Dietary strategy for prevention and management of dyslipidemia: international guidelines

Abstract

Primary prevention of cardiovascular disease should begin with a detailed metabolic study of our patients who must follow a nutritional therapy. Recently, new guidelines ESC/EAS 2011 on the treatment of dyslipidemia have been drawn up, according to which it is possible to arrive at desirable values of cholesterol and triglycerides with a synergy between drug treatment and adequate diet therapy. At this time, Mediterranean diet has been undergoing a radical transformation: there is hyperalimentation of the Mediterranean diet in all its components. The effectiveness of the Mediterranean diet on the reduction of lipids has been demonstrated, and the problem is how to implement this diet in the general population and dyslipidemic patients. Certainly, awareness, education of their nutritional status, suitable food and portions can increase adherence to diet.

Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia

“…Phosphorylated ACLY plays a role in regulating inflammation and repairing DNA damage in macrophages, cancer cells and T cells, because it regulates the nuclear acetylation of substrates at the level of these cells. Finally, it has been observed that ACLY is highly expressed in some pathological conditions, such as in the fasting of obese patients with high insulin resistance [11]. This enzyme intervenes in lipid metabolism by catalyzing the following reaction: citrate + ATP + CoA → oxaloacetate + acetyl-CoA + ADP + Pi (Fig.…”