Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice

Zhang, Xueting; Yoshihara, Kazufumi; Miyata, Noriyuki; Hata, Takehisa; Altaisaikhan, Altanzul; Takakura, Satoshi; Asano, Yoki; Izuno, Satoshi; Sudo, Nobuyuki

doi:10.1016/j.physbeh.2021.113653

Cited by 11 publications

(7 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some reports have demonstrated the success of oral glycine supplementation at appropriate doses in reducing toxic liver injury, 26,27 some inflammatory diseases, 28,29 cancer, and cardiovascular disease 30,31 . Aromatic amino acids, including phenylalanine, are essential precursors of monoamine neurotransmitters and play a vital role in many behavioral and emotional functions 32 . In addition to this, many studies have demonstrated that monoamines may act as critical signaling molecules between native bacteria and their intestinal hosts 33,34 .…”

Section: Discussionmentioning

confidence: 99%

“…30,31 Aromatic amino acids, including phenylalanine, are essential precursors of monoamine neurotransmitters and play a vital role in many behavioral and emotional functions. 32 In addition to this, many studies have demonstrated that monoamines may act as critical signaling molecules between native bacteria and their intestinal hosts. 33,34 Several studies have shown that valine supplementation can enhance tRNA aminoacylation by increasing substrate concentrations, improving protein translation, and triggering anticancer effects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unrinsed Nemipterus virgatus surimi provides more nutrients than rinsed surimi and helps recover immunosuppressed mice treated with cyclophosphamide

et al. 2023

View full text Add to dashboard Cite

BACKGROUND The rinsing process in the production of surimi can cause the loss of some important nutrients. To investigate the differences in nutritional properties between rinsed surimi (RS) and unrinsed surimi (US), this study compared the elemental composition, amino acid composition, fatty acid composition, proteomics, and an immunosuppression mouse model of surimi before and after rinsing, and analyzed the nutritional and immunological properties of RS and US. RESULTS The results showed that the protein, fat, and ash contents of RS were decreased compared with those of US; specifically, the contents of essential amino acids, semi‐essential amino acids, non‐essential amino acids, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids were decreased. In the non‐labeled quantitative proteomics analysis, three high‐abundance quantifiable protein contents and 68 low‐abundance quantifiable protein contents were found in RS (P‐values < 0.05, ratio > 2). Immune function experiments in mice revealed that both RS and US contributed to the recovery of immunity in immunocompromised mice. The effect of US was better than that of RS. CONCLUSION The rinsing process in surimi processing leads to the loss of nutrients in surimi. US promotes the recovery of immunity in immunocompromised mice more effectively than RS. © 2023 Society of Chemical Industry.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unrinsed Nemipterus virgatus surimi provides more nutrients than rinsed surimi and helps recover immunosuppressed mice treated with cyclophosphamide

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The excised brains were dissected into the medial prefrontal cortex, striatum, hippocampus, and brain stem. Each sample was prepared as previously described (Nishino et al., 2013; Zhang et al., 2022). Briefly, the samples were homogenized in 0.2 M perchloric acid containing 100 mM disodium EDTA.…”

Section: Methodsmentioning

confidence: 99%

Dietary supplementation with 1‐kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice

Altaisaikhan,

Yoshihara,

Hata

et al. 2023

Physiological Reports

Self Cite

View full text Add to dashboard Cite

Abstract1‐Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological aspects, including behavioral phenotypes and gut microbial ecology. Mice that received KES‐supplemented diets for three generations demonstrated increased activity compared with those fed diets lacking KES. Furthermore, the KES group showed increased striatal dopamine (DA) and serotonin (5‐HT) levels. The observed increase in DA levels within the striatum was positively correlated with locomotor activity in the KES group but not in the control (CON) group. The α‐diversities were significantly lower in the KES group compared to the CON group. The three‐dimensional principal coordinate analysis revealed a substantial distinction between the KES and CON groups across each generation. At the genus level, most gut microbiota genera exhibited lower abundances in the KES group than in the CON group, except for Bifidobacteria and Akkermansia. Spearman's rank‐order analysis indicated significant negative correlations between the striatal DA levels and α‐diversity values. These findings suggest that prolonged supplementation with KES may stimulate increased locomotor activity along with elevated striatal DA levels, which are potentially associated with KES‐induced alterations in the gut microbiota.

show abstract

“…Interestingly, dietary deficiency of Trp can lead to the reduced food intake and body weight in animals, and chronic deficiency of Trp in the diet induces a reduction in monoamines. The downstream metabolites of Trp altered the activity of monoaminergic system, contributing to the increased locomotor activity . In mice, a lack of Trp in the diet leads to the elevated mortality and weakening of nesting behavior. , …”

Section: Intake Status and Safety Of Dietary Trpmentioning

confidence: 99%

“…The downstream metabolites of Trp altered the activity of monoaminergic system, contributing to the increased locomotor activity. 26 In mice, a lack of Trp in the diet leads to the elevated mortality and weakening of nesting behavior. 27,28…”

Section: Intake Status and Safety Of Dietary Trpmentioning

confidence: 99%

Recent Advances in Current Uptake Situation, Metabolic and Nutritional Characteristics, Health, and Safety of Dietary Tryptophan

Zhu,

Yang,

Zhao

2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Tryptophan (Trp) is an essential amino acid which is unable to be synthesized in the body. Main sources of Trp are uptake of foods such as oats and bananas. In this review, we describe the status of current dietary consumption, metabolic pathways and nutritional characteristics of Trp, as well as its ingestion and downstream metabolites for maintaining body health and safety. This review also summarizes the recent advances in Trp metabolism, particularly the 5-HT, KYN, and AhR activation pathways, revealing that its endogenous host metabolites are not only differentially affected in the body but also are closely linked to health. More attention should be paid to targeting its specific metabolic pathways and utilizing food molecules and probiotics for manipulating Trp metabolism. However, the complexity of microbiota−host interactions requires further exploration to precisely refine targets for innovating the gut microbiota-targeted diagnostic approaches and informing subsequent studies and targeted treatments of diseases.

show abstract

Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice

Cited by 11 publications

References 70 publications

Unrinsed Nemipterus virgatus surimi provides more nutrients than rinsed surimi and helps recover immunosuppressed mice treated with cyclophosphamide

Unrinsed Nemipterus virgatus surimi provides more nutrients than rinsed surimi and helps recover immunosuppressed mice treated with cyclophosphamide

Dietary supplementation with 1‐kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice

Recent Advances in Current Uptake Situation, Metabolic and Nutritional Characteristics, Health, and Safety of Dietary Tryptophan

Contact Info

Product

Resources

About