Dietary strawberry seed oil affects metabolite formation in the distal intestine and ameliorates lipid metabolism in rats fed an obesogenic diet

Abstract

ObjectiveTo answer the question whether dietary strawberry seed oil rich in α-linolenic acid and linoleic acid (29.3 and 47.2% of total fatty acids, respectively) can beneficially affect disorders induced by the consumption of an obesogenic diet.DesignThirty-two male Wistar rats were randomly assigned to four groups of eight animals each and fed with a basal or obesogenic (high in fat and low in fiber) diet that contained either strawberry seed oil or an edible rapeseed oil. A two-way analysis of variance was then applied to assess the effects of diet and oil and the interaction between them.ResultsAfter 8 weeks of feeding, the obesogenic diet increased the body weight and the liver mass and fat content, whereas decreased the cecal acetate and butyrate concentration. This diet also altered the plasma lipid profile and decreased the liver sterol regulatory element-binding protein 1c (SREBP-1c) content. However, the lowest liver SREBP-1c content was observed in rats fed an obesogenic diet containing strawberry seed oil. Moreover, dietary strawberry seed oil decreased the cecal short-chain fatty acid concentrations (acetate, propionate, and butyrate) regardless of the diet type, whereas the cecal β-glucuronidase activity was considerably increased only in rats fed an obesogenic diet containing strawberry seed oil. Dietary strawberry seed oil also lowered the liver fat content, the plasma triglyceride level and the atherogenic index of plasma.ConclusionsStrawberry seed oil has a potent lipid-lowering activity but can unfavorably affect microbial metabolism in the distal intestine. The observed effects are partly due to the synergistic action of the oil and the obesogenic diet.

Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study

“…In addition, treatment with POM normalized SREBP-1c hepatic mRNA expression, thus suggesting that the hepatoprotective effects of POM operate via normalization of lipid metabolism. Consistently, a previous study demonstrated that strawberry seed oil was able to decrease SREBP-1c hepatic content, which was associated with reduced plasma triglycerides and a decreased proportion of liver fat (28).…”

Ultraviolet light‐C increases antioxidant capacity of the strawberry (Fragaria x ananassa) in vitro and in high‐fat diet‐induced obese rats

“…Second, our results show that the NSE and UViSE did not have any significant effect on the food intake, consumption of energy and gain of body weight. In contrast, it was reported that raspberry seed oil decreases of liver fat content and atherogenic index in healthy rats and rats with low-grade systemic inflammation (Jurgoński, Fotschki, & Juśkiewicz, 2015), whereas in alloxan-induced diabetic rats the strawberry extract was effective to restore the body weight loss and hyperglycemia (Abdulazeez & Ponnusamy, 2016). Likely, these differences between our data and these reported by others are due others used (Pieszka, Tombarkiewicz, Roman, Migdał, & Niedziółka, 2013).…”

Raspberry Polyphenolic Extract Regulates Obesogenic Signals in Hepatocytes

“…Ellagitannins were confirmed by HPLC-ESI-MS using a Dionex UltiMate 3000 UHPLC and a Thermo Scientific Q Exactive series quadrupole ion trap mass spectrometer [ 20 ]. A Phenomenex Luna 5 μm C18 (250 × 4.6 mm) column was used with a binary gradient of 1% formic acid as mobile phase A and water/acetonitrile (1:4 v / v ) as mobile phase B at a flow rate of 1.0 mL/min.…”

“…Additionally, a nutritional study performed on rats with metabolic syndrome symptoms induced by a high-fat diet showed that ellagic acid attenuates diet-induced impairment of glucose tolerance and reduces NF-κB protein levels in the liver [ 17 ]. In addition, our previous nutritional experiments with dietary extracts from raspberries have indicated that these extracts are effective at decreasing total triglycerides and cholesterol in the blood and modulate hepatic lipid metabolism in rats fed with a high-fat diet [ 18 , 19 , 20 ]. The regulatory effects observed in the liver partially support the hypothesis that raspberry extracts can reduce liver disorders induced by a high-fat diet.…”