Difference in Hepatotoxicity of Furan-Containing Components in Cortex Dictamni Correlates the Efficiency of Their Metabolic Activation

Pan, Jie; Wu, Chutian; Tan, Rong; Liao, Yufen; Zhao, Guode; Li, Wei; Peng, Ying; Li, Weiwei; Zheng, Jiang

doi:10.2139/ssrn.4347100

Cited by 1 publication

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“…Other furanoterpenoids, such as rutaevin, limonin, obacunone, and fraxinellone, have been found in Dictamnus dasycarpus Turcz. can also be metabolically activated by P450s to generate the corresponding reactive cis-enedial intermediates [66] . The cascade reaction triggered by the metabolic activation of these furanoterpenoids leads to hepatotoxicity, representing a significant mechanism of liver injury caused by TCM.…”

Section: Furanoterpenoidsmentioning

confidence: 99%

Chemical nature of metabolic activation of natural products in traditional Chinese medicines possibly associated with toxicities

Liu,

Wang,

Liu

et al. 2024

Acupuncture and Herbal Medicine

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Ensuring the safety of traditional Chinese medicines (TCM) has perennially presented a universal challenge in the healthcare realm. Meticulous investigations into the toxicological intricacies of natural products are of paramount significance, particularly regarding the metabolic transformation of these substances and the subsequent generation of reactive intermediates. This biochemical process underlies the genesis of diverse toxic manifestations, including hepatotoxicity, nephrotoxicity, pulmonary toxicity, and genotoxicity. Compounds sorted within TCM, including pyrrolizidine alkaloids, anthraquinones, furanoterpenoids, alkenylbenzenes, bisbenzylisoquinoline alkaloids, flavonoids, and methylenedioxyphenyl derivatives, evince a spectrum of deleterious mechanisms upon metabolic activation. This review provides a comprehensive delineation of the pathways through which these compounds induce toxicity via metabolic activation. This review emphasizes the chemical mechanisms involved in the metabolic activation of natural products that may trigger a toxic cascade, rather than a superficial phenomenon. Furthermore, this study enriches the extant literature by delving into advancements in elucidating the mechanisms of toxicity engendered by metabolic activation. In conclusion, this review highlights the importance of scrutinizing the mechanisms of toxicity and provides insights into the judicious and safe use of TCM.

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Section: Furanoterpenoidsmentioning

confidence: 99%