Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects

Goto, Masayoshi; Abe, Osamu; Aoki, Shigeki; Hayashi, Naoto; Miyati, Tosiaki; Takao, Hidemasa; Iwatsubo, Takeshi; Yamashita, Fumio; Matsuda, Hiroshi; Mori, Hiromu; Kunimatsu, Akira; Ino, Kenji; Yano, Keiichi; Ohtomo, Kuni; Initiative, Japanese Alzheimer’s Disease Neuroimaging

doi:10.1007/s00234-013-1193-2

Cited by 96 publications

(69 citation statements)

References 33 publications

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“…In spite of particular attentions regarding ROI delineations, inter‐individual variabilities may propagate and bias estimations. To reduce these issues, an atlas could be constituted in order to perform a more rigorous voxel‐based analysis . However in our case, anatomical variabilities (e.g.…”

Section: Discussionmentioning

confidence: 99%

Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination

et al. 2019

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Myelin imaging in the central nervous system is essential for monitoring pathologies involving white matter alterations. Various quantitative MRI protocols relying on the modeling of the interactions of water protons with myelinated tissues have shown sensitivities in case of myelin disruption. Some extracted model parameters are more sensitive to demyelination, such as the bound pool fraction (f) in quantitative magnetization transfer imaging (qMTI), the radial diffusivity in diffusion tensor imaging (DTI), and the myelin water fraction (MWF) in myelin water imaging (MWI). A 3D ultrashort echo time (UTE) sequence within an appropriate water suppression condition (Diff‐UTE) is also considered for the direct visualization of the myelin semi‐solid matrix (Diff‐UTE normalized signal; rSPF). In this paper, we aimed at assessing the sensitivities and correlations of the parameters mentioned above to an immuno‐histological study of the myelin basic protein (MBP) in a murine model of demyelination at 7 T. We demonstrated a high sensitivity of the MRI metrics to demyelination, and strong Spearman correlations in the corpus callosum between histology, macromolecular proton fraction (ρ>0.87) and Diff‐UTE signal (ρ>0.76), but moderate ones with radial diffusivity and MWF (|ρ|<0.70).

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Section: Discussionmentioning

confidence: 99%

Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination

et al. 2019

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“…Preprocessing comprised the following steps: 1) removal of the first 10 time points; 2) slice timing correction; 3) three-dimensional motion correction; 4) nonlinear registration of the high-resolution T1 structural images to the Montreal Neurological Institute (MNI) template, in which T1 structural images were segmented as white matter, gray matter, and cerebrospinal fluid using a new segment algorithm with DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra),23 followed by further structural analyses of the resulting segments; 5) spatial normalization to the Montreal Neurological Institute template; 6) resampling of images into a spatial resolution of 3×3×3 mm 3 ; 7) temporal band-pass filtering (0.01–0.08 Hz); 8) linear detrending and nuisance signal removal (white matter, cerebrospinal fluid, global signal, 6-head motion parameters, 6-head motion parameters at one time point earlier, and the 12 corresponding squared items (Friston 24-parameter model) as covariates) via multiple regression. In this study, we excluded subjects from further analysis if the translation or rotation of head movement was >2 mm or 2° in any direction; the group differences in head motion were evaluated among the patients with PHN (n=18) and the HC subjects (n=18) according to the frame-wise displacement (FD) criteria described by Van Dijk et al24…”

Section: Methodsmentioning

confidence: 99%

Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Jiang¹,

Bao

et al. 2016

JPR

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ObjectiveThe aim of this study was to explore interhemispheric intrinsic connectivity in patients with postherpetic neuralgia (PHN).MethodsWe obtained resting-state functional magnetic resonance imaging data from 18 right-handed PHN patients (11 males, 7 females; mean age, 59.67±8.41 years) and 18 well-matched healthy controls (11 males, 7 females; mean age, 38.50±7.51 years). Interhemispheric connectivity was examined using voxel-mirrored homotopic connectivity (VMHC), and seed-based functional connectivity analysis was performed.ResultsCompared with the healthy controls, the patients with PHN showed abnormally decreased homotopic connectivity in the dorsolateral prefrontal cortex and the precuneus and posterior cingulate cortex (PCUN/PCC). The decreased VMHC in the PCUN/PCC was positively correlated with the visual analog scale of PHN in the PHN patient group (ρ=0.651; P=0.006). Receiver operating characteristic (ROC) analysis revealed that the areas under the curves for the two brain regions were 0.898 for the prefrontal cortex and 0.923 for the PCUN/PCC, which indicated that the VMHC could be used to discriminate PHN patients from healthy controls. A subsequent seed-based functional connectivity analysis revealed widely disrupted intrinsic connectivity between the regions that showed local homotopic connectivity deficits and the areas subserving the default-mode network.ConclusionOur results indicated reduced interhemispheric functional connectivity in patients with PHN, which seems to be an important new avenue to investigate to better understand the nature of disconnection of the functional architecture in patients with PHN.

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“…The realigned pre and postECT images are then corrected for signal inhomogeneities (bias correction) with regard to the reference mean image. In the next step, spatial normaliza tion parameters (using Diffeomorphic Anatomic Registration Through Exponentiated Lie Algebra (DARTEL 21,22 ) are esti mated using segmentations of the mean biascorrected image. These normalization parameters are applied to the segmentations of the biascorrected, realigned pre and post ECT images.…”

Section: Vbm Proceduresmentioning

confidence: 99%

Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study

Bouckaert

Winter

Emsell

et al. 2016

jpn

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Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects

Abstract: DARTEL normalization reduces the effect of scanner, which is a major problem in multicenter studies.

Cited by 96 publications

References 33 publications

Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination

Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination

Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study

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