Dietary Supplement Use Pattern of U.S. Adult Population in the 2007–2008 National Health and Nutrition Examination Survey (NHANES)

Kennedy, Eileen; Luo, Hanqi; Houser, Robert F.

doi:10.1080/03670244.2012.706000

Cited by 57 publications

(64 citation statements)

References 4 publications

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“…The results presented here both corroborate past research and provide an expansion of the topic by exploring details behind DS and pharmaceutical co-use. For example, this analysis illustrates that recent DS users (any quantity) are more likely to be older and women, in line with other prior national surveys such as the 2007-2008 update to the National Health and Nutrition Examination Survey (NHANES) and the National Health Interview Survey (NHIS) [1, 3, 22, 23]. In contrast, this analysis showed a similar amount of education between the DS cohort and the whole cohort; in other trials, DS users are often more likely to be more highly educated.…”

Section: Discussionsupporting

confidence: 78%

The Overlap of Dietary Supplement and Pharmaceutical Use in the MIDUS National Study

Kiefer

Chase

Love

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Introduction. In the United States, dietary supplement (DS) use is common, often takes place outside of the purview of health care providers, and may involve DS in combination with pharmaceuticals. This situation has led to concerns about interactions between DS and pharmaceuticals, as well as the risks from polypharmacy and polysupplement use. Methods. We used data from the Midlife in the US study (MIDUS 2 Survey) to examine DS and prescription pharmaceutical use in 3876 study participants in order to determine the demographics of high-users (5 or more) of DS and pharmaceuticals and the presence of DS-pharmaceutical co-use. Results. Over 69% of study participants regularly used DS, 49.6% regularly used both DS and pharmaceuticals, and 6.3% and 8.7% were high-users of pharmaceuticals and DS, respectively. High-users of DS, pharmaceuticals, and either were more likely than the whole cohort to be female and of lower income. Conclusions. These findings corroborate those of other national studies with respect to the demographics of DS users but add new information about people at risk of DS-pharmaceutical interactions, not an insignificant proportion of the population examined by this dataset.

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Section: Discussionsupporting

confidence: 78%

The Overlap of Dietary Supplement and Pharmaceutical Use in the MIDUS National Study

Kiefer

Chase

Love

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…; Kennedy et al . ). Isolated vitamin C and E supplements are among the most commonly used, despite tentative evidence for the purported effects of these vitamins on health, sport performance and recovery from muscle damage (Padayatty et al .…”

Section: Introductionmentioning

confidence: 97%

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double‐blind, randomised, controlled trial

Paulsen

Cumming

Holden

et al. 2014

The Journal of Physiology

251

239

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Key pointsr Recent studies have indicated that antioxidant supplementation may blunt adaptations to exercise, such as mitochondrial biogenesis induced by endurance training. However, studies in humans are sparse and results are conflicting.r Isolated vitamin C and E supplements are widely used, and unravelling the interference of these vitamins in cellular and physiological adaptations to exercise is of interest to those who exercise for health purposes and to athletes.r Our results show that vitamin C and E supplements blunted the endurance training-induced increase of mitochondrial proteins (COX4), which is important for improving muscular endurance.r Training-induced increases inV O 2 max and running performance were not detectably affected by the supplementation.r The present study contributes to understanding of how antioxidants may interfere with adaptations to exercise in humans, and the results indicate that high dosages of vitamins C and E should be used with caution.Abstract In this double-blind, randomised, controlled trial, we investigated the effects of vitamin C and E supplementation on endurance training adaptations in humans. Fifty-four young men and women were randomly allocated to receive either 1000 mg of vitamin C and 235 mg of vitamin E or a placebo daily for 11 weeks. During supplementation, the participants completed an endurance training programme consisting of three to four sessions per week (primarily of running), divided into high-intensity interval sessions [4-6 × 4-6 min; >90% of maximal heart rate (HR max )] and steady state continuous sessions (30-60 min; 70-90% of HR max ). Maximal oxygen uptake (V O 2 max ), submaximal running and a 20 m shuttle run test were assessed and blood samples and muscle biopsies were collected, before and after the intervention. Participants in the vitamin C and E group increased theirV O 2 max (mean ± S.D.: 8 ± 5%) and performance in the 20 m shuttle test (10 ± 11%) to the same degree as those in the placebo group (mean ± S.D.: 8 ± 5% and 14 ± 17%, respectively). However, the mitochondrial marker cytochrome c oxidase subunit IV (COX4) and cytosolic peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1α) increased in the m. vastus lateralis in the placebo group by 59 ± 97% and 19 ± 51%, respectively, but not in the vitamin C and E group (COX4: −13 ± 54%; PGC-1α: −13 ± 29%; P ࣘ 0.03, between groups). Furthermore, mRNA levels of CDC42 and mitogen-activated protein kinase 1 (MAPK1) in the trained muscle were lower in the vitamin C and E group than in the placebo group (P ࣘ 0.05). Daily vitamin C and E supplementation attenuated increases in markers of mitochondrial biogenesis following endurance training. However, no clear interactions were detected for improvements inV O 2 max and running performance. Consequently, vitamin C and E supplementation hampered cellular adaptations in the exercised muscles, and although this did not translate to the performance tests applied in this study, we advocate caution when considering antioxidant supplemen...

