Difference in Morning and Evening Choroidal Thickness in Japanese Subjects With No Chorioretinal Disease

Toyokawa, Noriko; Kimura, Hideya; Fukomoto, Atsuko; Kuroda, Shinichiro

doi:10.3928/15428877-20120102-06

Cited by 29 publications

(22 citation statements)

References 21 publications

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“…Tan et al [19] reported a mean CT of 372.2 μ m measured by SD-OCT in a younger age group, but the RE was similar. Toyokawa et al [22] reported a mean CT of 308.5 μ m, similar to our study, but the mean age was older (62.6 years). In the study by Ikuno et al [14], the mean choroidal thickness was 354 μ m by 1060 nm HP-OCT, the patients had a wider range of age (23–88 years old), and the mean RE was −1.9 ± 2.3 D. Our results were higher than the 287 ± 76 μ m measured with Heidelberg SD-OCT in a study of thirty-four healthy American subjects that was reported Margolis and Spaide [13].…”

Section: Discussionsupporting

confidence: 90%

“…However, the study population is younger than ours and the mean baseline CT is thicker. Toyokawa et al [22] reported a significant diurnal variation of 20 μ m, with the thickest being in the evening, although the baseline choroidal thickness is the same and the study population was older than ours. In studies by Usui et al [18] and Tan et al [19], the mean choroidal thickness decreased during day while Chakraborty et al [24] and Toyokawa et al's [22] population showed an increase.…”

Section: Discussioncontrasting

confidence: 58%

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Diurnal Choroidal Thickness Changes in Normal Eyes of Turkish People Measured by Spectral Domain Optical Coherence Tomography

Osmanbaşoğlu

Alkın

Özkaya

et al. 2013

Journal of Ophthalmology

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Purpose. To analyse the diurnal variation of central choroidal thickness (CCT) in healthy emetropic patients during working hours. Methods. Fifty healthy young emmetrpic volunteers were included in this study. CCT was measured at 9 AM and 4 PM with spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering) with enhanced depth imaging. Diurnal variation of CCT, the correlation between rigth and left eyes and the demographic factors affecting this variation were assessed. Findings. The mean CCT at 9 AM and 4 PM was 308.7 ± 64.5 μm and 308.7 ± 62 μm, respectively, with a mean diurnal amplitude of −0.03 ± 14.7 μm, ranging between −55 μm and 47 μm, the difference was statistically insignificant (P: 0.9). There were positive correlations between right and left eyes among CCT measurements at 9 AM, 4 PM and the mean amplitude of diurnal change (r: 0.65, P < 0.01; r: 0.60, P < 0.01; r: 0.45, P: 0.00, resp.). There was a statistically significant negative correlation between the magnitude of diurnal change and age (r: −0.27, P: 0.01). Conclusion. Although the mean CCT in the all group does not show significant variation during working hours, the pattern of diurnal variation may vary from person to person according to age, and there is a great harmony between the two eyes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 58%

Diurnal Choroidal Thickness Changes in Normal Eyes of Turkish People Measured by Spectral Domain Optical Coherence Tomography

Osmanbaşoğlu

Alkın

Özkaya

et al. 2013

Journal of Ophthalmology

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“…35 Moreover, subfoveal CT is, on average, 62 mm higher in men than women 35 and has a circadian variation, being slightly thicker at the end of the day. 36,37 Existing studies did not find a clear relationship between CT and systemic arterial blood pressure. 37,38 Recently, we have witnessed a growing interest for the study of the choroid in various retinal, choroidal, or optic nerve pathologies.…”

Section: Discussionmentioning

confidence: 98%

Choroidal Thickness in Nonarteritic Anterior Ischaemic Optic Neuropathy: A Study with Optical Coherence Tomography

Dias‐Santos

Ferreira

Pinto

et al. 2014

Neuro-Ophthalmology

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Nonarteritic anterior ischemic optic neuropathy (NA-AION) is the most common nonglaucomatous optic neuropathy in adults over 50 years of age. It is usually related to cardiovascular risk factors. The primary objective of this study was to evaluate choroidal thickness in patients with chronic NA-AION, and the secondary objective was to evaluate macular thickness in these patients. This cross-sectional study compared two groups: group 1 included 20 eyes of 20 patients with chronic NA-AION, and group 2 included 31 eyes of 31 healthy controls. In both groups, the choroidal thickness was measured using the enhanced depth imaging program of Heidelberg Spectralis Õ optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany). The macular thickness was also measured using the automatic software of the same device. The mean follow-up time after NA-AION in group 1 was 57.17 ± 26.92 months. The mean choroidal thickness of the posterior pole was 244.38 ± 61.03 mm in group 1 and 214.18 ± 65.97 mm in group 2 (p = 0.004). The mean macular thickness was higher in group 2. Macular thickness is reduced in eyes that had an episode of NA-AION, whereas choroidal thickness is generally higher in these eyes when compared with normal eyes. The increase in choroidal thickness may be due to a local dysfunction in vascular autoregulatory mechanisms, which may predispose to ischemic phenomena.

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“…We did not have information on carotid artery stenosis for our CAD or control groups. In addition, because we recruited patients with CAD during the afternoon clinic and control patients during both the morning and afternoon clinic, we were unable to control for diurnal variation in CTh, which is thought to be 20–30 μm from morning to evening [50–52]. However, on further analysis of our imaging timings, the average difference between time of imaging of CAD compared to controls was approximately 2 hours, which would equate to a 5 μm or less difference between the 2 groups.…”

Section: Discussionmentioning

confidence: 99%

Choroidal thickness in patients with coronary artery disease

et al. 2017

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PurposeTo evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.DesignCross-sectional.MethodsSetting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.ResultsCTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia.Conclusions and relevancePatients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD.

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Difference in Morning and Evening Choroidal Thickness in Japanese Subjects With No Chorioretinal Disease

Abstract: The choroidal thickness varies according to the time of measurement.

Cited by 29 publications

References 21 publications

Diurnal Choroidal Thickness Changes in Normal Eyes of Turkish People Measured by Spectral Domain Optical Coherence Tomography

Diurnal Choroidal Thickness Changes in Normal Eyes of Turkish People Measured by Spectral Domain Optical Coherence Tomography

Choroidal Thickness in Nonarteritic Anterior Ischaemic Optic Neuropathy: A Study with Optical Coherence Tomography

Choroidal thickness in patients with coronary artery disease

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