Dietary Vitamin K Intake and HPV-Infection Status Among American Women: A Secondary Analysis From National Health and Nutrition Examination Survey Data From 2003 to 2016

Abstract

Objective: Cervical cancer is a serious potential risk to women’s health, and is closely related to persistent HPV infection. Vitamin K mainly existed in green vegetables, fruit, and dairy products. This research aims to observe the association between vitamin K and HPV-infection.Methods: 13,447 participants from the NHANES were selected. Dietary vitamin K intake was used as the objective independent variable and continuous variable, HPV-infection status was used as the outcome variable, and characteristics of selected participants were used as the covariates.Results: There was a nonlinearity between vitamin K intake and HPV-infection, and the inflection point is 3.81 of log2 vitamin K intake. In a range of 0–3.81, Each one-unit increase in log2 vitamin K intake was associated with a 43% reduction in the risk of HPV infection. When log2 vitamin K intake excess of 3.81, the risk of HPV infection did not continue to decline. The HPV-subtype was not associated with vitamin K intake.Conclusion: There is a nonlinearity between vitamin K intake and HPV-infection status. But HPV-subtype was not associated with vitamin K intake.

Epidemiological Profile of Human Papillomavirus in a Healthcare Center in Portugal: Implications for Public Health Policies

“…Significantly, the association between smoking habits and HR-HPV infection demonstrated statistical significance (p=0.003), highlighting the potential role of lifestyle factors in influencing HR-HPV prevalence. This finding aligns with a corroborating study, underscoring the significance of the association between smoking habits and HR-HPV infection [16]. Conversely, economic insufficiency did not show a statistically significant association with HR-HPV infection (p=0.791), suggesting a more nuanced interplay of socioeconomic factors in this context.…”

“…Human papillomavirus infection (HPV) is one of the most common sexually transmitted diseases, such that most sexually active people have contact with the virus at least once in their lifetime [1][2][3][4]. More than 170 types have been identified [5], and about 14 are associated with increased risk of cancer, also known as high-risk (HR)-HPV 16,18,31,33,35,39,45,51,52,56,58,59, 66, and 68 [1]. HPV 16 is the most common.…”

The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

“…The results of this study suggest that a dietary vitamin K intake of more than 14.03 mcg may reduce the risk of HPV infection. On the contrary, HPV subtypes were not associated with vitamin K intake [118].…”

“…To conclude, evidence suggests the protective role of a higher intake and high serum levels of vitamin E against CC and the risk of dysplasia [14,98,[115][116][117][118]. Moreover, αand γtocopherol may be protective against the persistence of non-oncogenic HPV infections [115].…”

Vitamin D and Its Receptors in Cervical Cancer

“…VK can promote apoptosis, induce cell cycle arrest and overcome drug resistance by inhibiting P-glycoprotein, offering potential value when combined with VD in the treatment of cervical cancer 129 . A cross-sectional survey of more than 10,000 women in the United States suggests an association between VK intake and HPV infection, although the relationship appears non-linear 130 . VK can produce reactive oxygen species, which leads to apoptosis 131 , 132 .…”