Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats

Rosillo, María Ángeles; Sánchéz-Hidalgo, Marina; Cárdeno, Ana; Aparicio‐Soto, Marina; Sánchez-Fidalgo, Susana; Villegas, Isabel; Lastra, Catalina Alarcón de la

doi:10.1016/j.phrs.2012.05.006

Cited by 152 publications

(116 citation statements)

References 42 publications

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“…It should be stressed that a substantial number of dietary polyphenols have been found to express anti-inflammatory and anti-cancer properties. Thus, ellagic acid present in pomegranates was shown to reduce the expression of NF-κB, COX2, TNF-α and IL-6 and to exert both anti-inflammatory and carcinopreventive effects [83,84] . Polyphenol-rich apple diet administered to rats inhibited TNF-α, iNOS, IL-1β and IL-6 mRNA expression in the colon and diminished the number of CD68 cells [85] .…”

Section: Resveratrolmentioning

confidence: 99%

Modulators affecting the immune dialogue between human immune and colon cancer cells

Djaldetti¹

2014

WJGO

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Section: Resveratrolmentioning

confidence: 99%

Modulators affecting the immune dialogue between human immune and colon cancer cells

Djaldetti¹

2014

WJGO

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“…Ellagicacid inhibits upregulation of COX-2 and reduces IL-6 and increase IL-10 levels in 0.1N HCl induced acute lung injury in mice modelvia its anti-inflammatory mechanism [61] . Ellagic acid decrease TNF-α, inhibit COX-2 & iNOS and block the activation of NF-κB pathway in trinitrobenzene sulfonic acid induced chronic colonic inflammation in rats [105] . Ellagic acid also reduce the expressions of NF-κB, COX-2, iNOS, TNF-α and IL-6 in 1,2-Dimethylhydrazineinduced rat colon carcinogenesis [106] .…”

Section: Ellagic Acid and Neuroinflammationmentioning

confidence: 93%

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Mehan¹,

Kaur²,

Parveen³

et al. 2015

International Journal of Neurology Research

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Alzheimer's disease is a severe neurodegenerative disorder that gradually results in loss of memory and impairment of cognitive functions in the elderly.Thedeposition of amyloid plaques is the primary event that leads to an oxidative and inflammatory reactions, neurofibrillary tangle formation, and ultimately neuronal death. The most prominent losses occur with cholinergic neurons that plays an important role in the formation of memory and cognitive functions. Insulin receptor numbers also altered, thusglucosemetabolism is defected in AD. Polyphenol ellagic acid (EA) possesses antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and cardioprotection activities.Activities of EA that are linked with protection of neuronal abnormalities like anti-depressant, antianxiety, anti-nociception. Ellagic acid inhibits β-secretase enzymatic activities, thus prevents the main pathologic hallmark of AD. There are varieties of herbal extracts and phytochemicals formulations extensively used to provide symptomatic relief to AD patients. Together these results our hypothesis that EA may prevent the neuronal dysfunctions as well as further work is also required to examine the pharmacological properties of EA in the protection of specially neurodegenerative disorder like AD. Here, we discuss how we can use the knowledge to improve treatment strategies of EA in AD and to explore the various signaling pathways involved in the progression of neuronal death.

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“…In vivo study reported that ellagic acid also improves UC in mice after induced by dextran sodium sulfate (DSS). Ellagic acid inhibits intestinal inflammation, lowers COX-2 and iNOS expressions, and blocks inflammatory signal pathway NF-κB [20]. Pomegranate peel extract inhibits COX-2 expression on the colon and visceral adipose tissue at 6 mg daily in mice for 4 weeks [21].…”

Section: Kusmardi Et Almentioning

confidence: 99%

“…The pure ellagic acid (ELG) dose used in this experiment was similar to previously described by Rosillo et al [20], and conversion of the dose was according to US Food and Drug Administration [23]. The dose of aspirin (ASP) was based on previously published reports Al-Swayeh et al [24].…”

Section: Experimental Designmentioning

confidence: 99%

“…The dose of pomegranate peel ethanol extract was calculated after first identification of ellagic acid levels in a preliminary study using high-performance liquid chromatography. The ellagic acid levels were obtained and then synchronized with a pure ellagic acid dose by Rosillo et al [20]. A preliminary study of identification ellagic acid in pomegranate peel ethanol extract was based on previously published reports by Panichayupakaranant et al [25].…”

Section: Experimental Designmentioning

confidence: 99%

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The Potency of Indonesia’s Pomegranate Peel Ethanol Extract (Punica Granatum Linn.) as Anti-Inflammatory Agent in Mice Colon Induced by Dextran Sodium Sulfate: Focus on Cyclooxygenase-2 and Inos Expressions

Kusmardi

Hermanto

Estuningytas

et al. 2017

Asian J Pharm Clin Res

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Objective: Inflammatory disease occurs in the mucosal of the colon, or ulcerative colitis (UC) is one of subtypes of inflammatory bowel disease. The numerous of drug side effects for treatment of colitis give rise to use medicinal herbs as alternative therapies. Pomegranate peel extract has been used for the treatment of pain and inflammatory conditions. This study aimed to investigate the anti-inflammatory effects of pomegranate peel ethanol extract on mice colon through inflammation pathway which reduce inflammation score in mice model of chronic inflammation induced by dextran sodium sulfate (DSS).Methods: Thirty Swiss Webster mice divided randomly into 6 groups: Normal, aspirin 43 mg/kg/d (ASP), ellagic acid 26 mg/kg/d (ELG), DSS 2%b/v (DSS), pomegranate peel ethanol extract 240 mg/kg/d (DOSES-1), and 480 mg/kg/d (DOSES-2). All groups were given DSS 2% over 3 cycles except normal group (where each cycle in the DSS group consisted of 2% DSS in drinking water for 7 days, followed by a 7-day interval with normal drinking water). At the end of the experiment, colon samples were washed with water then buffered neutral formalin 10% fixed and paraffin embedded for histological analysis.Results: DOSES-1 and DOSES-2 were significantly reduced inflammation score in colon mice induced by DSS (p<0.05), mean score 2.01 and 2.02. Expression of cyclooxygenase (COX-2) was significantly decreased (p<0.05), mean score 27.48 and 17.77. Expression of iNOS was also significantly decreased (p<0.05), mean score 54.01 and 36.69. There were no significant differences between DOSES-1 and DOSES-2 groups with ASP and ELG group (p>0.05). Conclusion:Pomegranate peel ethanol extract has an anti-inflammatory agent by reduces inflammation score, inhibiting COX-2 and iNOS expression on mice colon by DSS induced. Furthermore, pomegranate peel ethanol extract has equivalent effectiveness with aspirin and pure ellagic acid.

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Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats

Cited by 152 publications

References 42 publications

Modulators affecting the immune dialogue between human immune and colon cancer cells

Modulators affecting the immune dialogue between human immune and colon cancer cells

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

The Potency of Indonesia’s Pomegranate Peel Ethanol Extract (Punica Granatum Linn.) as Anti-Inflammatory Agent in Mice Colon Induced by Dextran Sodium Sulfate: Focus on Cyclooxygenase-2 and Inos Expressions

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