratory support, dopamine infusion. Discussion. The need for respiratory support and administration of catecholamines are indicators of the severity of the patient’s condition. Patients in low-acuity healthcare organizations require an increased level of care, regardless of the birth weight and gestational age of the newborn. Conclusion. Logistic regression analysis revealed factors associated with the need for therapy correction in patients in the initial medical organizations depending on their level. The following factors played a statistically significant role: respiratory support, sedation, intravenous infusion of catecholamines, patient weight.

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Section: Discussionunclassified

Predicting the need for pre-transport adjustments in neonatal intensive care depending on the level of initial medical organization

Mukhametshin,

Kovtun,

Davydova

et al. 2023

Урал. мед. журнал

View full text Add to dashboard Cite

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Gastrointestinal perforation in extremely low birth weight infants: A single center retrospective study in China

Feng,

Zhang,

Yan

et al. 2024

Pediatrics & Neonatology

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Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants

Perrone

Manti

Buttarelli

et al. 2023

IJMS

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Bronchopulmonary dysplasia (BPD) still represents an important burden of neonatal care. The definition of the disease is currently undergoing several revisions, and, to date, BPD is actually defined by its treatment rather than diagnostic or clinic criteria. BPD is associated with many prenatal and postnatal risk factors, such as maternal smoking, chorioamnionitis, intrauterine growth restriction (IUGR), patent ductus arteriosus (PDA), parenteral nutrition, sepsis, and mechanical ventilation. Various experimental models have shown how these factors cause distorted alveolar and vascular growth, as well as alterations in the composition and differentiation of the mesenchymal cells of a newborn’s lungs, demonstrating a multifactorial pathogenesis of the disease. In addition, inflammation and oxidative stress are the common denominators of the mechanisms that contribute to BPD development. Vascular endothelial growth factor-A (VEGFA) constitutes the most prominent and best studied candidate for vascular development. Animal models have confirmed the important regulatory roles of epithelial-expressed VEGF in lung development and function. This educational review aims to discuss the inflammatory pathways in BPD onset for preterm newborns, focusing on the role of VEGFA and providing a summary of current and emerging evidence.

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Difference in Mortality and Morbidity Between Extremely and Very Low Birth Weight Neonates

Cited by 4 publications

References 16 publications

Predicting the need for pre-transport adjustments in neonatal intensive care depending on the level of initial medical organization

Predicting the need for pre-transport adjustments in neonatal intensive care depending on the level of initial medical organization

Gastrointestinal perforation in extremely low birth weight infants: A single center retrospective study in China

Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants

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