Dietary supplementation of guanidinoacetic acid improves growth, biochemical parameters, antioxidant capacity and cytokine responses in Nile tilapia (Oreochromis niloticus)

Aziza, Abeer; Mahmoud, Rania; Zahran, Eman; Gadalla, Hossam

doi:10.1016/j.fsi.2019.12.052

Cited by 22 publications

(10 citation statements)

References 57 publications

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“…These substances directly scavenge free radicals and improve the antioxidant defense system 8,9 . A previous study showed that the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) exhibited a significant increase, and the malondialdehyde (MDA) content was significantly decreased with the supplementation of GAA in broilers 10 …”

Section: Introductionmentioning

confidence: 99%

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Zhao

Xing

et al. 2021

J Sci Food Agric

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BACKGROUND This study was conducted to evaluate the effects of adding guanidinoacetic acid (GAA), or complex antioxidant (CA), or their combination, in diets on the growth performance, carcass traits, meat quality, and antioxidant capacity of broilers. A total of 192 25‐day‐old broilers were assigned to a 2 × 2 factorial design including two dietary supplements at two different levels, in which the main effects were the addition of GAA (0 or 600 mg kg−1) and CA (0 or 150 mg kg−1). This trial lasted for 18 days. RESULTS Compared with the control group, the GAA group, CA group, and GAA + CA group, decreased feed conversion ratio by 7.02%, 6.58%, and 11.40%, respectively. Guanidinoacetic supplementation increased eviscerated yield, pH24h (P < 0.05). Complex antioxidant supplementation increased the a* values (P < 0.05). The combination of GAA and CA did not affect the carcass traits and meat quality. Guanidinoacetic acid alone and CA alone and combined with GAA and CA decreased the reactive oxygen species (ROS) level and malonaldehyde (MDA) content (P < 0.05), and the GAA + CA group had the lowest ROS level and MDA content of broilers. CONCLUSION Dietary supplementation of GAA, CA or their combination had beneficial effects on growth performance and breast antioxidant capacity, and the combination of GAA and CA could exert a synergistic effect in improving antioxidant capacity. © 2020 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Zhao

Xing

et al. 2021

J Sci Food Agric

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“…Still, GAA as a food supplement has been used for chickens and pigs to improve growth, breast meat yield and feed conversion ratio 68–71 . In Nile tilapia ( Oreochromis niloticus [Linnaeus]), GAA increased growth rates at 0.6–1.8 g kg −1 after 60 days of supplementation 38 . Nevertheless, in a similar study at the same concentrations, GAA did not increase growth performance or feed efficiency in this species 39 .…”

Section: Application Form Of Creatinementioning

confidence: 89%

Creatine: A valuable supplement in aquafeeds?

Wuertz

Reiser

2022

Reviews in Aquaculture

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Creatine is an amino acid derivate commonly found in vertebrate muscle tissue. Creatine facilitates the recycling of adenosine triphosphate and thus contributes to the energy supply of the muscles as well as the brain. Creatine is used as a supplement for several reasons and its effects in humans, particularly in sports medicine, have been studied excessively. Also, creatine supplementation has been studied for its functions and benefits in terrestrial farm animals. Up to date, little is known about the use of creatine as a supplement in fish nutrition. Yet, due to its many physiological functions, creatine may serve as a valuable supplement in aquafeeds of farmed aquaculture species. Indeed, creatine plays a pivotal role in the fish's muscle and may help to enhance performance of fish reared in aquaculture systems. With regard to swimming exercise, creatine may even amplify its metabolic effects. Upon supplementation, creatine stimulates muscle growth increasing body mass and it has the potential to improve feed utilisation particularly of plant-based diets. Also, creatine plays a part in osmoregulation when fish adapt to changes in salinity. Furthermore, it may improve product quality upon slaughter. Here, we compile what is known about the many functions of creatine as well as its physiological effects in fish in comparison to mammals. We also highlight its potential beneficial effects as a supplement in aquaculture and infer why creatine can help increase the sustainability of fish feeds.

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“…Nile tilapia ( Oreochromis niloticus ) were fed diets containing GAA up to 1.5× the maximum use level for 60 days (Aziza et al., 2020 ). Growth performance, biochemical parameters and antioxidant capacity were measured.…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of guanidinoacetic acid for all animal species (Alzchem Trostberg GmbH)

Bampidis¹,

Azimonti²,

Bastos³

et al. 2022

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) when used as nutritional additive in feed and water for drinking for all animal species. The FEEDAP Panel concludes that GAA at 1,200 mg/kg complete feed is safe for chickens for fattening, piglets and pigs for fattening. This concentration in complete feed would correspond to maximum concentrations in water of 600 mg GAA/L for chickens for fattening, piglets and pigs for fattening. The Panel is not in a position to conclude on a safe level of GAA in laying/reproductive birds. In the absence of data on ruminants and salmonids, the FEEDAP Panel cannot conclude on the safety of GAA for all animal species. There is no concern on consumer safety resulting from the use of GAA in feed for poultry and pigs at the proposed conditions of use. The limited data do not allow to conclude on the safety for the consumer when the additive is used in feed for ruminants or fish. GAA is not toxic by inhalation, it is not an irritant to skin and eyes, and it is not a dermal sensitiser. The FEEDAP Panel concludes that the use of GAA as feed additive is not expected to pose a risk to the environment. The use of the additive under assessment in animal nutrition at the proposed conditions of use has the potential to be efficacious in all growing avian, Suidae and ruminant (except for preruminants) species; in growing fin fish other than salmonids and in frog. It is not possible to conclude on the efficacy of the additive in other species, and in reproductive animals.

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Dietary supplementation of guanidinoacetic acid improves growth, biochemical parameters, antioxidant capacity and cytokine responses in Nile tilapia (Oreochromis niloticus)

Cited by 22 publications

References 57 publications

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Creatine: A valuable supplement in aquafeeds?

Safety and efficacy of a feed additive consisting of guanidinoacetic acid for all animal species (Alzchem Trostberg GmbH)

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