Dietary treatment of progressive feline struvite crystalluria

Gevaert, D.; Smet, Betty De; Wilde, Roland De

doi:10.1111/j.1748-5827.1994.tb03823.x

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…22 However, our observations are similar to other studies 13,[39][40][41] in which struvite crystalluria was observed in cats fed low-magnesium, urine-acidifying foods. When present, struvite was the predominant crystal type observed in urine sediment from both cats fed prevention food and cats fed control food; calcium oxalate crystalluria was not observed in cats of either food group.…”

Section: Discussionsupporting

confidence: 92%

Comparison of foods with differing nutritional profiles for long-term management of acute nonobstructive idiopathic cystitis in cats

Kruger¹,

Lulich²,

MacLeay³

et al. 2015

javma

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Section: Discussionsupporting

confidence: 92%

Comparison of foods with differing nutritional profiles for long-term management of acute nonobstructive idiopathic cystitis in cats

Kruger¹,

Lulich²,

MacLeay³

et al. 2015

javma

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“…Moist foods are known to reduce urine concentration of urolith-forming metabolites. 6 The observed reversal of the effect of moisture content of diet is unclear. Possibly, dry diets could be a predisposing factor for HSC up to a stage in life.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, nearly 30% of cats with struvite crystalluria experience hematuria due to the irritation of the bladder walls by the crystals. 6 Therefore, an evaluation of the presence of struvite crystals in the urine of cats with hematuria could provide useful information in our understanding of these common condition in cats.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with hematuric struvite crystalluria in cats

Okafor

Pearl²,

Blois³

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives The aim of the study was to identify any dietary, signalment, geographic and clinical factors associated with hematuric struvite crystalluria (HSC) in a population of cats that visit general care veterinary hospitals in the USA. Methods In total, 4032 cats that had a first-time diagnosis of HSC and 8064 control cats with no history of hematuria or crystalluria were identified from medical records of all cats examined between 2007 and 2011 at 790 US veterinary hospitals. Extracted variables included age, sex, neuter status, breed, diet, urinalysis results and history of cystitis. Potential associations between these variables and HSC were estimated. Results Controlling for other factors, young cats fed a dry diet had an increased likelihood of HSC relative to young cats fed a non-dry diet. However, as age increased, the likelihood of HSC declined for cats fed a dry diet and increased for cats fed a non-dry diet. Moreover, the odds of HSC were significantly greater when cats were unneutered (vs neutered; odds ratio [OR] 45.52) or had a thin (vs heavy) body condition (OR 23.81), diagnosis of cystitis (OR 2.84), urine protein concentration >30 mg/dl (OR 4.72), alkaline (vs neutral) urine pH (OR 3.34), pyuria (OR 23.67) or bacteriuria (OR 2.24). Conclusions and relevance The present study provides estimates of the strengths of association between HSC and certain signalment and clinical characteristics of cats. This information could help clinicians to perform a more directed screening for struvite crystalluria in certain cat populations. Follow-up studies that build on the findings of this study could explore the clinical importance of HSC in cats.

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“…Gevaert et al proposed that large numbers of crystals could be irritating to the bladder wall, after inducing marked struvite crystalluria in eight healthy cats by feeding them a commercial dry cat food and observing haematuria, proteinuria and weight loss in two of the treated cats; both the crystalluria and clinical signs in these cats resolved with feeding of a calculolytic diet. 24 In an experimental rodent model, induction of heavy crystalluria in rats was associated with hyperreflexiveness of the micturition reflex, a result that investigators hypothesised was an effect of crystals on the bladder mucosa. 25 In human medicine, administration of the anti-retroviral drug indinavir can induce a marked crystalluria that has been associated with back pain, with and without urolithiasis.…”

Section: Discussionmentioning

confidence: 99%