Dietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitis

Cosme‐Silva, Leopoldo; Dal‐Fabbro, Renan; Cintra, Luciano Tavares Ângelo; Ervolino, Edílson; Prado, Alana Sant'Ana do; Oliveira, Daniel Pinto de; Marcelos, Priscylla Gonçalves Correia Leite de; Gomes‐Filho, João Eduardo

doi:10.1590/1678-7757-2020-0483

Cited by 7 publications

(17 citation statements)

References 32 publications

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“…animalis subs. lactis and Streptococcus thermofilus ) also reduced inflammation and bone resorption in apical periodontitis 27 . L .…”

Section: Discussionmentioning

confidence: 89%

“…lactis and Streptococcus thermofilus) also reduced inflammation and bone resorption in apical periodontitis. 27 L. acidophilus and Bifidobacterium inhibit the growth of periodontopathogens like P. gingivalis 28 and significantly reduced gingival inflammation and plaque accumulation in school children. 29 A combination of lactobacillus strains (L. reuteri, salivarius and acidophilus) demonstrated significant reduction in pocket, bleeding on probing and attachment gain in severe periodontitis patients.…”

Section: Ta B L Ementioning

confidence: 95%

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Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial

Ambili

Nazimudeen

Baiju

2022

Int J Dental Hygiene

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Objectives Dysbiosis of oral microbiome play an integral role in periodontitis. Bacterial balance is an important aspect of host defence. Mechanical debridement alone is insufficient to manage many cases. Probiotics are a novel adjunctive strategy, but the beneficial effects of probiotics in the management of moderate periodontitis have not been evaluated before. The objective of the present study was to assess the efficacy of probiotic mouth rinse of Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium longum and Saccharomyces boulardii as an adjunct to mechanical debridement in grade II periodontitis. The study also evaluated change in salivary pH and IgA in both groups. Methods The study was registered under Clinical Trial Registry of India (CTRI NO: CTRI/2019/10/021630). 60 patients with stage II periodontitis were randomized into probiotic and placebo group (n = 30 in each group) after mechanical debridement. Patients were instructed to use mouth rinse twice a day for 30 days. Periodontal parameters (Plaque index, Gingival index, Pocket depth and clinical attachment level) were recorded at baseline, after 1 and 3 months. Salivary pH was tested using a pH metre and IgA using enzyme linked immunosorbent assay. Results Significant improvement in all clinical parameters were noted in both the groups after 1 and 3 months. Intergroup comparison revealed significant difference in gingival index, probing depth and clinical attachment gain. Significant elevation of salivary IgA and pH was noticed in probiotic group in contrast to placebo group. Conclusion The present study supports the use of probiotic mouthwash as an adjunct to mechanical therapy for the management of stage II periodontitis.

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“…animalis subs. lactis and Streptococcus thermofilus ) also reduced inflammation and bone resorption in apical periodontitis 27 . L .…”

Section: Discussionmentioning

confidence: 89%

Section: Ta B L Ementioning

confidence: 95%

Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial

Ambili

Nazimudeen

Baiju

2022

Int J Dental Hygiene

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“…One publication tested the GNC Probiotic Complex CODE424639 constituted by Lactobacillus acidophilus , Lactobacillus salivaris , Lactobacillus plantarum , Lactobacillus rhamnosus , Bifidobacterium bifidum , Bifidobacterium animalis subs. lactis and Streptococcus thermofilus [28].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of probiotics in apical periodontitis progression: A scoping review and implications for research

Rosa¹,

Pedullà²

2022

Aust Endodontic J

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To synthesise the current knowledge on the effects of probiotics in apical periodontitis progression by a scoping review of animal and human studies. Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Extension for Scoping Reviews. The literature search and screening was performed on PubMed and Scopus databases by two independent reviewers selecting human and animal studies that evaluated the effectiveness of probiotics in reducing the severity of apical periodontitis. Two animal studies with 3 publications met the eligibility criteria for qualitative synthesis. The most common probiotics were Lactobacillus rhamnosus and Lactobacillus acidophilus orally administered for gavage in Wistar rats with induced apical periodontitis. Overall, probiotics significantly reduced inflammation and bone resorption with an improvement in the apical periodontitis progression. Although results in animal studies are promising, the use of probiotics in apical periodontitis progression requires caution due to the insufficient available evidence.

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“…Histological analysis showed that the control group with no probiotic administration had a more intense inflammatory infiltration than the treatment group. In addition, probiotics modulated inflammation and bone resorption in AP [ 77 ]. Another study showed a positive impact on the development and reduction of inflammation and bone resorption in rats with AP [ 78 ].…”

Section: Contemporary Therapiesmentioning

confidence: 99%

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

et al. 2023

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Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for the treatment of apical periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to increase the success rate of treatment for apical periodontitis. Some of these approaches remain in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear. The aim of this review was to summarize advanced approaches for the treatment of apical periodontitis. Further research can confirm the potential of these alternative nonsurgical endodontic treatment approaches.

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Dietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitis

Cited by 7 publications

References 32 publications

Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial

Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial

Effectiveness of probiotics in apical periodontitis progression: A scoping review and implications for research

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

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