2020
DOI: 10.1159/000509750
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Dietary Vitamin D Supplementation Is Ineffective in Preventing Murine Cow’s Milk Allergy, Irrespective of the Presence of Nondigestible Oligosaccharides

Abstract: <b><i>Introduction:</i></b> Cow’s milk allergy (CMA) is one of the most common food allergies especially early in life. A mixture of nondigestible short-chain galacto-oligosaccharides, long-chain fructo-oligosaccharides, and pectin-derived acidic-oligosaccharides (GFA) may reduce allergy development and allergic symptoms in murine CMA. Recently, vitamin D (VitD) has been suggested to have beneficial effects in reducing allergy as well. <b><i>Objective:</i></b> In… Show more

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Cited by 3 publications
(3 citation statements)
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References 49 publications
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“…The results revealed no statistically significant differences between the vitamin D-supplemented and placebo groups in the incidence of allergic disease outcomes or allergen sensitization rates at 1 or 2.5 years of age (26). Moreover, the results of an in vivo study demonstrated that high levels of vitamin D did not alleviate allergic symptoms in mice (27,28).…”
Section: Discussionmentioning
confidence: 94%
“…The results revealed no statistically significant differences between the vitamin D-supplemented and placebo groups in the incidence of allergic disease outcomes or allergen sensitization rates at 1 or 2.5 years of age (26). Moreover, the results of an in vivo study demonstrated that high levels of vitamin D did not alleviate allergic symptoms in mice (27,28).…”
Section: Discussionmentioning
confidence: 94%
“…Degranulation of mast cells may cause an anaphylactic shock in severe allergic animals. To assess this anaphylactic shock severity, the animals were monitored closely, using a validated anaphylactic scoring (0, no symptoms; 1, scratching around nose and mouth; 2, swelling around the eyes and mouth, piloerection, reduced activity, higher breathing rate; 3, shortness of breath, blue rash around the mouth and tail, higher breathing rate; 4, no activity after stimulation, shivers, and muscle contractions [ 17 ]). Mice were placed on heating mats when a shock score of 3 was reached with a decrease in body temperature.…”
Section: Methodsmentioning
confidence: 99%
“…challenge. Anaphylactic shock symptoms were scored using a validated, previously described 0- to 4-point scoring system [ 29 ]. The body temperature was monitored at 30 and 60 min, after the i.d.…”
Section: Methodsmentioning
confidence: 99%