Dietary supplementation with PUFAs rescues the eggshell defects caused byseipinmutations inC. elegans

Abstract

22SEIPIN, an ER membrane protein, plays critical roles in lipid droplet (LD) formation and lipid 23 storage. Dysfunction of SEIPIN causes a variety of human diseases, including lipodystrophy, 24 neuropathies, and male and female infertility. However, the cellular and molecular mechanisms 25 of SEIPIN in causing these diseases are poorly understood. To address such mechanisms, we 26 investigated the functional roles of R01B10.6 (seip-1), the sole SEIPIN1 ortholog in C. elegans, 27