Diethylpropion in the Treatment of "Refractory" Obesity

Weight-reducing Effect of Diguanides in Obese Non-diabetic Women

“…From the practical point of view the mean weight loss during diguanide treatment was similar to that obtained by dextroamphetamine and some of its congeners in comparable patients with refractory obesity (Duncan et al, 1960;Seaton et al, 1961Seaton et al, , 1964aSeaton et al, , 1964bMunro et al, 1966). As with these drugs, the weight-reducing effect of the diguanide may be temporary, but a longer study is required to establish this point.…”

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

“…In a more historic meta-analysis comprising 13 clinical studies published between 1965 and 1983, treatment with diethylpropion for 6-52 weeks in a dose of 75 mg/d resulted in a placebo-subtracted average weight loss of 3.0 kg with borderline significance to placebo controls (Li et al, 2005). Notably, although several reports testify that diethylpropion has an anorexigenic nature with virtual absence of adverse effects (Wilson and Long, 1960;Hadden and Lucey, 1961;Nash, 1961;Seaton et al, 1961), there is at least one report of diethylpropion addiction (Clein and Benady, 1962).…”

Long-term Pharmacotherapy of Obesity 2000

“…Overall, data for long-term diethylpropion treatment are limited to 30 patients at 6 months and 5 patients at 12 months. Although it may have the least stimulant adverse effects among the noradrenergic agents, 31 a relatively rapid tolerance to its anorectic effects has been observed 35 while weight loss beyond 6 months has not.…”