2020
DOI: 10.21577/0103-5053.20200009
|View full text |Cite
|
Sign up to set email alerts
|

Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders

Abstract: This study describes a single step, high yield and purity, ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 × 10 7 M −1 s −1) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC 50) = 23.07 µM) but not with superoxide anion radical or hydrogen peroxide … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
1
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 39 publications
0
1
0
Order By: Relevance
“…More recently, Dos Santos and co‐workers developed a simple and scalable diethyl selenodiglycolate as an antioxidant agent, and have demonstrated the oxidation product formed when this target was reacted with HClO [168] . In this study, HRMS and 77 Se NMR analyses have shown the same oxidized form of selenium (Scheme 39).…”
Section: Additional Information Through Organoselenium Compoundsmentioning
confidence: 55%
“…More recently, Dos Santos and co‐workers developed a simple and scalable diethyl selenodiglycolate as an antioxidant agent, and have demonstrated the oxidation product formed when this target was reacted with HClO [168] . In this study, HRMS and 77 Se NMR analyses have shown the same oxidized form of selenium (Scheme 39).…”
Section: Additional Information Through Organoselenium Compoundsmentioning
confidence: 55%
“…The organoselenium compound acetylselenide showed low selenium contents in the plants, yet it increased the antioxidant action. Selenium-containing compounds were designed and synthesized based on their ability to scavenge oxidants [21]. An example of the best-known synthetic compound that can counteract oxidative species is Ebselen, which has high antioxidants [46].…”
Section: Discussionmentioning
confidence: 99%
“…Potassium hydroxy-selenide was prepared according to patent WO 2015/155453A2; Acetylselenide was prepared according to the procedure previously reported by Pinatto-Botelho et al [21].…”
Section: Synthesis Of Selenium-containing Compoundsmentioning
confidence: 99%