“…One of these 3 patients was the only subject over 70 years old included, and her advanced age may have directly affected the glucose tolerance test (26,27). The fourth patient in the group was suffering from arthritis, and it has been repeatedly reported (28,29,30) that most of the patients with this disease have abnormal glucose tolerance curves. However, 3 other patients with arthritis showed an improvement in tolerance following the period of therapy, and it is probably not proper to place great emphasis upon the presence of this disease as an explanation of the failure in this instance.…”