Dietary supplementation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid beta-injected rats

Dietary supplementation with Salvia sahendica attenuates acetylcholinesterase activity and increases mitochondrial transcription factor A and antioxidant proteins in the hippocampus of amyloid beta-injected rats

“…In this study, S. sahendica consumption in male rats proved as a protective subject by decreasing AChE activity and oxidative injury in response to intrahippocampal injection of Aβ along with increasing pro‐survival factors. These results illustrated some pathways involved in memory deficit improvement and the anti‐apoptotic function of S. sahendica extract in Aβ‐injected rats that was reported previously …”

“…Due to AChE inhibition, neurotransmitters have much more time to influence synapses and better transmission of signals. It seems that having this capacity is one of the main reasons for learning and memory improvement in Aβ‐injected rats fed with S. sahendica …”

“…Our previous study indicated that S. sahendica alleviates the cognitive dysfunction caused by amyloid beta 1–42 (Aβ) injection into the hippocampus of rats. Moreover, it protects against Aβ‐mediated neuronal apoptosis and cell damage . Nevertheless, the underlying mechanism has not been clearly established.…”

Mori Fructus improves cognitive and neuronal dysfunction induced by beta-amyloid toxicity through the GSK-3β pathway in vitro and in vivo

“…Therefore, several clinical and experimental studies focused on the beneficial role of herbal medicines or functional foods in cellular signaling in AD (Khodagholi and Ashabi, 2012;Kim and Oh, 2012;Miller and Shukitt-Hale, 2012).…”

Effect of Salvia sahendica Extracts on Neuromuscular Transmission in Chick Biventer Cervicis Muscle

“…7 A behavioral and biochemical study has showed that treatment with S. sahendica can protect rats against apoptosis and memory impairment induced by the  amiloide injection. 8 Shaerzadeh et al 9 indicated that S. sahendica prevents harmful effects of reactive oxygen species by stabilizing mitochondrial membranes and inhibiting ER…”