Difference in inhaled aerosol deposition patterns in the lungs due to three different sized aerosols

Miki, Makoto; Isawa, Toyoharu; Teshima, Takeo; Anazawa, Yoshiki; Motomiya, Masakichi

doi:10.1097/00006231-199207000-00012

Cited by 8 publications

(5 citation statements)

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“…The real deposition of particles in the human lung when inhaled depends on several factors such as particle concentration in the air, size of particles, and respiratory intensity. Also the site of deposition depends on these factors and at specific ''hot spots'' the total amount of particles deposited may locally become relatively high (Martonen et al 1992a,b;Miki et al 1992;Balásházy et al 2000). A total of 50 mL of test media were added to the particles in the test vessels before exposure during various time periods in a Stuart platform rocker S180 incubator, regulated at a temperature of 37 AE 0.5 8C, with bilinear shaking of 25 cycles per min.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Phosphate buffered saline (PBS, pH 7.4), is a standard physiological solution that mimics the ion strength of human blood serum. It is widely used in the research (Norlin et al 2002) and medical health care community (Hanawa 2004; Okazaki and Gotoh 2005) as a reference test solution for comparison of data under simulated physiological conditions. The composition and pH of the 4 different test media are given in Table 2.…”

Section: Methodsmentioning

confidence: 99%

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Bioaccessibility studies of ferro‐chromium alloy particles for a simulated inhalation scenario: A comparative study with the pure metals and stainless steel

Midander

Frutos

Hedberg

et al. 2009

Integr Envir Assess & Manag

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The European product safety legislation, REACH, requires that companies that manufacture, import, or use chemicals demonstrate safe use and high level of protection of their products placed on the market from a human health and environmental perspective. This process involves detailed assessment of potential hazards for various toxicity endpoints induced by the use of chemicals with a minimum use of animal testing. Such an assessment requires thorough understanding of relevant exposure scenarios including material characteristics and intrinsic properties and how, for instance, physical and chemical properties change from the manufacturing phase, throughout use, to final disposal. Temporary or permanent adverse health effects induced by particles depend either on their shape or physical characteristics, and/or on chemical interactions with the particle surface upon human exposure. Potential adverse effects caused by the exposure of metal particles through the gastrointestinal system, the pulmonary system, or the skin, and their subsequent potential for particle dissolution and metal release in contact with biological media, show significant gaps of knowledge. In vitro bioaccessibility testing at conditions of relevance for different exposure scenarios, combined with the generation of a detailed understanding of intrinsic material properties and surface characteristics, are in this context a useful approach to address aspects of relevance for accurate risk and hazard assessment of chemicals, including metals and alloys and to avoid the use of in vivo testing. Alloys are essential engineering materials in all kinds of applications in society, but their potential adverse effects on human health and the environment are very seldom assessed. Alloys are treated in REACH as mixtures of their constituent elements, an approach highly inappropriate because intrinsic properties of alloys generally are totally different compared with their pure metal components. A large research effort was therefore conducted to generate quantitative bioaccessibility data for particles of ferro-chromium alloys compared with particles of the pure metals and stainless steel exposed at in vitro conditions in synthetic biological media of relevance for particle inhalation and ingestion. All results are presented combining bioaccessibility data with aspects of particle characteristics, surface composition, and barrier properties of surface oxides. Iron and chromium were the main elements released from ferro-chromium alloys upon exposure in synthetic biological media. Both elements revealed time-dependent release processes. One week exposures resulted in very small released particle fractions being less than 0.3% of the particle mass at acidic conditions and less than 0.001% in near pH-neutral media. The extent of Fe released from ferro-chromium alloy particles was significantly lower compared with particles of pure Fe, whereas Cr was released to a very low and similar extent as from particles of pure Cr and stainless steel. Low release rates are a...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Bioaccessibility studies of ferro‐chromium alloy particles for a simulated inhalation scenario: A comparative study with the pure metals and stainless steel

Midander

Frutos

Hedberg

et al. 2009

Integr Envir Assess & Manag

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“…Particle size distribution depends essentially on the design of the nebuliser (Sterk et al 1984;Newman et al 1987;Dennis 1995) and it has been shown that the size distribution of nebulised aerosols is inversely proportional to the operating frequency for the UNs (Newman 1984;Atkins et al 1992) and to the pressure developed upstream from the nebulisers for the JNs (Genicot et al 1995). Although droplet size produced is of paramount importance (Miki et al 1992), it is not the only factor which influences nebulisation efficiency which is also related to factors determined by the subject inhaling the aerosolised drug. The respiratory conditions, i.e.…”

Section: Introductionmentioning

confidence: 99%

Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system

Votion¹,

Ghafir²,

Munsters³

et al. 1997

Equine Veterinary Journal

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Summary Therapeutic aerosols play an increasing role in the treatment of equine respiratory disorders. This route of delivery permits concentration of significant amounts of drugs at the site of action without unwanted high systemic concentration and resultant side effects. The efficiency of such a topical therapy depends on the quantity of inhaled drugs deposited in the lungs and, for some drugs, on the proportion retained in specific parts of the lungs. The objective of this study was to define and to compare quantitative (dose deposited) and qualitative (regional distribution) deposition of an aerosol in the equine lungs, using either an ultrasonic nebuliser (UN) currently used in human medicine or a high pressure jet nebuliser (JN) especially developed for the equine species. This comparison was possible owing to gamma‐scintigraphy, a noninvasive technique ideally suited to give information about both total and regional deposition of inhaled drugs in the respiratory tract. The quantitative study did not point out any difference between the 2 systems concerning the activity released from the nebuliser proportionally to the initial loaded dose (mean ± s.d. 45.95 ± 4.93% for the UN vs. 46.47 ± 8.49% for the JN). By contrast, the percentage of the dose released reaching the lungs was significantly lower with the UN compared to the JN (5.09 ± 0.66% vs. 7.35 ± 1.96 %). The qualitative analysis did not show any significant difference in size of aerosol deposition image between the 2 nebulisers. However peripheral deposition was significantly higher with JN compared to UN. In conclusion, both nebulisers may be used for aerosol therapy in the equine species. The ultrasonic and pneumatic nebulisation achieved drug deposition in the peripheral part of the lungs (i.e. small airways and lung parenchyma).

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“…In vivo human scintigraphic lung imaging studies with inhaled aerosols typically show high local airway deposition of aerosol doses ("hot-spots") in the 'central' ROI and beyond 3,4,5,6 .…”

Section: Introductionmentioning

confidence: 99%

Inhaled aerosol dose distribution between proximal bronchi and lung periphery

Verbanck¹,

Biddiscombe

Usmani

2020

European Journal of Pharmaceutics and Biopharmaceutics

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Difference in inhaled aerosol deposition patterns in the lungs due to three different sized aerosols

Cited by 8 publications

References 0 publications

Bioaccessibility studies of ferro‐chromium alloy particles for a simulated inhalation scenario: A comparative study with the pure metals and stainless steel

Bioaccessibility studies of ferro‐chromium alloy particles for a simulated inhalation scenario: A comparative study with the pure metals and stainless steel

Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system

Inhaled aerosol dose distribution between proximal bronchi and lung periphery

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