Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Modulate Matrix Metalloproteinase Immunoreactivity in a Mouse Model of Pre-abdominal Aortic Aneurysm

Investigation of long chain omega‐3 PUFAs on arterial blood pressure, vascular reactivity and survival in angiotensin II‐infused Apolipoprotein E‐knockout mice

“…This finding suggests a localised benefit of LC n‐3 PUFAs to the abdominal aorta. The authors have recently reported that a high LC n‐3 PUFA diet protects against inflammatory cell infiltration and production of reactive oxygen species and matrix metalloproteinase in the abdominal aorta of angiotensin II‐infused ApoE −/− mice …”

“…The authors have recently reported that a high LC n-3 PUFA diet protects against inflammatory cell infiltration and production of reactive oxygen species and matrix metalloproteinase in the abdominal aorta of angiotensin II-infused ApoE À/À mice. 14,15 Increases in mean arterial pressure in angiotensin II-infused ApoE À/À mice have recently been reported. 5 In the present study, no significant difference was observed in the change in SBP or DBP after 10 days of angiotensin II infusion for mice that were fed a high or low n-3 PUFA diet.…”

“…13 It has been shown recently that angiotensin II-infused ApoE À/À mice fed a high LC n-3 PUFA diet showed no evidence of aortic dissection, reduced numbers of infiltrating neutrophils and macrophages, reduced oxidative stress, and an improved profile of MMP-9 to tissue inhibitor of matrix metalloproteinase (TIMP-1) when compared to angiotensin IIinfused ApoE À/À mice fed a low LC n-3 PUFA diet. 14,15 Further, increased levels of the pro-resolving DHA metabolite resolvin D1, were observed in angiotensin II-infused ApoE À/À mice fed the high compared to the low LC n-3 PUFA diet, indicating conversion of DHA to resolvin D1 during the acute inflammatory challenge. 14 However, the effects of LC n-3 PUFAs on blood pressure and vascular reactivity in an ApoE À/À mouse model of AAA have so far not been examined.…”

Abdominal aortic aneurysm and omega-3 polyunsaturated fatty acids: Mechanisms, animal models, and potential treatment

“…A number of studies have used animal models to investigate the effect of LC n-3 PUFAs or their metabolites on either early or late stages of AAA development (Table 1). These studies infused ApoE -/mice with angiotensin II for 2-14 days to induce a pre-AAA inflammatory response [85,94,95] or for 4 weeks to induce AAA [96]. In one study, short-term CaCl 2 application to the periaortic region followed by 6 week maintenance of the animals facilitated AAA development [97], while another study perfused the abdominal aorta with elastase for 5 min, followed by maintenance of animals for 2 weeks [86].…”

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

“…Relief of pain and inflammation (Chan, K. et al, 2000) High dose and low dose of Omega-3 from purslane for eight-week Anti-inflammatory cell effect on modulation of TIMPs, TGFs, and MMPs in vivo in mice model Higher TIMP-1 and TGF-beta1 stain intensity in mice fed the high, compared to the low Omega-3 diet. MMP-2 immunoreactivity was unaffected by diet (Kavazos, K. et al, 2015) An aqueous extract of purslane leaves and stems Prevention of TNF-alpha-induced vascular inflammatory process in the human umbilical vein endothelial cell (HUVEC)…”