Dietary Treatment for NAFLD: New Clinical and Epidemiological Evidence and Updated Recommendations

Zelber‐Sagi, Shira

doi:10.1055/s-0041-1729971

Cited by 11 publications

(9 citation statements)

References 124 publications

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“…Finally, a similar non-linear response was found for hepatocellular carcinoma, with a decreased risk for subjects who drank at least two coffees/day (or decaffeinated coffees) [209] .…”

Section: Coffee Seems Protective For Mafldsupporting

confidence: 56%

What should we advise MAFLD patients to eat and drink?

Machado¹

2021

MTOD

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“…Finally, a similar non-linear response was found for hepatocellular carcinoma, with a decreased risk for subjects who drank at least two coffees/day (or decaffeinated coffees) [209] .…”

Section: Coffee Seems Protective For Mafldsupporting

confidence: 56%

What should we advise MAFLD patients to eat and drink?

Machado¹

2021

MTOD

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“…If the Mediterranean diet (Med-diet), featuring homemade, unprocessed plant-based foods as well as fish and poultry in low to moderate amounts, is deemed to protect from NAFLD and NASH, the growing global consumption of ultra-processed hypercaloric foods enriched in simple sugars and hydrogenated fats is deemed to facilitate the metabolic syndrome, steatosis, and its histological progression [ 85 ] . These notions have tremendous clinical potential in as much as they indicate what NAFLD/NASH/MAFLD patients should be suggested to eat [ 86 ] .…”

Section: Nafld Cofactorsmentioning

confidence: 99%

Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction

Lonardo¹,

Singal²,

Osna³

et al. 2022

Metab Target Organ Damage

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Primary nonalcoholic fatty liver disease (NAFLD) is bi-directionally associated with the metabolic syndrome and its constitutive features (“factors”: impaired glucose disposal, visceral obesity, arterial hypertension, and dyslipidemia). Secondary NAFLD occurs due to endocrinologic disturbances or other cofactors. This nosography tends to be outdated by the novel definition of metabolic associated fatty liver disease (MAFLD). Irrespective of nomenclature, this condition exhibits a remarkable pathogenic heterogeneity with unpredictable clinical outcomes which are heavily influenced by liver histology changes. Genetics and epigenetics, lifestyle habits [including diet and physical (in)activity] and immunity/infection appear to be major cofactors that modulate NAFLD/MAFLD outcomes, including organ dysfunction owing to liver cirrhosis and hepatocellular carcinoma, type 2 diabetes, chronic kidney disease, heart failure, and sarcopenia. The identification of cofactors for organ dysfunction that may help understand disease heterogeneity and reliably support inherently personalized medicine approaches is a research priority, thus paving the way for innovative treatment strategies.

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“…In addition, fiber, coffee, green tea, and olive oil could be also protective factors for NAFLD development and progression. 6 Thus, we should encourage patients to increase intake of beneficial foods and avoid these dangerous foods ( Table 1 ).…”

Section: Dietary Recommendations For the Management Of Nafldmentioning

confidence: 99%

Dietary Recommendations for the Management of Non-alcoholic Fatty Liver Disease (NAFLD): A Nutritional Geometry Perspective

2022

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Diet could be both culprit and solution of NAFLD. Dietary modifications have been associated with histological features improvement in NAFLD. The Western diet was related to a greater risk of disease progression while the Mediterranean diet (MD) could promote regression of histological lesions. Modifications in the nutrient composition seems to have lesser impact on NAFLD than dietary modifications. An intrinsic interaction between nutrients in the diet support a specific effect not seen when added separately. Dietary modifications should focus on promoting weight loss but also look for patterns that are able to promote histological improvement. Although several micronutrients' deficit has been related to NAFLD progression, prescribing these micronutrients' supplementation did not reach a positive impact. However, an enriching diet with specific nutrients could be useful, like olive oil supplemented in MD. Geometry of nutrition defines a framework to better understand the interaction between nutrients, foods, and dietetic pattern in the model of diseases and how we could approach taking into consideration the interaction between meals and disease features. After analyzing baseline diet and histological lesions, we could calculate the distance to optimal diet and to promote changes in lifestyle to reach all these goals. A standard MD menu would be recommended.

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Dietary Treatment for NAFLD: New Clinical and Epidemiological Evidence and Updated Recommendations

Cited by 11 publications

References 124 publications

What should we advise MAFLD patients to eat and drink?

What should we advise MAFLD patients to eat and drink?

Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction

Dietary Recommendations for the Management of Non-alcoholic Fatty Liver Disease (NAFLD): A Nutritional Geometry Perspective

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