Dietary supplementation with Chinese herbal ultra‐fine powder enhances cellular and humoral immunity in early‐weaned piglets

Kong, Xiangfeng; Wu, Guoyao; Liao, Y.P.; Hou, Zhenping; Liu, H.J.; Yin, Fugui; Li, T.J.; Huang, Rui Xin; Zhang, Y.M.; Deng, Dun; Xie, Ming; Deng, Zeyuan; Xiong, Hua; Ruan, Zheng; Kang, Ping; Yang, Chengbo; Yin, Yulong; Fan, Ming Z.

doi:10.1016/j.livsci.2007.01.002

Cited by 67 publications

(62 citation statements)

References 11 publications

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“…After killing by decapitation, blood was collected and centrifuged for plasma separation, which was stored at -20°C for subsequent determination of arginine, glutamine, DAO and ET-1 concentrations (Deng et al 2010;Kong et al 2007;Yin et al 2010b). The small intestine was removed and the jejunum and ileum were separated, thoroughly fluxed with sterile saline (Yang et al 2011), immediately frozen in liquid nitrogen and then stored at -80°C for inflammatory cytokines mRNA analysis or fixed in 10% neutral buffered formalin for intestinal morphology.…”

Section: Sample Collectionmentioning

confidence: 99%

Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats

Zhou

Yin

et al. 2011

Amino Acids

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The objective of this study was to evaluate the effect of oral supplementation with a combination of arginine and glutamine on the intestinal mucosa and inflammatory cytokines of lipopolysaccharide (LPS)-induced adult rats. Fifty Sprague-Dawley rats (average weight of 185 ± 15 g) were randomly divided into five groups: control group A (CA) and control group B (CB), both orally supplemented with 0.9% saline; group Arg, supplemented with 300 mg/kg day(-1) arginine; group Gln, supplemented with 300 mg/kg day(-1) glutamine; group AG, supplemented with 150 mg/kg day(-1) arginine and 150 mg/kg day(-1) glutamine. The experiment lasted for 2 weeks. Food intake and body weight were measured during the experiment. At 10.00 h of day 15, animals were injected with 4 mg/kg LPS (group CB, Arg, Gln, and AG) or sterile saline (group CA) after supplementation. Then at 14.00 h, all animals were killed and blood and tissue collected. The results showed that compared with group CB, arginine concentration tended to be increased (P > 0.05) in group Arg and AG, while there was no significant difference in glutamine concentration among the groups challenged with LPS. Oral supplementation with arginine or/and glutamine mitigated morphology impairment (lower villus height, P < 0.05) in the jejunum and ileum induced by LPS challenge. LPS administration resulted in a significant increase in TNF-α, IL-1β, IL-6 and IL-10 mRNA abundance. Arginine only significantly decreased TNF-α mRNA abundance in the ileum, while glutamine significantly decreased both TNF-α and IL-10 mRNA in the ileum. A combination of arginine and glutamine significantly decreased TNF-α and IL-1β mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum. These results revealed that an oral supply of combined arginine and glutamine had more favorable effects on the intestinal mucosa and inflammatory cytokines than a supply of arginine or glutamine alone.

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Section: Sample Collectionmentioning

confidence: 99%

Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats

Zhou

Yin

et al. 2011

Amino Acids

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“…The serum concentrations of IGF-I, interleukin 6 (IL-6) and tumor necrosis factor-a (TNF-a) were determined using a radioimmunoassay method with kits for porcine assay and were commercially available from Chemclin Biotech Co., Ltd (Beijing, China; Kong et al, 2007). All samples were measured in six replicates.…”

Section: Blood Parametersmentioning

confidence: 99%

Regulation of soy isoflavones on weight gain and fat percentage: evaluation in a Chinese Guangxi minipig model

Yang

et al. 2011

Animal

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This study was conducted to determine the effects of soy isoflavones on changes in body and tissue weight and on insulin-like factor I (IGF-I) and peroxisome proliferator-activated receptor-g (PPARg) gene and protein expression in muscle and adipose tissues in Chinese Guangxi minipig, as a model for studying human nutrition. A total of 72 male Chinese Guangxi minipigs were fed basal diet (control, Con), low dose of soy isoflavones and high dose of soy isoflavones (HSI). The results showed that HSI increased the body weight (BW) gain and fat percentage of minipigs (P , 0.05). In addition, the serum concentrations of IGF-I and interleukin-6 were increased by high levels of soy isoflavones (P , 0.05). Furthermore, a diet containing soy isoflavones enhanced IGF-I mRNA expression levels in longissimus muscle, but decreased these levels in perirenal fat. However, the mRNA and protein expression levels of PPARg in longissimus muscle and subcutaneous adipose tissue were both increased when compared with the Con. The data indicated that soy isoflavones regulated the BW gain and fat percentage of Chinese Guangxi minipigs, which also showed changes in IGF-I system and PPARg. However, further research is required to clarify the causative relationship.

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“…A total of 60 Duroc × Landrace × Yorkshire piglets with an average live BW of 5.64 kg were weaned at 21 days of age and randomly assigned to one of the 3 treatment groups, representing dietary supplementation with 0 or 2 g/kg of the herbal powder, or 0.2 g/kg of colistin (an antibiotic), on the basis of litter, BW and sex, as described by Kong et al (2006). Colistin is an antibiotic commonly used for preventing and treating diarrhea in weanling piglets, and its dose of 0.2 g/kg used in our study was chosen according to the manufacturer's instructions.…”

Section: Animal Housing and Treatmentmentioning

confidence: 99%

“…Therefore, weaning is associated with growth retardation as well as an increase in both morbidity and mortality in piglets (Wilson et al, 1989). On the basis of our recent finding that dietary supplementation with a Chinese herbal ultra-fine powder enhanced both cellular and humoral immunity in earlyweaned piglets (Kong et al, 2006), we hypothesized that such a treatment could improve growth performance and intestinal health in the neonates.…”

Section: Introductionmentioning

confidence: 99%

Effects of Chinese herbal ultra-fine powder as a dietary additive on growth performance, serum metabolites and intestinal health in early-weaned piglets

Kong

Liao³

et al. 2007

Livestock Science

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Dietary supplementation with Chinese herbal ultra‐fine powder enhances cellular and humoral immunity in early‐weaned piglets

Cited by 67 publications

References 11 publications

Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats

Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats

Regulation of soy isoflavones on weight gain and fat percentage: evaluation in a Chinese Guangxi minipig model

Effects of Chinese herbal ultra-fine powder as a dietary additive on growth performance, serum metabolites and intestinal health in early-weaned piglets

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