Diethylhydrogensilyl-cyclic diethylsilylene derivatives in the gas chromatography-mass spectrometry of hydroxylated steroids IV. Hydrocortisone

Ishibashi, Masataka; Irie, Tsuyoshi; Miyazaki, Hiroshi

doi:10.1016/0021-9673(87)80067-5

Cited by 2 publications

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“…The reaction of the diethylsilyl analog of BSTFA also readily formed a cyclic diethylsilylene derivative with alkyloxime derivatives of cortisol (11β,17α,21‐trihydroxypregn‐4‐en‐3,20‐dione, 258 ) (Ishibashi et al, ). The spectrum of the methyloxime derivative showed an abundant molecular ion and a base peak corresponding to loss of OCH 3 from the oxime.…”

Section: Other Silyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Section: Other Silyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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“…The derivatives thus prepared are suitable for determining various saccharides (including acidic) by GC/EI-MS. 125 A further approach to the mixed derivatization of polyols, for example, in the steroid and prostaglandin series is reaction with N,O-bis(diethylhydrogensilyl)trifluoro acetamide in the presence of BSTFA. 126,127 In this case, closely disposed hydroxyls form cyclic adducts whereas silyl ethers are formed for remote OH groups. Some EI mass spectral features of such derivatives in a steroid series have been elucidated with the aid of labeling experiments, metastable ion analysis and accurate mass measurements Essentially the same derivatization (except that silylation was performed with TMSIM) and mass spectrometric methodology were used for quantitation of 17β-estradiol, estrone, 17α-ethynylestradiol and 16α-hydroxy-17β-etradiol (estriol) in ground water and swine lagoon samples.…”

Section: Mixed Derivatives Of Polyols and Compounds Containing Both Pmentioning

confidence: 99%

Derivatization in Mass Spectrometry—6. Formation of Mixed Derivatives of Polyfunctional Compounds

Заикин

Halket

2005

Eur J Mass Spectrom (Chichester)

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The review describes chemical transformations of multifunctional compounds (amino acids and peptides, amino alcohols, amino thiols, hydroxy acids, oxo acids, oxo alcohols, compounds containing simultaneously three or more different groups etc.) by using step-wise or one-step modification or protection of functional groups. Some chemical aspects of mixed derivatization performed for improving the physical-chemical properties and mass spectral characteristics are discussed. Application of mixed derivatization to qualitative and quantitative analysis of various multifunctional compounds mainly in biological fluids and other matrices by gas chromatography/mass spectrometry in electron ionization, chemical ionization, negative-ion chemical ionization and selected ion monitoring modes is considered.

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Diethylhydrogensilyl-cyclic diethylsilylene derivatives in the gas chromatography-mass spectrometry of hydroxylated steroids IV. Hydrocortisone

Cited by 2 publications

References 0 publications

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Derivatization in Mass Spectrometry—6. Formation of Mixed Derivatives of Polyfunctional Compounds

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