Diethylstilbestrol exposure in utero: Review of literature

Glaze, Gary M.

doi:10.1515/jom-1984-840214

Cited by 2 publications

(2 citation statements)

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“…The primary indication for diethylstilbestrol prescription was, however, both the prevention of miscarriage in pregnant women and the treatment of menopause and estrogen-deficiency symptoms. The administration of this molecule in pregnant women shows the potential to correlate with a variety of structural abnormalities on the progeny, including congenital genitourinary abnormalities in males, such as varicocele, cryptorchidism and testicular hypoplasia, which can lead to infertility [56].…”

Section: Discussionmentioning

confidence: 99%

The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

Baldini,

Khattak,

Capogrosso

et al. 2023

Brain Sciences

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Background: A wide range of medications may have a possible role in the development of male-factor infertility (MFI), including various antineoplastic agents, testosterone/anabolic steroids, immunosuppressive drugs/immunomodulators, glucocorticosteroids, non-steroidal anti-inflammatory drugs, opiates, antiandrogenic drugs/5-alpha-reductase inhibitors, various antibiotics, antidepressants, antipsychotics, antiepileptic agents and others. We aimed at investigating this issue from a pharmacovigilance-based perspective. Methods: The Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was queried to identify the drugs associated the most with MFI individual reports. Only those drugs being associated with more than 10 MFI reports were considered for the disproportionality analysis. Proportional Reporting Ratios (PRRs) and their confidence intervals were computed for all the drugs identified in this way in January 2023. Secondary, ‘unmasking’, dataset analyses were carried out as well. Results: Out of the whole database, 955 MFI reports were identified, 408 (42.7%) of which were associated with 20 medications, which had more than 10 reports each. Within this group, finasteride, testosterone, valproate, diethylstilbestrol, mechloretamine, verapamil, lovastatin and nifedipine showed significant levels of actual disproportionate reporting. Out of these, and before unmasking, the highest PRR values were identified for finasteride, diethylstilbestrol and mechloretamine, respectively, with values of 16.0 (12.7–20.3), 14.3 (9.1–22.4) and 58.7 (36.3–95.9). Conclusions: A variety of several medications, a number of which were already supposed to be potentially linked with MFI based on the existing evidence, were associated with significant PRR levels for MFI in this analysis. A number of agents which were previously hypothesized to be associated with MFI were not represented in this analysis, suggesting that drug-induced MFI is likely under-reported to regulatory agencies. Reproductive medicine specialists should put more effort into the detection and reporting of these adverse drug reactions.

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Section: Discussionmentioning

confidence: 99%

The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

Baldini,

Khattak,

Capogrosso

et al. 2023

Brain Sciences

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“…Some studies have provided novel insight into the molecular basis for spermiation failure and apoptosis caused by 17beta-estradiol and also offer new mechanisms by which adult exposure to environmental estrogens can affect spermatogenesis and fertility [24]. Studies on boys delivered by mothers treated with diethylstilbestrol, a very potent estrogen agonist from 1950 to 1970, have reported alterations in sperm quality and higher incidence of genital malformations, cryptorchidism, and testicular cancer compared to the control population [25][26]. Estrogenic drugs administered by injections, oral gavage, or via drinking water have been claimed to result in varied effects such as decreased Sertoli cell number, Leydig cell hyperplasia, decreased sperm count and testicular weight [27][28].…”

Section: Introductionmentioning

confidence: 99%

Estrogenic and Hypocholesterolemic Effects of Aqueous Extract of Nicotiana tabacum (Tobacco) on the Micro-Anatomical Architecture of the Testis in Male Albino Wistar Rats

Okoye¹

2014

BJAST

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Aim:The aim of this study was to investigate the effect of aqueous extract of Nicotiana tabacum on the testicular function and micro-architectural integrity in male Albino Wistar rats in relation to the serum concentrations of estradiol, cholesterol, testis and body weights. Study Design: The experiment was carried out on Albino Wistar Rats. Methodology: A total of 18 male Albino Wistar rats aged 8 to 10 weeks and weighing 140 to 220 g was used. Aqueous extract of N. tabacum at the doses of 20 and 30 mg/kg body weight were orally administered to groups B and C, respectively while 0.5 ml of distilled water was administered to group A (Control) for 28days. Serum concentration of estradiol (E2) and total cholesterol were estimated using the microplate enzyme

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Diethylstilbestrol exposure in utero: Review of literature

Cited by 2 publications

References 0 publications

The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

Estrogenic and Hypocholesterolemic Effects of Aqueous Extract of Nicotiana tabacum (Tobacco) on the Micro-Anatomical Architecture of the Testis in Male Albino Wistar Rats

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