Dietary supplementation with l-carnitine for Nile tilapia juveniles

Sanchez, Milena Souza dos Santos; Rodrigues, Mariana Lins; Pessini, Jhonis Ernzen; Bittencourt, Fábio; Boscolo, Wilson Rogério; Signor, Altevir

doi:10.1016/j.aquaculture.2021.736616

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…Several studies have been conducted to address the effect of LC in fish diets, and some authors have reported a positive impact on weight gain. Sanchez et al (2021) indicated that Nile tilapia juveniles (O. niloticus) showed better growth with 500 and 1000 mg kg -1 of LC in their diet, and the lipid content in their fillets was reduced. Wang et al (2019) reported increased growth and an antioxidant effect on the defense system when using 400-750 mg kg -1 of L-carnitine in the diet of amur minnow (Phoxinus lagowskii Dybowiskii).…”

Section: Discussionmentioning

confidence: 99%

“…Zootec., v.75, n.4, p.753-758, 2023 However, studies have shown contradictions about the use of L-carnitine (LC) as an additive to improve weight gain in fish. Some authors have reported positive effects, such as Asgharimoghadam et al (2014) on common carp (Cyprinus carpio) at 2500 mg kg -1 and Sanchez et al (2021) on Nile tilapia juveniles (Oreochromis niloticus). Nevertheless, no significant effects were observed by Yang et al (2009) for hybrid tilapia (Oreochromis niloticus × Oreochromis aureus) at 250 mg kg -1 .…”

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confidence: 99%

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Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Martins

Silva

Nascimento

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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L-carnitine perform a major role in transporting long-chain fatty acids into the mitochondria, where they are oxidized. It has been used in animal diets to decrease fat and increase muscle protein. The aim of this study was to evaluate the zootechnical performance, degree of steatosis in the liver, and genotoxic potential in Astyanax lacustris fed with different levels of L-carnitine (LC). Yellowtail tetra juveniles (n = 140) were distributed in 20 tanks of 70 L, with seven fish in each, in a water recirculation system with controlled temperature (27±0.1⁰C). The treatments with different levels of L-carnitine supplementation were: 0 (control), 250, 500, 750, and 1000 mg of LC per kg of food. The diets were provided twice a day for 60 days. The results showed that the different levels of LC did not affect (P>0.05) weight gain, survival, viscerosomatic index, and the liver hepatocytes showed a normal appearance. However, the use of LC supplementation showed genotoxic potential with a significant difference (P<0.05) for cell alterations when compared to the control at concentrations above 500mg kg-1.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Martins

Silva

Nascimento

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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“…The ingredients were used to formulate a control (optimum nutrients) diet containing approximately 480 g kg -1 protein and 130 g kg -1 lipid, a low protein and high fat (LPHF) diet containing approximately 420 g kg -1 protein and 150 g kg -1 lipid, and a LPHF diet supplemented with 500 mg kg -1 L-carnitine (LPHFC). The amount of Lcarnitine was based on previous studies in Nile tilapia [32] and Amur minnow (Phoxinus lagowskii) [33]. The diets were made and stored following a previous study in our laboratory [34].…”

Section: Introductionmentioning

confidence: 99%

Dietary L-Carnitine Alleviates the Adverse Effects Caused by Reducing Protein and Increasing Fat Contents in Diet Juvenile Largemouth Bass (Micropterus salmoides)

Liu

Limbu

Wang

et al. 2022

Aquaculture Nutrition

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Protein ingredients for formulation of fish feeds are expensive and have limited availability. Therefore, reducing dietary protein while increasing dietary fat content is a common practice in rearing carnivorous fish species. However, the ability of dietary L-carnitine to alleviate adverse effects in such diets is currently unknown. This study investigated the role of L-carnitine supplementation in alleviating adverse effects on growth performance, energy metabolism, antioxidant capacity, and inflammation response in juvenile largemouth bass (Micropterus salmoides) fed on a low protein and high fat diet. Three diets were formulated to contain low protein and high fat (LPHF: 420 g kg-1 protein and 150 g kg-1 lipid), LPHF supplemented with L-carnitine (LPHFC: 420 g kg-1 protein and 150 g kg-1 lipid), and a control diet (CON: 480 g kg-1 protein and 130 g kg-1 lipid). The diets were fed to 30 largemouth bass ( 10.75 ± 0.01 g) juveniles in triplicates for eight weeks. The results showed that the fish feed on LPHF diet increased hepatosomatic index, visceral somatic index, mesenteric fat index, whole-body crude fat content, serum and liver triglyceride concentrations, and serum non-esterified fatty acid level than those fed on CON diet. Moreover, the fish fed on LPHF diet increased serum alanine aminotransferase activity and liver malondialdehyde content and reduced superoxide dismutase (SOD) activities in the serum and liver. Furthermore, the fish fed on LPHF diet reduced the whole-body crude protein content. Interestingly, feeding the fish on the LPHFC diet decreased fat deposition and liver damage by downregulating the expression of genes related to lipogenesis, inflammation, and increased SOD activity. This study indicates that L-carnitine supplementation in largemouth bass alleviates the adverse effects caused by LPHF diet by decreasing lipogenesis and increasing lipid catabolism. Our study provides novel knowledge on strategies to improve utilization of LPHF diet in cultured aquatic animals.

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Dietary L-carnitine supplementation changes lipid metabolism and glucose utilization of Rhynchocypris lagowskii fed diets with different lipid sources

Wang

Guo

Wang

et al. 2023

Fish Physiol Biochem

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Dietary supplementation with l-carnitine for Nile tilapia juveniles

Cited by 9 publications

References 38 publications

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

Dietary L-Carnitine Alleviates the Adverse Effects Caused by Reducing Protein and Increasing Fat Contents in Diet Juvenile Largemouth Bass (Micropterus salmoides)

Dietary L-carnitine supplementation changes lipid metabolism and glucose utilization of Rhynchocypris lagowskii fed diets with different lipid sources

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