Dietary Supplements in a National Survey: Prevalence of Use and Reports of Adverse Events

Timbo, Babgaleh; Ross, M; McCarthy, Patrick V.; Lin, Chung-Tung Jordan

doi:10.1016/j.jada.2006.09.002

Cited by 270 publications

(211 citation statements)

References 17 publications

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“…Quite surprisingly a strong association was observed when Fok I polymorphism was stratified with dwelling (subjects with a frequency distribution of 77.27% and homozygous for F allele and subjects with a frequency of 70.37% and heterozygous for F genotype belonged to rural areas); and Fok I polymorphism was stratified with rural colon cancer subjects (FF, 80% and Ff, 83.3%) possible reasons for such an observation may be, deficiency of micronutrients like folate, Vitamin B6, Vitamin B12 and methionine that have been reported to protect against cancer by preventing against abberrant DNA methylation patterns that are commonly seen in colorectal tumors (Feinberg et al, 1987;Kovacic et al, 2001;Borek et al, 2004;Timbo et al, 2006). Deficiency of these micronutrients remains high among under-privileged rural class, moreover they are relatively high consumers of tobacco (in the form of Hukka), beef, sun dried vegetables and salted tea (both very rich source of carcinogens), all of these factors predominating among the rural back ward classes of Kashmir, have been suggested to have a strong role to play in the etiology of cancers (Chakravarti et al, 1975;Siddiqi et al, 1988;Dar et al, 2012;.…”

Section: Discussionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir

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Section: Discussionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The clinical benefit, compliance, efficacy of this program would comprise an elaborate report. These have been published clinical observations and benefits under various indications [1][2][3][4][90][91][92]. The clinical observations are reported here.…”

Section: The Concept Of Low Dose Once In Three Days Cyclical Nutritiomentioning

confidence: 72%

“…Or by strengthening the hair roots with the right choice of antioxidants, minerals, vitamins, and amino acids and promoting hair growth. However, excess use of antioxidants, vitamin A, vitamin E, omega 3 can cause hair loss instead of hair growth [1][2][3][4]. Hair growth achieved through a combination of nutrients delivers wellness, good health and hair growth without the possibility of side effects from the use of hair loss medications.…”

Section: Introductionmentioning

confidence: 99%

The Concept of Cyclical Nutritional Therapy for Hair Growth which can be Applied for Wellness

Rajput¹

2017

J Nutr Food Sci

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Hair growth can be achieved by fighting hair loss with medications or by strengthening the hair roots with nutrients. Caution as excess vitamin A, vitamin E, omega 3 cause hair loss instead of hair growth. Supplements are considered harmless and consumed without thinking of interactions or overdose. Therapeutic doses of vitamins to treat disease are high, however preventive or prophylactic dose for wellness are low. Antioxidants improve health by neutralizing Reactive oxygen species, but ROS have important role in infection control and phagocytosis. Overuse of antioxidants interferes with protective mechanisms. High doses of one nutrient affect the absorption and efficiency of others. Administered together, vitamin C can destroy vitamin B12. Iron and calcium reduce the absorption of one another. High vitamin C, increases sodium & reduces potassium levels. Nutrients are also synergistic. Vitamin E regenerates Beta carotene. Vitamin C regenerates vitamin E. Toxic effects of Beta carotene break down products are reduced by alpha tocopherol, N acetyl cysteine and vitamin C. Single deficiency causes multiple inefficiencies. Inappropriate combinations and nutrient overdose are easily possible with rising use of multivitamins and fortified foods. Nutrient deficiencies are compensated by autophagy and also prevail as subclinical deficiencies making them difficult to detect on laboratory tests. To utilize nutrients without interaction and overdose we have proposed the use of different synergistic nutrients on different days of the week, repeating in a three day cycle. The concept was initiated for achieving consistent hair growth as published earlier. It can be applied to a set of nutrients identified for various other indications like geriatrics, pediatrics, growing teens, athletes, body builders, women's health, cardiac patients, diabetics, athletes, bariatric surgery etc. ensuring low dose, low cost, and optimum benefit nutrient program allowing the body to assimilate and utilize each nutrient, without wastage or overdose.

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“…Correct Answers: B and E Amoxicillin-clavulanate is the most frequent cause of idiosyncratic DILI in several European and American series. [64][65][66][67] The incidence of DILI is much higher with the amoxicillin-clavulanic acid combination than with amoxicillin alone. 68,69 The risk increases with age, and males are at a slightly greater risk.…”

Section: Correct Answers: a D And Ementioning

confidence: 99%

Hepatobiliary Quiz (Answers)—16 (2015)

Rathi

Dhiman

2015

Journal of Clinical and Experimental Hepatology

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Dietary Supplements in a National Survey: Prevalence of Use and Reports of Adverse Events

Cited by 270 publications

References 17 publications

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

The Concept of Cyclical Nutritional Therapy for Hair Growth which can be Applied for Wellness

Hepatobiliary Quiz (Answers)—16 (2015)

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