Dietary vitamin D3 supplementation protects laying hens against lipopolysaccharide-induced immunological stress

Geng, Yunyun; Ma, Qiugang; Wang, Zhong; Guo, Yuming

doi:10.1186/s12986-018-0293-8

Cited by 40 publications

(50 citation statements)

References 84 publications

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“…The reason may contribute to that the content of vitamin D 3 (5000 IU) in diet had already met the layers' requirements in current study. It has been indicated that only when vitamin D 3 was deficient in the diet, the exogenous addition of vitamin D 3 or its analog can exert its improving effect on performance of laying hens ( Shen et al., 1981 , Goodson-Williams et al., 1986 , Geng et al., 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens

et al. 2020

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This study was conducted to determine the effects of 25-hydroxycholecalciferol ( 25-OH-D 3 ) on performance, egg quality, tibia quality, and serum hormones concentration in laying hens reared under high stocking density. A total of 800 45-week-old Lohmann laying hens were randomly allotted into a 2 × 2 factorial design with 2 levels of dietary 25-OH-D 3 levels (0 and 69 μg/kg) and 2 rates of stocking densities [506 (low density) and 338 (high density) cm 2 /hen]. Laying hens were monitored for 16 wk. High stocking density decreased laying rate, egg weight, and feed intake compared with low stocking density ( P < 0.01) during 1 to 8 wk and 1 to 16 wk. Overall, high stocking density increased eggshell lightness value and decreased shell redness and yellowness value, strength, thickness, and relative weight compared with low stocking density ( P < 0.05). Dietary supplementation with 25-OH-D 3 reduced the value of the eggshell lightness and increased its yellowness and eggshells weight ( P ≤ 0.05). The increase in eggshell thickness was more pronounced when 25-OH-D 3 was supplemented to layers under high stocking density (interaction, P < 0.05). Layers under high stocking density had lower ash content and calcium content in the tibia than layers under low stocking density ( P = 0.04); dietary 25-OH-D 3 increased tibia strength compared with no addition ( P = 0.05). Layers under high stocking density had higher serum concentrations of 25-OH-D 3 , corticosterone ( CORT ), lipopolysaccharide ( LPS ), and osteocalcin ( OC ; P < 0.05), lower content of parathyroid hormone ( PTH ) compared with layers under low stocking density ( P < 0.01). Dietary 25-OH-D 3 increased serum concentration of 25-OH-D 3 , carbonic anhydrase ( CA ), and calcitonin ( CT ) ( P < 0.01) and reduced corticosterone, lipopolysaccharide and osteocalcin concentration ( P ≤ 0.05). The increase effect in PTH was more pronounced when 25-OH-D 3 was supplemented to layers under high stocking density (interaction, P = 0.05). Overall, the results gathered in this study indicate that high stocking density result in reducing production performance, shell color and quality, and tibia health, whereas dietary 25-OH-D 3 was able to maintain tibia health and to mitigate the negative impact of high stocking density on productive performance.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens

et al. 2020

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“…Hens housed under these conditions are not exposed to adequate natural light to transform 7-dihydrocholesterol at levels appropriate for the sufficient synthesis of VD 3 . Thus, VD 3 is usually added to layer feeds; these are critical for the homeostasis of calcium and to maintain laying performance, bone calcification, and eggshell formation ( 5 , 14 , 20 ). The biosynthesis of the active form 1, 25-dihydroxycholecalciferol (1,25-(OH) 2 D 3 ) from VD 3 was reviewed by Geng et al ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Calcium and Cholecalciferol Levels in Late-Phase Laying Hens: Effects on Productive Traits, Egg Quality, Blood Biochemistry, and Immune Responses

