Dietary Tannins and Salivary Proline-Rich Proteins: Interactions, Induction, and Defense Mechanisms

Mehansho, Haile; Butler, Larry G.; Carlson, Don M.

doi:10.1146/annurev.nu.07.070187.002231

Cited by 329 publications

(172 citation statements)

References 37 publications

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“…In addition, acorns provide high amounts of crude fibres (including lignin, above all), resulting in reduced digestibility rate of organic matter and lower expected metabolizable energy of the diet. Feed intake depression from acorns tannins in the diet can be excluded and this finding is in contrast with references [45][46][47][48][49][50][51] Table 2 reports tannins intakes recorded throughout the experimental feeding (one week) for the three groups of animals according to acorns inclusion in the diet (70% vs 50% vs 0%) and entity of parotidomegaly, expressed as percentage of mass increase (70% and 50% acorns combined diets groups) compared to the parotid gland from the control diet (0% acorns combined diets).…”

Section: Daily Feed Intakes and Dietary Tannins Ingestion From Differmentioning

confidence: 62%

“…As reported in literature, common characteristics of proteins and polypeptides with high affinity for tannins are their open loose structure, a high proline content and small size [46,52,53]. The capability of some animal species to counteract high dietary tannins was seen to be linked to salivary proline rich proteins (PRPs) ancestral function in the maintenance of oral health at a basal level of mucoproteins secretion, increased by high tannins presence in the diet [54], as observed in pigs [55], in which an increase up to a 16.8% of proline/crude protein ratio of parotid glands chemical composition was seen (Figure 1) after the inclusion of a 70% of acorns in the diet, providing high amounts of hydrolizable tannins (36.1 g TAE·kg -1 DM, expressed as tannic acid equivalents).…”

Section: Salivary Tannins Binding Proteins: the Role Of Proline Rich mentioning

confidence: 87%

“…Scientific references report evident correlation between dietary polyphenols rich diets and health enhancing properties: antioxidant properties [11][12][13], antibacterial activity on different bacterial strains in vitro and in vivo [7,[14][15][16][17][18][19][20], antiparasitic [21], antiulcerogenic [22][23][24] antidiarrhoic [25], antimutagenic [26][27][28][29][30][31][32][33], antitumor [34][35][36][37][38], and some neoplastic cell line apoptosis [39,40]. On the other hand, high tannins diets might also result in detrimental effects like hepatotoxicity [41,42], toxic nephrosis [43], oesphageal cancer [44], depression of feed intake and growth rate in many animal species [45][46][47][48][49][50][51].…”

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

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Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns' tannins content in the diet was positively correlated (R 2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg -1 body weight·d -1 respectively, after one week exposure.

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Section: Daily Feed Intakes and Dietary Tannins Ingestion From Differmentioning

confidence: 62%

Section: Salivary Tannins Binding Proteins: the Role Of Proline Rich mentioning

confidence: 87%

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

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Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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“…It has been suggested that the main function of basic PRPs is to bind ingested plant polyphenols (tannins) [3]. Tannins have a range of harmful effects including the inhibition of digestive enzymes [4], and their complexation with salivary PRPs causes them to be precipitated and excreted in a harmless form.…”

Section: Introductionmentioning

confidence: 99%

Tannin interactions with a full‐length human salivary proline‐rich protein display a stronger affinity than with single proline‐rich repeats

et al. 1996

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“…PRP bind polyphenols and protect rats against the toxic effects of polyphenols [4]. The induction of salivary PRP can be mimicked by treatment of rodents with the P-adrenergic agonist isoprenaline [2, 31.…”

mentioning

confidence: 99%

cDNA clones for mouse parotid proline‐rich proteins

Layfield

Bannister

Pierce

et al. 1992

European Journal of Biochemistry

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cDNA clones for mRNA sequences regulated by isoprenaline in mouse parotid glands were identified by differential colony hybridisation and all hybridised to a diagnostic proline-rich protein (PRP) oligonucleotide. They were divided into two cross-hybridisation groups, A and B, which were shown by hybrid-selected translations to encode acidic PRP and basic PRP, respectively.The A-type subgroup consisted of sequences homologous to the previously identified mouse PRP genes MP2 and MP3. The B-type subgroup comprised clones for the previously identified cDNA pUMP125 (MP4) as well as other PRP sequences. Six of the B-type clones contained a novel PRP cDNA (MPS) and these were sequenced. The composite MP5 cDNA was 897 nucleotides long and contained an open reading frame capable of encoding a 260-residue-long salivary PRP precursor (30% Pro, 19% Gln and 18% Gly), containing nine variant repeat units of consensus PGNQQGP-PPQGGPQQ(GPP)R(PPQ). MP5 was 80% identical to the sequence of MP4 and had a high degree of similarity (60%) at its 3'-untranslated region to rat salivary glutamate/glutamine-rich protein (GRP) cDNA. Two MP5 clones contained a 273-bp intron-like insertion in the 3' untranslated region, being derived, therefore, from incompletely spliced MP5 transcripts.Northern blotting showed that, although PRP mRNA species were induced by isoprenaline, a B-type PRP mRNA was present in normal parotid glands. RNA dot-blots probed with PRP-genespecific oligonucleotides established that MP3, MP4 and MP5 PRP mRNA were all induced by isoprenaline.Multiple salivary proline-rich proteins (PRP) [l] are induced by dietary plant polyphenols in rats and mice [2, 31. PRP bind polyphenols and protect rats against the toxic effects of polyphenols [4]. The induction of salivary PRP can be mimicked by treatment of rodents with the P-adrenergic agonist isoprenaline [2, 31.The multiple PRP species are encoded by a multigene family and in humans both differential RNA splicing and proteolytic cleavages generate more than 20 PRP from only six genes [5].In mice, induction of PRP by isoprenaline is due, at least in part, to increased transcription of PRP genes in parotid acinar cells [6]. Isoprenaline activates P-adrenoceptors and indirect evidence suggests that CAMP is the intracellular messenger [7], although the precise details of how induction occurs are still undetermined.Evidence from in vitro translations shows that in Balb/C mice there are six PRP mRNA species which are induced by isoprenaline, two of which encode acidic or A-type PRP and four of which encode basic or B-type PRP [8]. There are also at least two distinct constitutive PRP [9].

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Dietary Tannins and Salivary Proline-Rich Proteins: Interactions, Induction, and Defense Mechanisms

Cited by 329 publications

References 37 publications

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Tannin interactions with a full‐length human salivary proline‐rich protein display a stronger affinity than with single proline‐rich repeats

cDNA clones for mouse parotid proline‐rich proteins

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