Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms

Cruz, Raquel Santana da; Andrade, Fábia de Oliveira; Carioni, Vivian Montes de Oca; Rosim, Mariana; Miranda, Mayara Lilian Paulino; Fontelles, Camile Castilho; Oliveira, Pedro Vitoriano de; Barbisan, Luı́s Fernando; Castro, Inar Alves de; Ong, Thomas Prates

doi:10.1016/j.fct.2019.110813

Cited by 11 publications

(4 citation statements)

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“…Another study reports that maternal protein restriction in gestation and lactation is associated with low birth weight, catch-up growth after birth, and increased breast cancer risk in offspring, particularly in the presence of a high-calorie diet in adulthood ( 34 , 36 ). More recently, a study showed that both excess and deficiency of dietary zinc during gestation is associated with higher breast carcinogenesis in daughters ( 37 ).…”

Section: Developmental Origins Of Breast Cancermentioning

confidence: 99%

Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline

et al. 2020

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The past decade has made evident that in addition to passing their genetic material at conception, parents also transmit a molecular memory of past environmental experiences, including nutritional status, to their progeny through epigenetic mechanisms. In the 1990s, it was proposed that breast cancer originates in utero. Since then, an overwhelming number of studies in human cohorts and animal models have provided support for that hypothesis. It is becoming clear, however, that exposure in the parent generation can lead to multigenerational and transgenerational inheritance of breast cancer. Importantly, recent data from our lab and others show that pre-conception paternal diets reprogram the male germline and modulate breast cancer development in offspring. This review explores the emerging evidence for transgenerational epigenetic inheritance of breast cancer focusing on studies associated with ancestral nutritional factors or related markers such as birth weight. We also explore paternal factors and the epigenetic mechanisms of inheritance through the male germline while also reviewing the existing literature on maternal exposures in pregnancy and its effects on subsequent generations. Finally, we discuss the importance of this mode of inheritance in the context of breast cancer prevention, the challenges, and outstanding research questions in the field.

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Section: Developmental Origins Of Breast Cancermentioning

confidence: 99%

Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline

et al. 2020

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“…The results indicate that the tumorigenesis and development of breast cancer are closely related to zinc-ion binding, which is consistent with the findings in previous studies ( 37 – 39 ). Many studies have found that zinc is significantly correlated with the carcinogenesis of various tissues and cells in the body, and a change in the zinc content in the human body is closely related to the occurrence and development of tumors ( 40 – 42 ). In addition, zinc deficiency can cause immune dysfunction, which can enhance the inflammatory effects of interleukin, inhibit the effects of interleukin on lymphocytes, and promote apoptosis, angiogenesis, and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer

Fan

Kao

et al. 2022

Front. Oncol.

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BackgroundWith the rapid development and wide application of high-throughput sequencing technology, biomedical research has entered the era of large-scale omics data. We aim to identify genes associated with breast cancer prognosis by integrating multi-omics data.MethodGene-gene interactions were taken into account, and we applied two differential network methods JDINAC and LGCDG to identify differential genes. The patients were divided into case and control groups according to their survival time. The TCGA and METABRIC database were used as the training and validation set respectively.ResultIn the TCGA dataset, C11orf1, OLA1, RPL31, SPDL1 and IL33 were identified to be associated with prognosis of breast cancer. In the METABRIC database, ZNF273, ZBTB37, TRIM52, TSGA10, ZNF727, TRAF2, TSPAN17, USP28 and ZNF519 were identified as hub genes. In addition, RPL31, TMEM163 and ZNF273 were screened out in both datasets. GO enrichment analysis shows that most of these hub genes were involved in zinc ion binding.ConclusionIn this study, a total of 15 hub genes associated with long-term survival of breast cancer were identified, which can promote understanding of the molecular mechanism of breast cancer and provide new insight into clinical research and treatment.

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“…In addition, a three to twenty fold increase in the transcript abundance of repetitive elements (Iap, Line1, Sineb1, Sineb2) was observed, accompanied by an aberrant decrease in oocytes specific Gdf9, Zp3 and Figla mRNAs. A recent study has shown that a maternal Zn deficiency during development could increase the susceptibility to development of breast cancer in a female mouse model [88]. Molecular and epigenetic dysregulation were detected in the adult mammary gland of the offspring, underscoring the potential long-term pathological consequences of gestational Zn deficiency.…”

Section: Origin Of Late Developmental Effectsmentioning

confidence: 98%

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

Willekens

Runnels

2022

Nutrients

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The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence scores of metabolic processes in cells throughout the body. Deficiency of Zn in humans has a profound effect on development and in adults later in life, particularly in the brain, where Zn deficiency is linked to several neurological disorders. In this review, we will summarize the importance of Zn during development through a description of the outcomes of both genetic and early dietary Zn deficiency, focusing on the pathological consequences on the whole body and brain. The epidemiology and the symptomology of Zn deficiency in humans will be described, including the most studied inherited Zn deficiency disease, Acrodermatitis enteropathica. In addition, we will give an overview of the different forms and animal models of Zn deficiency, as well as the 24 Zn transporters, distributed into two families: the ZIPs and the ZnTs, which control the balance of Zn throughout the body. Lastly, we will describe the TRPM7 ion channel, which was recently shown to contribute to intestinal Zn absorption and has its own significant impact on early embryonic development.

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Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms

Cited by 11 publications

References 44 publications

Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline

Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline

Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

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