2020

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Productive traits and immunity in laying hens decrease sharply during the late phase of laying due to aging, which negatively affects the metabolism and hormonal status of the animals. The influence of Ca levels (3.5, 4.0, and 4.5%) and/or cholecalciferol [Vitamin D 3 (VD 3 )] supplementation (800-, 1,000-, and 1,200-IU/kg diet or as total of 3,800, 4,000, and 4,200 IC VD 3 ) on performance, egg quality, blood biochemistry, and immunity of brown egg layers was investigated. Three hundred and sixty H&N Brown egg layers (60 weeks old) were allocated at random into nine nutritional treatments of five replications (cages) of eight hens each. The control diet in this experiment contained a 3.5% Ca level with 800 IU VD 3 . The addition of VD 3 at 1,000 and 1,200 IU to 3.5 and 4% Ca diets significantly ( P ≤ 0.05) increased the rate of laying, egg mass, and feed conversion ratio (FCR) compared to the control diet on 3.5% and 800 U of VD 3 . Besides this, the addition of VD 3 at 800 and 1,200 IU to 3.5% Ca level diets enhanced the Haugh unit score. Similar results were observed in eggshell quality measurements and tibia ash. Increasing the Ca concentration from 3.5 to 4 and 4.5% and increasing VD 3 levels from 800 to 1,000 or 1,200 IU significantly and similarly increased serum total protein and globulin. In addition, VD 3 at 1,000 IU increased serum albumin, compared to 800 IU. Increasing Ca level increased IgA, and 4 and 4.5% Ca levels similarly increased IgG and α-2 globulin compared to the 3.5% Ca diet. VD 3 addition at 1,200 IU to the 4% Ca diet significantly increased γ-globulin compared to 1,000 IU, but decreased β-globulin. Increasing the Ca level to 4% significantly reduced serum triglycerides, and the very low-density lipoprotein and the triglyceride/high-density lipoprotein ratio were both decreased with 4 and 4.5% Ca level diets. Increasing the Ca level caused a stepwise increase in catalase, which was markedly increased with VD 3 supplementation at 1,200 IU. Plasma estrogen was increased considerably with VD 3 supplementation at 3.5% Ca, but parathyroid hormone levels were not affected. In conclusion, increasing Ca levels in the diet of laying hens to 4% during the late production phase could be a useful tool to improve laying performance, eggshell quality, Haugh unit score, and physiological and immunological status. Besides, VD 3 at a 1,000 IU/kg diet to 3.5% Ca improved performance of hens fed 3.5% Ca, showing that the potential impact of VD 3 depends on Ca concentrations.

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“…This may have been a high bone index result in deterioration in shell quality [19]. In birds, the role of vitamin D 3 in Ca and P metabolism is crucial, due to its well-documented involvement in bone development and eggshell formation in laying hens [1]. Laying hens, during the later phase of the laying cycle, use Ca from their feed to maintain the hardness of their bones and to participate in the formation of the eggshell strength.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, artificial lighting has been widely used during the full phase of the laying cycle in confined laying hen houses. However, during the later phase of the laying cycle, laying hens in conventional cages are highly susceptible to osteoporosis, due to a calcium deficiency, which is accompanied by a decrease in production performance and egg quality and an increase in mortality [1]. It has been reported that ultraviolet (UV) light exposure could effectively improve the welfare and health of the birds [2][3][4], and be proved to be helpful for osteoporosis symptoms [5,6].…”

Section: Introductionmentioning

confidence: 99%

Effects of B-Wave Ultraviolet Supplementation Using Light-Emitting Diodes on Caged Laying Hens during the Later Phase of the Laying Cycle

Wei

Zheng

et al. 2019

Animals

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Caged laying hens are prone to calcium deficiencies, resulting in osteoporosis and egg quality deterioration during the later phase of the laying cycle. Fluorescent light and light-emitting diodes (LEDs), which are widely used in poultry houses now, are both deficient in ultraviolet (UV) light, the lack of which is detrimental to chickens’ welfare and health. This study was conducted to investigate the effects of UVB light supplementation using LEDs on the bone traits, blood parameters, laying performance, and egg quality for caged laying hens at 68–75 weeks. In total, 120 Jingfen laying hens were randomly assigned to four different groups, with three replicates in each group (10 hens in each cage as a replicate). UVB-LED lamps installed under the feed troughs were used to provide UVB light (296–316 nm) for the birds in the three treatment groups (1 h, 2 h, and 3 h UVB supplementation per day, respectively), while the control group was not exposed to UVB-LED light. Bone traits, egg quality, and amounts of calcium (Ca), phosphorus (P), 25-hydroxyvitamin D3 (25(OH)D3), 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and 7-dehydrocholesterol (7-DHC) in both the serum and egg yolks were tested during the experiment. The results demonstrated that UVB-LED exposure significantly increased the bone mineral density (BMD), egg production, and yolk 1,25(OH)2D3 concentrations (p < 0.05), and reduced the content of serum 7-DHC (p < 0.05), especially in the 2 h/day group; however, it did not improve egg quality, vitamin D metabolites, or photoproducts in the serum and yolk 25(OH)2D3 concentrations (p > 0.05). This study concluded that UVB supplementation using LEDs had a positive effect on caged laying hens during the later phase of the laying cycle.

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Dietary vitamin D3 supplementation protects laying hens against lipopolysaccharide-induced immunological stress

Cited by 40 publications

References 84 publications

Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens

Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens

Calcium and Cholecalciferol Levels in Late-Phase Laying Hens: Effects on Productive Traits, Egg Quality, Blood Biochemistry, and Immune Responses

Effects of B-Wave Ultraviolet Supplementation Using Light-Emitting Diodes on Caged Laying Hens during the Later Phase of the Laying Cycle

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