Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Kotani, Susumu; Sakaguchi, Eiko; Warashina, Shogo; Matsukawa, Noriyuki; Ishikura, Yoshiyuki; Kiso, Yoshinobu; Sakakibara, Manabu; Yoshimoto, Tanihiro; Guo, Jian-Zhong; Yamashima, Tetsumori

doi:10.1016/j.neures.2006.06.010

Cited by 290 publications

(186 citation statements)

References 37 publications

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“…We should note that imbalances of PLA2 have been shown to be opposite between schizophrenia and Alzheimer's disease patients [38,39,69,72,82,86,89], diseases that also present distinct cognitive deficits [90]. Our findings reinforce the positive impact of the chronic use of lithium in memory-even when given at low concentrations that should reduce its cytotoxicity-and suggest that Pla2 may have a role in neurochemical cascades that affect memory.…”

Section: Discussionsupporting

confidence: 68%

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Mury

Silva

Barbosa

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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a significant perdurability of long-term memory, which correlated with increased transcriptional and enzymatic activities of certain members of the Pla2 family (iPla2 and sPla2) after the chronic lithium treatment. Our data suggest new possible targets of lithium, add more information on its pharmacological activity and reinforce the possible use of low doses of lithium for the treatment of neurodegenerative conditions such as the Alzheimer's disease.

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Section: Discussionsupporting

confidence: 68%

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Mury

Silva

Barbosa

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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“…There are many similarities between the neural effects of rearing under EC and of chronically administering DHA, or UMP plus DHA. EC rodents exhibit improved spatial memory [8], while administration of DHA improves cognitive impairment in mouse models of mild cognitive dysfunction or in AD [51]. C57BL/6 learning-impaired mice [52] show increased survival of hippocampal cells if exposed to an EC, while DHA prolongs cell survival in retinal photoreceptors [53].…”

Section: Discussionmentioning

confidence: 99%

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Holguin

Huang

Liu

et al. 2008

Behavioural Brain Research

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Living in an enriched environment (EC) during development enhances memory function in adulthood; living in an impoverished environment (IC) impairs memory function. Compounds previously demonstrated to improve memory among IC rats include CDP-choline and uridine monophosphate (UMP). Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDPcholine. It also uses the polyunsaturated fatty acid (PUFA) DHA, a precursor for the diacylglycerol incorporated into PC. DHA administration also improves cognition in young and aged rodents and humans; its effects on cognitively-impaired IC rats have not been characterized. We have thus examined the consequences of administering DHA (300 mg/kg ) by gavage, UMP (0.5% in the diet), or both compounds on hippocampal-and striatal-dependent forms of memory among rats exposed to EC or IC conditions for 1 month starting at weaning, and consuming a choline-containing diet. We observe that giving IC rats either dietary UMP or gavaged DHA improves performance on the hidden version of the Morris water maze (all P<0.05), a hippocampal-dependent task; coadministration of both phosphatide precursors further enhances the IC rats' performance on this task (P<0.001). Neither UMP, DHA, nor both compounds affects the performance of EC rats on the hidden version of the Morris water maze (P>0.05), nor the performance by IC or EC rats on the visible version of the Morris water maze (all P>0.05), a striatal-dependent task. We confirm that coadministration of UMP and DHA to rats increases brain levels of the phosphatides PC, PE, SM, PS, PI, and total brain phospholipid levels (all p<0.05), and show that rearing animals in an enriched environment also elevates brain PC, PS, and PI levels (all p<0.01) and total brain phospholipids (p<0.01) compared with their levels in animals reared in an IC environment. These findings suggest that giving DHA plus UMP can ameliorate memory deficits associated with rearing under impoverished conditions, and that this effect may be mediated in part through enhanced synthesis of brain membrane phosphatides.

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“…Several clinical studies indicate that oral administration of EPA can improve emotional and cognitive function in schizophrenic patients (Mellor et al, 1995;Arvindakshan et al, 2003a,b). Likewise, AA (Kotani et al, 2006) and DHA (Horrocks and Yeo, 1999) supplementation can improve cognitive dysfunction seen in human disorders such as Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain

Shioda¹,

Yamamoto²,

Watanabe³

et al. 2010

J. Neurosci.

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Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Cited by 290 publications

References 37 publications

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain

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Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Cited by 290 publications

References 37 publications

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D2Receptor Function in Mouse Brain

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Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain