Difference between true functional haemoglobin and pre-dialysis haemoglobin is associated with plasma volume variation: a multicentre study

Siga, Esteban; Valle, Pilar del; Galarza, Mario Jorge; Mesina, Vito; Palma, Hugo de; Coste, Raul

doi:10.1007/s11255-014-0774-2

Cited by 2 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of short-term Hb variability, several discussions addressed the estimation of a representative Hb level in ESRD patients receiving HD [21, 24, 26]. Bellizzi et al first recommended identifying anemia based on the pre-dialysis Hb level after a short interdialytic period (i.e., mid-week days) [21].…”

Section: Discussionmentioning

confidence: 99%

“…Krisper et al proposed using the Hb time-averaged concentration (Hb-tac) and developed a formula to calculate Hb-tac using the pre- and post-dialysis Hb levels [24]. Other studies estimated the required dose of ESA based on values other than the pre-dialysis Hb level [25, 26]. Siga et al reported that the estimated ESA doses based on Hb-tac or the average of pre- and post-dialysis Hb levels were significantly lower than the dose estimated based on the mid-week pre-dialysis Hb level [26].…”

Section: Discussionmentioning

confidence: 99%

“…Other studies estimated the required dose of ESA based on values other than the pre-dialysis Hb level [25, 26]. Siga et al reported that the estimated ESA doses based on Hb-tac or the average of pre- and post-dialysis Hb levels were significantly lower than the dose estimated based on the mid-week pre-dialysis Hb level [26]. Castillo et al also reported a significantly lower estimated ESA dose based on the post-dialysis Hb level [25].…”

Section: Discussionmentioning

confidence: 99%

“…For example, hydration status significantly influences the short-term Hb variability, especially in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD) [21–23]. Thus, there have been several discussions regarding determining a representative Hb value in ESRD patients, although these discussions have failed to produce a definitive conclusion [24–26]. Furthermore, the published guidelines for anemia do not firmly recommend regarding the timing of Hb measurement in ESRD patients receiving HD, given the lack of studies regarding patient outcomes according to the Hb measurement day [18, 27, 28].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Usefulness of mid-week hemoglobin measurement for anemia management in patients undergoing hemodialysis: a retrospective cohort study

et al. 2019

View full text Add to dashboard Cite

Background Short-term hemoglobin (Hb) variability related to volume status is observed in chronic kidney disease (CKD) patients receiving hemodialysis (HD). Given the lack of studies regarding outcomes according to the day of Hb sampling, the existing guidelines do not strongly recommend regarding measurement timing. Pre-dialysis mid-week sampling (Wednesday and Thursday) is preferable to minimize short-term Hb variability, although numerous HD centers perform early-week sampling (Monday and Tuesday). The different measurement days may influence the prescribed dose of erythropoiesis-stimulating agent (ESA) and related patient outcomes. We investigated changes in Hb levels and ESA doses according to the Hb measurement day among HD patients. Methods Starting September 2013, the day for pre-dialysis Hb measurement at the Asan Medical Center was changed from early-week days to mid-week days. This single-center retrospective study evaluated medical records of 92 patients who received maintenance HD between September 2012 and August 2014. Results There was no significant difference in the mean Hb levels between early-week days and mid-week days (10.71 ± 0.06 g/dL vs. 10.78 ± 0.47 g/dL, p = 0.105). However, the mean doses of darbepoetin-α on early-week days were higher than those on mid-week days (175.4 ± 72.5 μg/month vs. 163.7 ± 83.6 μg/month, p = 0.022). The mean doses of intravenous iron hydroxide sucrose for early-week measurements were also higher than those for mid-week measurements (623.0 ± 489.0 mg/year vs. 447.0 ± 505.2 mg/year, p = 0.001). The mean interdialytic weight gains were 2.81 ± 0.82 kg on early-week days and 1.99 ± 0.61 kg on mid-week days ( p < 0.001). Conclusions Compared with early-week measurements, mid-week pre-dialysis Hb measurements were significantly associated with lower ESA doses without a change in Hb levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Usefulness of mid-week hemoglobin measurement for anemia management in patients undergoing hemodialysis: a retrospective cohort study

et al. 2019

View full text Add to dashboard Cite

show abstract

Interrelationships between changes in erythropoietin, plasma volume, haemoglobin concentration, and total haemoglobin mass in endurance athletes

Sitkowski

Szyguła

Pokrywka

et al. 2018

Research in Sports Medicine

View full text Add to dashboard Cite

Interrelationships between physiological changes (Δ) in erythropoietin (EPO), plasma volume (PV), haemoglobin concentration ([Hb]), and total haemoglobin mass (tHb-mass) were examined in cyclists who trained in different altitudes. Regardless of differences in pattern of changes observed in three training locations, ΔEPO was correlated positively with ΔPV, negatively with Δ[Hb], and trivially with ΔtHb-mass. Δ[Hb] was negatively correlated with ΔPV. In the pooled data the Spearman's rank correlation coefficients were as follows: r = 0.783, P < 0.001; r = -0.704, P < 0.001; r = 0.136, P > 0.05; r = -0.813, P < 0.001, respectively. The obtained results have shown that EPO does not only regulate [Hb] by erythropoiesis stimulation but also by PV modulation, which probably aims at keeping proper level of arterial oxygen content for oxygen delivery to tissues.

show abstract

Difference between true functional haemoglobin and pre-dialysis haemoglobin is associated with plasma volume variation: a multicentre study

Abstract: Plasma volume variations play a major role in intradialytic Hb change. True functional Hb should be estimated in all patients with a weight gain higher than 1 kg.

Cited by 2 publications

References 19 publications

Usefulness of mid-week hemoglobin measurement for anemia management in patients undergoing hemodialysis: a retrospective cohort study

Usefulness of mid-week hemoglobin measurement for anemia management in patients undergoing hemodialysis: a retrospective cohort study

Interrelationships between changes in erythropoietin, plasma volume, haemoglobin concentration, and total haemoglobin mass in endurance athletes

Contact Info

Product

Resources

About