Dietary Supplementation with Chestnut (Castanea sativa) Reduces Abdominal Adiposity in FVB/n Mice: A Preliminary Study

Abstract

The production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the effects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6): 1 (control group) fed a standard diet; 2 fed a diet supplemented with 0.55% (w/w) chestnut; and 3 supplemented with 1.1% (w/w) chestnut. Body weight, water, and food intake were recorded weekly. Following 35 days of supplementation, the mice were sacrificed for the collection of biological samples. Chestnut supplementation at 1.1% reduced abdominal adipose tissue. Lower serum cholesterol was also observed in animals supplemented with chestnut. There were no significant differences concerning the incidence of histological lesions nor in biochemical markers of hepatic damage and oxidative stress. These results suggest that chestnut supplementation may contribute to regulate adipose tissue deposition.

Reduction in Spoilage Microbiota and Cyclopiazonic Acid Mycotoxin with Chestnut Extract Enriched Chitosan Packaging: Stability of Inoculated Gouda Cheese

“…The higher reactivity is related to sufficient amine groups and higher M w [ 25 ]. Studies report chestnut extract tannins interactions with abdominal cholesterol and thus lowering adiposity in mice [ 26 ], a decrease in Cladosporium cladosporioides on sheep cheese rind [ 7 ], L. monocytogenes in Emmental cheese [ 27 ], E. coli , P. fluorescens in mozzarella cheese [ 28 ], and reduction in mycotoxins [ 29 ]. Yet even though the chestnut extract is widely spread, there seems to be a gap in knowledge of how the component combines with chitosan to prevent food spoilage.…”

A Brief Overview of Oxidative Stress in Adipose Tissue with a Therapeutic Approach to Taking Antioxidant Supplements

“…Rodrigues et al [103] FVB/n male 7-month-old mice Chestnut at a dose of 1.1%. The reduction of serum cholesterol and AT deposition.…”

“…In another study, Rodrigues et al (2020) examined the effect of consuming an antioxidant fruit called chestnut at a dose of 1.1% in 18 FVB/Nn male 7-month-old mice. They concluded that this supplement reduced adipose tissue, serum cholesterol, and adipose tissue deposition [ 103 ].…”

Rapid diagnostics for Gnomoniopsis smithogilvyi (syn. Gnomoniopsis castaneae) in chestnut nuts: new challenges by using LAMP and real-time PCR methods

“…Several studies highlighted the nutritional qualities and potentially valuable health effects of chestnuts. Chestnut is a low-fat fruit, rich in vitamins, minerals, sugars and several other compounds, including the ω-3 and ω-6 polyunsaturated fatty acids (PUFA) tocopherol and linoleic acid, that reduce a person's risk of developing diseases (Barreira et al 2009 ; De Vasconcelos et al 2010 ; Li et al 2007 ; Rodrigues et al 2020 ; Simopoulos 1991 ).…”