Dietary supplements and fatigue in patients with breast cancer: a systematic review

Pereira, Paula Tâmara Vieira Teixeira; Reis, Andréa Dias; Diniz, Renata Rodrigues; Lima, Franciléia Andrade; Leite, Richard Diego; Silva, Mayara da; Guerra, Rosane Nassar Meireles; Moraes, Érica Brandão de; Garcia, João Batista Santos

doi:10.1007/s10549-018-4857-0

Cited by 23 publications

(23 citation statements)

References 24 publications

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“…Despite the large theoretical rationale from animal and in vitro models for therapeutic use of anti-inflammatory diets in fatigued patients, and also some interesting and promising results from human trials, the evidence in humans is rare. Most of all, systematic reviews, which investigated the effects of different nutritional interventions on idiopathic fatigue as well as disease-related fatigue, share this conclusion [41,53,85,94,110], with the exception of studies in patients with cancer [14,86] or SLE [63].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, current investigations show that there are new techniques available (including nanoparticles) that make it possible to apply higher vitamin doses to treat fatigue without negatively affecting chemotherapy [144]. Nonetheless, adverse side effects are more often described in administration of high-dose single nutrients than in the context of a combined therapy or whole diet [86].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a meta-analysis including 12 trials concluded that fatigue cannot be treated effectively with L-carnitine supplementation in patients with cancer [85]. Moreover, adverse events have to be taken into account when administering high doses of L-carnitine [86].…”

Section: Anti-inflammatory Dietary Strategiesmentioning

confidence: 99%

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Anti-Inflammatory Diets and Fatigue

2019

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Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals’ use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory Diets and Fatigue

2019

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“…The goal of maintaining a normal weight through a diet is a factor of good prognosis [35], whereas weight gain after the diagnosis of breast cancer is associated with a higher mortality rate, further increased in case of a weight gain of 10% or more [37]. If food supplements are debated in the literature [38], patients have a particular interest in them based on the frequency of citation.…”

Section: Discussionmentioning

confidence: 99%

Complementary and Alternative Medicine in Patients With Breast Cancer: Exploratory Study of Social Network Forum Data

Lognos¹,

Carbonnel²,

Launay³

et al. 2019

JMIR Cancer

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BackgroundPatients and health care professionals are becoming increasingly preoccupied in complementary and alternative medicine (CAM) that can also be called nonpharmacological interventions (NPIs). In just a few years, this supportive care has gone from solutions aimed at improving the quality of life to solutions intended to reduce symptoms, supplement oncological treatments, and prevent recurrences. Digital social networks are a major vector for disseminating these practices that are not always disclosed to doctors by patients. An exploration of the content of exchanges on social networks by patients suffering from breast cancer can help to better identify the extent and diversity of these practices.ObjectiveThis study aimed to explore the interest of patients with breast cancer in CAM from posts published in health forums and French-language social media groups.MethodsThe retrospective study was based on a French database of 2 forums and 4 Facebook groups between June 3, 2006, and November 17, 2015. The extracted, anonymized, and compiled data (264,249 posts) were analyzed according to the occurrences associated with the NPI categories and NPI subcategories, their synonyms, and their related terms.ResultsThe results showed that patients with breast cancer use mainly physical (37.6%) and nutritional (31.3%) interventions. Herbal medicine is a subcategory that was cited frequently. However, the patients did not mention digital interventions.ConclusionsThis exploratory study of the main French forums and discussion groups indicates a significant interest in CAM during and after treatments for breast cancer, with primarily physical and nutritional interventions complementing approved treatments. This study highlights the importance of accurate information (vs fake medicine), prescription and monitoring of these interventions, and the mediating role that health professionals must play in this regard.

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“…The effect of these PUFA is more varied. While Holmes et al [56] showed no relation between fish consumption and breast cancer, recent studies confirmed the positive impact of n-3 fat on not only inhibiting [67,68], but also reducing fatigue [69], in breast cancer patients. In contrast to the large number of studies that confirmed the positive effects of n-3 PUFA on these two major chronic diseases, other research findings reported neutral, inconclusive or even possible negative effects [62].…”

Section: Metabolic Pathways Human Health Benefits and Recommendedmentioning

confidence: 99%

Enhancing Omega-3 Long-Chain Polyunsaturated Fatty Acid Content of Dairy-Derived Foods for Human Consumption

et al. 2019

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Omega-3 polyunsaturated fatty acids (n-3 PUFA) are termed essential fatty acids because they cannot be synthesized de novo by humans due to the lack of delta-12 and delta-15 desaturase enzymes and must therefore be acquired from the diet. n-3 PUFA include α-linolenic acid (ALA, 18:3n-3), eicosapentaenoic (EPA, 20:5n-3), docosahexaenoic (DHA, 22:6n-3), and the less recognized docosapentaenoic acid (DPA, 22:5n-3). The three long-chain (≥C20) n-3 PUFA (n-3 LC-PUFA), EPA, DHA, and DPA play an important role in human health by reducing the risk of chronic diseases. Up to the present time, seafood, and in particular, fish oil-derived products, have been the richest sources of n-3 LC-PUFA. The human diet generally contains insufficient amounts of these essential FA due largely to the low consumption of seafood. This issue provides opportunities to enrich the content of n-3 PUFA in other common food groups. Milk and milk products have traditionally been a major component of human diets, but are also among some of the poorest sources of n-3 PUFA. Consideration of the high consumption of milk and its processed products worldwide and the human health benefits has led to a large number of studies targeting the enhancement of n-3 PUFA content in dairy products. The main objective of this review was to evaluate the major strategies that have been employed to enhance n-3 PUFA content in dairy products and to unravel potential knowledge gaps for further research on this topic. Nutritional manipulation to date has been the main approach for altering milk fatty acids (FA) in ruminants. However, the main challenge is ruminal biohydrogenation in which dietary PUFA are hydrogenated into monounsaturated FA and/or ultimately, saturated FA, due to rumen microbial activities. The inclusion of oil seed and vegetable oil in dairy animal diets significantly elevates ALA content, while the addition of rumen-protected marine-derived supplements is the most effective way to increase the concentration of EPA, DHA, and DPA in dairy products. In our view, the mechanisms of n-3 LC-PUFA biosynthesis pathway from ALA and the biohydrogenation of individual n-3 LC-PUFA in ruminants need to be better elucidated. Identified knowledge gaps regarding the activities of candidate genes regulating the concentrations of n-3 PUFA and the responses of ruminants to specific lipid supplementation regimes are also critical to a greater understanding of nutrition-genetics interactions driving lipid metabolism.

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Dietary supplements and fatigue in patients with breast cancer: a systematic review

Cited by 23 publications

References 24 publications

Anti-Inflammatory Diets and Fatigue

Anti-Inflammatory Diets and Fatigue

Complementary and Alternative Medicine in Patients With Breast Cancer: Exploratory Study of Social Network Forum Data

Enhancing Omega-3 Long-Chain Polyunsaturated Fatty Acid Content of Dairy-Derived Foods for Human Consumption

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