Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice

Kurz, Bodo; Jost, Bernard; Schünke, Michael

doi:10.1053/joca.2001.0489

Cited by 95 publications

(55 citation statements)

References 38 publications

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“…Also, dietary vitamins diminished the development of mechanically induced OA and increased the expression of antioxidative enzymes in the knee joint of STR/1N mice (41). However, other investigators have reported conflicting results for the effects of antioxidants on OA (42,43). More data are required to confirm that a supplementary antioxidant diet is effective in reducing OA symptoms.…”

Section: Discussionmentioning

confidence: 98%

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

Cillero‐Pastor¹,

Caramés²,

Lires-Deán³

et al. 2008

Arthritis & Rheumatism

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Objective. Mitochondrial alterations play a key role in the pathogenesis of osteoarthritis (OA). This study evaluated a potential role of mitochondrial respiratory chain (MRC) dysfunction in the inflammatory response of normal human chondrocytes.Methods. Commonly used inhibitors of the MRC were utilized to induce mitochondrial dysfunction in normal human chondrocytes. Levels of prostaglandin E 2 (PGE 2 ) protein and expression of cyclooxygenase 2 (COX-2) and COX-1 messenger RNA (mRNA) and protein were analyzed. To identify the underlying mechanisms responsible for PGE 2 liberation, reactive oxygen species (ROS) were measured. Inhibitors of ROS, including vitamin E, and inhibitors of mitochondrial Ca 2؉ and NF-B were used to test their effects on the MRC.Results. Antimycin A and oligomycin (inhibitors of mitochondrial complexes III and V, respectively) significantly increased the levels of PGE 2 (mean ؎ SEM 505 ؎ 132 pg/50,000 cells and 288 ؎ 104 pg/50,000 cells, respectively, at 24 hours versus a basal level of 29 ؎ 9 pg/50,000 cells; P < 0.05) and increased the expression of COX-2 at both the mRNA and protein levels. Expression of COX-1 did not show any modulation with either inhibitor. Further experiments revealed that antimycin A and oligomycin induced a marked increase in the levels of ROS.

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Section: Discussionmentioning

confidence: 98%

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

Cillero‐Pastor¹,

Caramés²,

Lires-Deán³

et al. 2008

Arthritis & Rheumatism

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“…Increased vitamin C intake has also been shown to exhibit a slight chondroprotective effect (P 5 0?08) on the development of spontaneous lesions in guinea pigs, with no such effect on the progression of surgically induced OA (18) . The findings of Kurz et al (4) demonstrated a similar positive association between antioxidant supplements (vitamins A, C, E, B 6 , B 2 and selenium) and reduced incidence of knee OA in OA-prone mice. It was found that the supplemented diet induced a 1?5-fold increase in enzymatic antioxidant activity, with the authors concluding that the selected combination of vitamins and selenium diminished the mechanical induction of OA in mice.…”

Section: Discussionmentioning

confidence: 68%

“…It has been commonly hypothesised that mechanical stress on the joints may lead to free radical accumulation and subsequent articular cartilage degradation, leading to OA symptoms (4,25) . This presents the possibility that the consumption of antioxidants may reduce the incidence of OA by preventing or minimising the occurrence of oxidative cartilage damage.…”

Section: Discussionmentioning

confidence: 99%

“…Damage caused by free radicals has long been thought to be pathogenic and they play an important role in the progression of many chronic diseases, including CVD and osteoarthritis (OA) (1)(2)(3)(4)(5)(6) . Free radicals are unstable, reactive molecules with unpaired electrons that are primarily created via the aerobic metabolism and the immune response to antigen.…”

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confidence: 99%

“…In fact, although OA is defined as a 'non-inflammatory arthropathy', there is evidence that pro-inflammatory molecules play an important role as mediators in the pathogenesis of OA (8,9) . Thus, there is significant scientific interest in studying the efficacy of nutritional therapeutics to combat such chronic diseases, specifically dietary antioxidants such as vitamin C. In addition to its antioxidant capacity, vitamin C is critical to bone health, acting as an electron donor in the synthesis of type II collagen (4)(5)(6) . It is also a sulfate carrier in glycosaminoglycan synthesis.…”

mentioning

confidence: 99%

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The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

Peregoy

Wilder

2010

Public Health Nutr.

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Objective: To evaluate the association between vitamin C supplementation and the incidence and progression of radiographic knee osteoarthritis (OA). Design: Prospective cohort study. Setting: Clearwater Osteoarthritis Study (COS): (1988 to the present) a longitudinal study. Subjects: Male and female COS participants aged 40 years and above (n 1023). The study exposure was the participants' self-reported history of vitamin C supplementation. The participants underwent biennial, sequential knee radiographs, which were assessed using the Kellgren-Lawrence ordinal scale to determine evidence of the study 2 outcomes: incident radiographic knee OA (RKOA) and progression of RKOA. Results: Individuals without baseline knee OA who self-reported vitamin C supplement usage were 11 % less likely to develop knee OA than were those individuals who self-reported no vitamin C supplement usage (risk ratio (RR) 5 0?89, 95 % CI 0?85, 0?93). Among those participants with RKOA at baseline, vitamin C supplement usage did not demonstrate an association with RKOA progression (RR 5 0?94, 95 % CI

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New Drugs and Nutraceuticals in the Treatment of Osteoarthritis

Henrotin

Reginster

2011

Pharmaceutical Sciences Encyclopedia

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Osteoarthritis is a disease with a multifactorial etiology affecting all joint tissues and involving both biochemical and mechanical factors that act in synergy to degrade cartilage. Until now, OA treatments are limited to pain relief, even if some new drugs of the SYSADOA class have shown potential structure‐modifying effects. These drugs target cartilage as the endpoint of joint failure, underestimating the role played by subchondral bone and synovium in this process. However, recent studies emphasized the key role played by subchondral bone sclerosis and synovium inflammation in OA pathophysiology. Unfortunately, until now, there is no validated method for a reliable assessment of structural changes in these tissues, explaining that guidance documents edited by the official agencies and scientific societies are strictly focused on the assessment of cartilage changes.

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Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice

Abstract: A diet supplemented with vitamins/selenium might be important in prevention or therapy of mechanically induced OA. We hypothesize that free oxygen radical species might be involved in the mechanical induction of OA.

Cited by 95 publications

References 38 publications

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

New Drugs and Nutraceuticals in the Treatment of Osteoarthritis

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