Dietary Supplements in Cancer Prevention and Therapy

Picciano, Mary Frances; Cohen, Barbara; Thomas, Paul R.

doi:10.1016/b978-012088393-6/50084-1

Cited by 1 publication

(1 citation statement)

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“…The gains made in in vitro investigations and the use of animal models for in vivo experimentation on the mechanisms of action of various phytochemicals and their bioavailability provide the foundation for pre-clinical and clinical trials. The paradigm of a rigorous systematic research approach to access the health benefits of nutraceuticals and their recommendation has been proposed by Dr. Mary Frances Picciano and colleagues (Table 1.2) (Picciano et al 2006). The paradigm begins with preclinical in vitro and in vivo studies and epidemiological evidence, before human clinical trials are conducted.…”

Section: Current Research and Future Directionsmentioning

confidence: 99%

Global Overview of the Role of Nutraceuticals in Cancer

Harris

Srihari

2011

Nutraceuticals and Cancer

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Cancer is a chronic disease of the genome that is influenced by nutritional factors at many stages of carcinogenesis, promotion and progression. A number of studies have demonstrated that dietary factors affect cancer risk. Previously these investigations have focused on macro-and micronutrients but more recent studies have explored the actions of non-nutritional phytochemicals and nutraceuticals. Investigations of the mechanisms of action of phytonutrients have led to pre-clinical studies with promising results. In the post-genomic era, the application of "omic" technologies provides further advances in nutraceutical research by utilizing integrative systems biology. In the future, well-designed clinical trials will help elucidate the role of nutraceuticals in the therapy and prevention of cancer and the role of complementary and alternative medicine (CAM) therapies in cancer management. Abbreviations AICR

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Section: Current Research and Future Directionsmentioning

confidence: 99%