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“…26 Men in the top quintile of folate intake from supplements and fortified foods (DFE) in our study population had an intake level of 1.5 to 3.9 mg per day, above the recommended daily limit of consumption (tolerable upper limit 1 mg per day). Nonetheless, the deleterious effects of folate consumption on prostate cancer progression, if they exist, may not become evident until serum levels are supraphysiological (intake greater than 1 mg per day).…”

Section: Discussionmentioning

confidence: 72%

Impact of Folate Intake on Prostate Cancer Recurrence Following Definitive Therapy: Data from CaPSURE™

et al. 2014

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Purpose A randomized, placebo controlled clinical trial of folic acid supplementation for the chemoprevention of colorectal adenoma revealed an increased incidence of prostate cancer in the treatment group. Limited data exist on postdiagnostic folate/folic acid intake and the risk of prostate cancer progression. We prospectively examined the association between postdiagnostic folate consumption and the risk of prostate cancer recurrence after radical prostatectomy, external beam radiation therapy and brachytherapy. Materials and Methods This study was done in 1,153 men treated with radical prostatectomy, external beam radiation therapy and brachytherapy who had clinical stage T1-T2c prostate adenocarcinoma and participated in the CaPSURE Diet and Lifestyle substudy by completing the semiquantitative Food Frequency Questionnaire in 2004 to 2005. We used Cox proportional hazards regression to analyze the association between folate intake and prostate cancer progression. Results Prostate cancer progressed in 101 men (8.76%) during a mean 34-month followup. After multivariate adjustment we observed no evidence of an association of the intake of total folate, dietary folate or dietary folate equivalents with prostate cancer recurrence. On secondary analysis by treatment after radical prostatectomy patients in the lowest decile of dietary folate intake had a 2.6-fold increase in the risk of recurrence (HR 2.56, 95% CI 1.23–5.29, p = 0.01). In patients treated with external beam radiation and brachytherapy we observed no evidence of an association between prostate cancer progression and increased folate intake. Conclusions Results suggest that the consumption of foods and multivitamins that contain folate is not associated with prostate cancer progression after definitive treatment.

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Dietary Supplement Use Pattern of U.S. Adult Population in the 2007–2008 National Health and Nutrition Examination Survey (NHANES)

Cited by 57 publications

References 4 publications

The Overlap of Dietary Supplement and Pharmaceutical Use in the MIDUS National Study

The Overlap of Dietary Supplement and Pharmaceutical Use in the MIDUS National Study

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double‐blind, randomised, controlled trial

Impact of Folate Intake on Prostate Cancer Recurrence Following Definitive Therapy: Data from CaPSURE™

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