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Abstract:The title compound, C26H28NO3P, crystallized with two independent molecules in the asymmetric unit. The structural features (bond lengths and angles) of the two molecules are almost identical. The interplanar angle between the anthracene and toluidine rings is similar in the two molecules, with values of 82.92 (5) and 80.70 (5)°. In the crystal, both molecules form inversion dimers linked by pairs of N—H⋯O hydrogen bonds. Three of the four ethyl groups are disordered over two sets of sites, the major compo… Show more
“…Poly(oxyehtylene aminophosphonate)s 1–4 ( Figure 1 ) were synthesized through an addition of poly(oxyehtylene H-phosphonate)s to the Schiff bases, N , N -dimethyl- N ′’-furfurylidene-1,3-diaminopropane [ 11 ] and N -(4-dimethylaminobenzylidene)- p -toluidine,[ 10 ] respectively. Figure 1.…”
Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were tested in vitro for antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells and in vivo for clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, both in vivo and in vitro and lower clastogenicity in vivo than the corresponding low-molecular aminophosphonates. The biological activities of the tested polymers correlate with their low in vitro antitumor activity.
“…Poly(oxyehtylene aminophosphonate)s 1–4 ( Figure 1 ) were synthesized through an addition of poly(oxyehtylene H-phosphonate)s to the Schiff bases, N , N -dimethyl- N ′’-furfurylidene-1,3-diaminopropane [ 11 ] and N -(4-dimethylaminobenzylidene)- p -toluidine,[ 10 ] respectively. Figure 1.…”
Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were tested in vitro for antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells and in vivo for clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, both in vivo and in vitro and lower clastogenicity in vivo than the corresponding low-molecular aminophosphonates. The biological activities of the tested polymers correlate with their low in vitro antitumor activity.
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