Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health

Diniz, Yeda S.; Cicogna, Antônio Carlos; Padovani, Carlos Roberto; Sant'Ana, Léa Silvia; Faine, Luciane Aparecida; Novelli, Ethel L. B.

doi:10.1016/j.nut.2003.10.012

Cited by 102 publications

(97 citation statements)

References 27 publications

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“…Evaluating the individual consumption of a diet rich in AGS and another in AGP, Diniz et al (2004) concluded at the end of the experiment that the group that gained more weight was the one that consumed diet rich in AGP, which was not found in this study. Brandsch et al (2006) evaluated the weight gain of three groups of animals that consumed diets containing pork, bovine, and turkey.…”

Section: Effect Of Different Diets On Lipoprotein and Hepatic Transamcontrasting

confidence: 58%

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Effect of the daily consumption of ostrich and bovine meat on the lipid metabolism in rats

Carvalho-Filho¹,

Costa²,

Bion³

et al. 2011

Ciênc. Tecnol. Aliment.

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Section: Effect Of Different Diets On Lipoprotein and Hepatic Transamcontrasting

confidence: 58%

“…Diniz et al (2004) conducted a research with rats using diets rich in AGP and AGS and concluded that the group that presented the highest food efficiency coefficient value consumed diet rich in AGP, which was not observed in this study.…”

Section: Weight Gain and Food Efficiency Coefficient Evaluationsmentioning

confidence: 56%

Effect of the daily consumption of ostrich and bovine meat on the lipid metabolism in rats

Carvalho-Filho¹,

Costa²,

Bion³

et al. 2011

Ciênc. Tecnol. Aliment.

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“…While SFA rich foods are atherogenic and reduce coronary reserve 1,3,4 , UFAs have an anti-atherogenic effect 1,5 and protect the heart against the adverse effects of acute phase myocardial infarction 5,6 . Studies on UFA have shown beneficial results in the cardiovascular system 1,5,6 , experiments have shown that diets rich in UFA and SFA cause structural and metabolic damage in the myocardium [6][7][8][9][10] . While both diets cause disorganized sarcolemma, lipid deposits 9,10 , and myocardial oxidative stress 6,10 , the UFA rich diet also promotes necrosis 7 and abnormal muscle striation 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Studies on UFA have shown beneficial results in the cardiovascular system 1,5,6 , experiments have shown that diets rich in UFA and SFA cause structural and metabolic damage in the myocardium [6][7][8][9][10] . While both diets cause disorganized sarcolemma, lipid deposits 9,10 , and myocardial oxidative stress 6,10 , the UFA rich diet also promotes necrosis 7 and abnormal muscle striation 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Although literature shows that UFA rich diets cause morphometabolic alterations [6][7][8][9][10] , information is contradictory with respect to their effects on myocardium mechanical function 7,9,[11][12][13][14][15] . Although previous studies have shown that diet caused depressed cardiac function depression in isolated rabbit 12 and rat 13 papillary muscle, recent data from our laboratory 15 have shown that, in agreement with other authors 7,9,11,14 , UFA diet does not alter functional performance.…”

Section: Introductionmentioning

confidence: 99%

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Influências de dietas ricas em ácidos graxos saturados e insaturados sobre o miocárdio de ratos

Pinotti¹,

Dal-Pai-Silva²,

Sugizaki³

et al. 2007

Arq. Bras. Cardiol.

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SummaryObjectives: To study the influence of saturated (SFA) and unsaturated fatty acid (UFA) rich diets on mechanical function, morphology and oxidative stress in rat myocardium.Methods: Male, 60-day-old Wistar rats were fed a control (n=8), a SFA (n=8), or a UFA-rich diet (n=8) for sixty days. Mechanical function was studied in isolated left ventricle papillary muscle under isometric and isotonic contractions, in basal conditions (1.25mM calcium chloride) and after 5.2mM calcium chloride and beta-adrenergic stimuli with 1.0µM isoproterenol. Left ventricle fragments were used to study oxidative stress and morphology under light and electron microscopy.Results: SFA and UFA-rich diets did not change myocardium mechanical function. Both diets caused oxidative stress, with high lipid hydroperoxide and low superoxide-dismutase concentrations. UFA rich diet decreased catalase expression and SFA rich diet decreased the amount of myocardial glutathione-peroxidase. Both diets promoted light ultrastructural injuries such as lipid deposits and cell membrane injuries.Conclusion: Results suggest that SFA and UFA rich diets do not alter isolated muscle mechanical function, but promote light myocardial morphological injuries and oxidative stress.

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Role of Fatty Acid Chemical Structures on Underlying Mechanisms of Neurodegenerative Diseases and Gut Microbiota

Koçanci

2021

Euro J Lipid Sci & Tech

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Neurodegenerative diseases have been found to be closely related to common mechanisms such as protein aggregation, neural oxidative stress, neuroinflammation, mitochondrial dysfunction, and gut microbiota dysbiosis. Although there are some drugs that can temporarily reduce symptoms, there is no cure for these diseases. Therefore, the discovery of molecules that can halt the pathology of these diseases is urgently needed in the present time. Fatty acids show positive effects on the pathology of neurodegenerative diseases, depending on the degree of unsaturation and the shortness of the hydrocarbon chain. Understanding the effects of different structures of fatty acids on the underlying mechanisms of neurodegenerative diseases and the balance of gut microbiota can produce positive implications for the development of future treatments. The present review focuses on the role of different fatty acids on underlying mechanisms of neurodegenerative diseases, gut microbiota balance, and gut–brain axis.

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Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health

Cited by 102 publications

References 27 publications

Effect of the daily consumption of ostrich and bovine meat on the lipid metabolism in rats

Effect of the daily consumption of ostrich and bovine meat on the lipid metabolism in rats

Influências de dietas ricas em ácidos graxos saturados e insaturados sobre o miocárdio de ratos

Role of Fatty Acid Chemical Structures on Underlying Mechanisms of Neurodegenerative Diseases and Gut Microbiota

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