Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial

Annuzzi, Giovanni; Bozzetto, Lutgarda; Costabile, Giuseppina; Giacco, Rosalba; Mangione, Anna; Anniballi, G.; Vitale, Marilena; Vetrani, Claudia; Cipriano, Paola; Corte, G. Della; Pasanisi, Fabrizio; Riccardi, Gabriele; Rivellese, Angela Albarosa

doi:10.3945/ajcn.113.073445

Cited by 117 publications

(96 citation statements)

References 27 publications

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“…This agrees with the results of previous studies that have shown that other food-based antioxidants can improve glycemic control in healthy subjects as in those with T2DM [13,14,16,18]. Research suggests that antioxidants may reduce blood glucose levels by affecting carbohydrate digestion in the small intestine due to inhibition of α-glucosidase in gut mucosa [19,23] or inhibition of -amylase, a key enzyme for breaking down starch [23].…”

Section: Discussionsupporting

confidence: 82%

“…It has been proposed that certain phenolic compounds present in antioxidant-rich extracts may improve the status of at-risk individuals by ameliorating oxidative stress [18,42], improving insulin sensitivity [22], enhancing the capacity of adipocytes and skeletal muscle for glucose uptake [43,44] and by directly regulating the expression of genes related to the glycemic control [23,44,45]. It has been reported that propolis may enhance the activity of key antioxidant enzymes [46] such as superoxide dismutase, catalase and glutathione peroxidase.…”

Section: Discussionmentioning

confidence: 99%

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The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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Background: Obesity and diabetes are highly prevalent in Western countries. Both of these conditions can be associated with impaired glucose control and hyperglycemia. Studies have identified that antioxidants have the ability to regulate blood glucose levels. However, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. Thus, this study aimed to measure the effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals. Methods:Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed five different high-antioxidant food extracts (one per session, each >48 hours apart) that were matched for total antioxidant content 10 mins prior to ingestion of 50 g of available carbohydrate from either a glucose load or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours and the incremental area under the glucose curve (IAUC) was also measured. The IAUC values for the test foods were compared to the glucose-only and bread-only controls.Results: Amla berry-, grape seed-rooibos tea-and green tea-extracts as well as propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25-40% compared to the glucose-only or white bread controls (all p < 0.05). Conclusion:Antioxidants are able to modulate postprandial glucose responses in healthy subjects. These results suggest that further research is warranted to determine whether these antioxidant-rich foods are beneficial to people with prediabetes or type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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“…Although herbal infusions do not have any particular nutritional value, they represent an important source of bioactive compounds such as polyphenols. It has been shown that these compounds can act by diverse mechanisms providing signifi cant protection against chronic diseases (2). For example, the consumption of some herbal polyphenols with antioxidant activity may regulate hypertension through inhibition of the angiotensin-converting enzyme (ACE), a key component in the renin-angiotensin aldosterone system which regulates blood pressure (3).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Angiotensin-Converting Enzyme Inhibitory Activity of Eucalyptus camaldulensis and Litsea glaucescens Infusions Fermented with Kombucha Consortium

Gamboa‐Gómez¹,

González‐Laredo²,

Gallegos‐Infante³

et al. 2016

Food Technol. Biotechnol.

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SummaryPhysicochemical properties, consumer acceptance, antioxidant and angiotensin-converting enzyme (ACE) inhibitory activities of infusions and fermented beverages of Eucalyptus camaldulensis and Litsea glaucescens were compared. Among physicochemical parameters, only the pH of fermented beverages decreased compared with the unfermented infusions. No relevant changes were reported in consumer preference between infusions and fermented beverages. Phenolic profi le measured by UPLC MS/MS analysis demonstrated signifi cant concentration changes of these compounds in plant infusions and fermented beverages. Fermentation induced a decrease in the concentration required to stabilize 50 % of DPPH radical (i.e. lower IC 50 ). Additionally, it enhanced the antioxidant activity measured by the nitric oxide scavenging assay (14 % of E. camaldulensis and 49 % of L. glaucescens); whereas relevant improvements in the fermented beverage were not observed in the lipid oxidation assay compared with unfermented infusions. The same behaviour was observed in the inhibitory activity of ACE; however, both infusions and fermented beverages had lower IC 50 than positive control (captopril). The present study demonstrated that fermentation has an infl uence on the concentration of phenolics and their potential bioactivity. E. camaldulensis and L. glaucescens can be considered as natural sources of biocompounds with antihypertensive potential used either as infusions or fermented beverages.

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“…With regard to total phenol content in the drink prepared with Nativanox® Colombian tropical fruits and triglycerides and VLDL-cholesterol, a negative correlation was found, indicating that the higher concentration of total phenols lower levels of these parameters. These effects on triglycerides and VLDL has been observed in people following diets naturally rich in polyphenols (2776 to 2903 mg) for 8 weeks (Annuzzi et al, 2014) that significantly reduced fasting triglyceride concentrations (2-factor ANOVA) in plasma (P = 0.023) and large very-low-density lipoproteins (VLDLs) (P = 0.016) and postprandial triglyceride total area under the curve in plasma (P = 0.041) and large VLDLs (P = 0.004) (Anuzzi et al, 2014).…”

Section: Discussionmentioning

confidence: 90%

Impact of Colombian yellow fruits and tropical fruits drinks consumption on the antioxidant status of healthy women

Gómez-García¹,

Peñaloza²,

Canas³

et al. 2016

J. Med. Plants Res.

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Reactive oxygen species are responsible for causing different types of damage in the body which are associated with the onset of chronic non-communicable diseases. A strategy to counteract these effects is by a diet rich in antioxidants compounds found in fruits. The aim of this study was to determine the antioxidant capacity in plasma and the content of total phenolic compounds in healthy women who consumed a drink prepared with Nativanox® Colombian tropical fruits or a drink prepared with Nativanox® Colombian yellow fruits during a short period of time. Nineteen healthy women received a daily 200 mL drink with Nativanox® Colombian tropical fruits or a drink with Nativanox® Colombian yellow fruits for 14 days. Before and after the intervention period blood and plasma were obtained to analyze C-reactive protein levels, lipid profile, total phenolic content and antioxidant status through FRAP, ABTS and EROS methods. Regular consumption of a drink with Nativanox® Colombian tropical fruits had a positive impact on the lipid profile and the antioxidant capacity on plasma of healthy women. The consumption of a drink with Nativanox® Colombian yellow fruits diminished diastolic blood pressure. These results showed that a Nativanox® Colombian yellow and tropical fruit contains bioactive compounds that can improve oxidative status in plasma and contribute to reduce the risk of cardiovascular disease.

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Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial

Cited by 117 publications

References 27 publications

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Antioxidant and Angiotensin-Converting Enzyme Inhibitory Activity of Eucalyptus camaldulensis and Litsea glaucescens Infusions Fermented with Kombucha Consortium

Impact of Colombian yellow fruits and tropical fruits drinks consumption on the antioxidant status of healthy women

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