Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr ApoB100/100 mice

Distinct Influence of Hypercaloric Diets Predominant with Fat or Fat and Sucrose on Adipose Tissue and Liver Inflammation in Mice

“…While this hypothesis remains tentative and requires more rigorous experimentation, the observations that HFHS-fed mice displayed less crown-like structures and inflammatory macrophages in adipose tissues are consistent with this hypothesis. Interestingly, our results are in striking contrast to a recent report that dietary sucrose induces metabolic inflammation, including inflammation in adipose tissues, more than dietary fat in Ldlr −/− ApoB 100/100 mice [ 41 ]. However, there are key differences between the 2 studies that led to the disparate conclusions.…”

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

“…However, hyperglycemia is common to their diagnosis, drives cardiovascular risk in each, and has been the mainstay target of treatments and monitoring for both types of diabetes for many years. We expect that the newly identified hyperglycemia-induced trained immunity reported here will be elaborated in the future to take into account more specific modulation in relation to many other potential influences (eg, dietary sugar, 66 patterns of glucose elevation, 67 concomitant hyperlipidemia 57 ).…”

The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons

“…It was interesting, although not altogether unexpected, that the HS diet did not cause significant weight gain. It has previously been reported that mice fed a HF diet display increased obesity and insulin resistance compared to mice fed a HS diet ( Perazza et al, 2020 ). Additionally, HF diets can cause significant alterations to the size and morphology of adipocytes as well as increasing inflammatory mediators in visceral adipose tissue ( Dobner et al, 2017 ).…”