Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis

Sun, Yan; Liu, C.; Bo, Yacong; You, Jie; Zhu, Yuanyuan; Duan, Dandan; Han, Chen; Lu, Qingshan

doi:10.1007/s00198-017-4284-9

Cited by 25 publications

(36 citation statements)

References 37 publications

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“…Ascorbic acid is known to stimulate collagen synthesis and secretion (16,27), enhance healing of fractured bones in preclinical studies (30), and significantly decrease the risk of osteoporosis and hip fracture in adults (31,32). Because mice differ from humans and fish by being able to synthesize de novo vitamin C, supplementation did increase bone mass but not in a statistically significant fashion.…”

Section: Discussionmentioning

confidence: 99%

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

Marom¹,

Burrage²,

Clément³

et al. 2020

Preprint

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Coatomer complexes function in the sorting and trafficking of proteins between subcellular organelles. Pathogenic variants in coatomer subunits or associated factors have been reported in multi-systemic disorders, i.e., coatopathies, that can affect the skeletal and central nervous systems. We have identified loss-of-function variants in COPB2, a component of the coatomer complex I (COPI), in individuals presenting with osteoporosis, fractures and developmental delay of variable severity. Because the role of COPB2 in bone has not been characterized, we studied the effect of COPB2 deficiency on skeletal development in mice and zebrafish. Copb2+/− mice showed low bone mass and decreased bone strength. In zebrafish, larvae carrying a copb2 heterozygous frameshift variant showed delayed mineralization. copb2-null embryos showed endoplasmic reticulum (ER) and Golgi disorganization, and embryonic lethality. COPB2 siRNA-treated fibroblasts showed delayed collagen trafficking with retention of type I collagen in the ER and Golgi, and altered distribution of Golgi markers. Our data suggest that COPB2 haploinsufficiency leads to disruption of intracellular collagen trafficking and osteoporosis, which may improve with ascorbic acid supplementation. This work highlights the role of COPI complex as a critical regulator of bone mass and identifies a new form of coatopathy due to COPB2 deficiency.

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Section: Discussionmentioning

confidence: 99%

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

Marom¹,

Burrage²,

Clément³

et al. 2020

Preprint

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“…The 16 studies selected were published between 2006 and 2017 and included 7823 lung cancer patients and 27,2304 control subjects. [ 27 – 42 ] Three studies were conducted in China, [ 27 , 30 , 39 ] 5 studies were conducted in the United States, [ 29 , 35 , 36 , 38 , 42 ] 7 studies were performed in Europe, [ 28 , 31 , 33 , 34 , 37 , 40 , 41 ] and 1 study was conducted in Australia. [ 32 ] Seven studies reported a mean age of <60 years among participants, [ 30 , 34 – 39 ] and 8 studies reported a mean age of >60 years.…”

Section: Resultsmentioning

confidence: 99%

“…[ 32 ] Seven studies reported a mean age of <60 years among participants, [ 30 , 34 – 39 ] and 8 studies reported a mean age of >60 years. [ 27 – 29 , 31 , 32 , 40 , 42 ] Eleven studies were cohort studies, [ 27 , 31 – 33 , 35 , 37 – 39 , 41 , 42 ] and 5 studies were case-control studies. [ 28 – 30 , 36 , 40 ] Five studies included individuals who smoked, [ 30 , 35 , 36 , 41 , 42 ] and 4 studies included non-smokers.…”

Section: Resultsmentioning

confidence: 99%

“…[ 28 – 30 , 36 , 40 ] Five studies included individuals who smoked, [ 30 , 35 , 36 , 41 , 42 ] and 4 studies included non-smokers. [ 29 , 30 , 39 , 41 ] In terms of the pathological type, 5 studies reported on non-small cell lung cancer (NSCLC), [ 27 , 29 , 30 , 41 , 42 ] 3 studies reported on small cell lung cancer (SCLC), [ 27 , 41 , 42 ] 4 studies reported on adenocarcinoma, [ 27 , 29 , 41 , 42 ] and 3 studies reported on squamous carcinoma. [ 27 , 41 , 42 ] In addition, 5 studies investigated the association between the vitamin D level and the risk of lung cancer in women, [ 29 , 37 , 39 – 41 ] and 3 studies evaluated this association in men.…”

Section: Resultsmentioning

confidence: 99%

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Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake

Hu²,

Qian³

et al. 2018

Medicine

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The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945–1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854, 95% CI = 0.741–0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957–0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis.

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“…Deficiency of AA adversely affects fracture healing in elderly AA deficient osteogenic disorder Shionogi rats [17]. Furthermore, AA deficiency is associated with an increased risk of hip fracture [18,19].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Ascorbic Acid Levels in Proximal Femur Fracture Patients Have No Postoperative Clinical Impact, While Ascorbic Acid Levels upon Discharge Have a Major Effect on Postoperative Outcome

Hill-Mündel

Schlegl²,

Biesalski

et al. 2019

JCM

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Proximal femur fractures show a high prevalence in elderly patients and are associated with an elevated risk of multimorbidity and early mortality. Recovery is impaired by malnutrition and oxidative stress, which is affected by antioxidants such as ascorbic acid (AA). This study monitored AA levels during hospitalization of patients with a proximal femur to investigate the influence of AA status to the clinical outcome. AA levels of 25 elderly patients with a proximal femur fracture were measured during hospitalization using high performance liquid chromatography. Plasma samples were collected preoperatively, on the first day after surgery, on the third day after surgery and on the day of discharge. Nutritional Risk Screening 2002 (NRS) and Mini Nutritional Assessment (MNA) were assessed to evaluate the nutritional status. In patients with proximal femoral fractures, preoperative AA concentrations were significantly lower compared to elderly patients without an acute fracture. A significant decrease of 33.8% in AA plasma level was measured on the day after surgery with a significant recovery up to the time of discharge. The preoperative AA status did not have any significant effect on clinical outcome. However, inadequate AA levels (<50 µmol/L) upon discharge significantly increased the incidence and the severity of postoperative complications. These results indicate that the AA status upon discharge has a greater impact on clinical outcome than assumed, and therefore, AA supplementation during hospitalization should be considered.

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Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis

Cited by 25 publications

References 37 publications

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake

Preoperative Ascorbic Acid Levels in Proximal Femur Fracture Patients Have No Postoperative Clinical Impact, While Ascorbic Acid Levels upon Discharge Have a Major Effect on Postoperative Outcome

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