Dietary supplementation of milk fermented with probiotic Lactobacillus fermentum enhances systemic immune response and antioxidant capacity in aging mice

Sharma, Rohit; Kapila, Rajeev; Kapasiya, Meena; Saliganti, Vamshi; Dass, Gopal; Kapila, Suman

doi:10.1016/j.nutres.2014.09.006

Cited by 69 publications

(42 citation statements)

References 52 publications

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“…Besides vitamin D (the most important of all nutraceuticals for immune function), other vitamins that strengthen immunity include vitamin C and vitamin E (De la Fuente et al 1998;Moriguchi and Muraga 2000). Zinc (Barnett et al 2016) (80 mg/day during period of infection) and probiotics (Sharma et al 2014) have also been shown to benefit the immune system.…”

Section: Pay Attention To Physical Healthmentioning

confidence: 99%

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

2020

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Anxiety and fear adversely affect the physiological systems that protect individuals from infection. This article comments on the role that religious faith and practice can play in helping individuals remain free from infection by the coronavirus and in helping to moderate the effects of infection if that should occur. The author provides six recommendations to help individuals maintain spiritual, mental, and physical resilience during these anxious times of the COVID-19 pandemic.

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Section: Pay Attention To Physical Healthmentioning

confidence: 99%

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

2020

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“…There is an increasing amount of studies which support the potential health benefits of probiotics, such as the stimulation of immunity, reduction of oxidative stress (Lamprecht et al 2012;Sharma et al 2014), improvement of gastrointestinal barrier (Lamprecht et al 2012), promotion of antitumor activity (Thomas and Ockhuizen, 2012) etc. Lactobacillus and Bifidobacterium are the most widely used and studied probiotic bacteria, due to their safety, and abundance in food preparations (Fijan 2014).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial

Michaličková

Minić

Dikić

et al. 2016

Appl. Physiol. Nutr. Metab.

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A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 × 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 ± 2.90 vs. 10.64 ± 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 ± 1.96 vs. 6.91 ± 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-β serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-γ level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F[1,37] = 6.99, p = 0.020, η(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F[1,37] = 11.76, p = 0.009, η(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 ± 4.1 vs. 21.0 ± 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.

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“…Probiotics have been investigated for their ability to modulate the immune system, with the aim to prevent and/or limit the effects of immunosenescence [44,][45]. In nursing-home populations, several Bifidobacterium and Lactobacillus probiotic strains have been reported to have positive effects by reducing inflammatory status and duration of winter infections [46,][47].…”

Section: Probiotics In the Older Peoplementioning

confidence: 99%

Gastrointestinal Microbiota and Their Contribution to Healthy Aging

Mello

Paroni

Daragjati

et al. 2016

Dig Dis

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Studies on populations at different ages have shown that after birth, the gastrointestinal (GI) microbiota composition keeps evolving, and this seems to occur especially in old age. Significant changes in GI microbiota composition in older subjects have been reported in relation to diet, drug use and the settings where the older subjects are living, that is, in community nursing homes or in a hospital. Moreover, changes in microbiota composition in the old age have been related to immunosenescence and inflammatory processes that are pathophysiological mechanisms involved in the pathways of frailty. Frailty is an age-related condition of increased vulnerability to stresses due to the impairment in multiple inter-related physiologic systems that are associated with an increased risk of adverse outcomes, such as falls, delirium, institutionalization, hospitalization and death. Preliminary data suggest that changes in microbiota composition may contribute to the variations in the biological, clinical, functional and psycho-social domains that occur in the frail older subjects. Multidimensional evaluation tools based on a Comprehensive Geriatric Assessment (CGA) have demonstrated to be useful in identifying and measuring the severity of frailty in older subjects. Thus, a CGA approach should be used more widely in clinical practice to evaluate the multidimensional effects potentially related to GI microbiota composition of the older subjects. Probiotics have been shown to be effective in restoring the microbiota changes of older subjects, promoting different aspects of health in elderly people as improving immune function and reducing inflammation. Whether modulation of GI microbiota composition, with multi-targeted interventions, could have an effect on the prevention of frailty remains to be further investigated in the perspective of improving the health status of frail ‘high risk' older individuals.

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Dietary supplementation of milk fermented with probiotic Lactobacillus fermentum enhances systemic immune response and antioxidant capacity in aging mice

Cited by 69 publications

References 52 publications

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

Maintaining Health and Well-Being by Putting Faith into Action During the COVID-19 Pandemic

Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial

Gastrointestinal Microbiota and Their Contribution to Healthy Aging

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